Recent News and Articles on the Keywords: smallpox + immunity + skin  Related to the article below (Last Update: 12/1/2008)

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Bush Nazis Are a Public Health Hazard
Arkansas Indymedia, Arkansas - Nov 4, 2008
The only viruses that have probably been proven to be viruses are the smallpox virus and the tobacco mosaic virus. As for SARS, that sounds like a Sad ...
Another Puppet Ruler USA 11/16
Indymedia Venezuela, Venezuela - Nov 20, 2008
The only viruses that have probably been proven to be viruses are the smallpox virus and the tobacco mosaic virus. As for SARS, that sounds like a Sad ...
Source: Google News


 

Recent News and Articles on the Keywords: smallpox + test + immunity  Related to the article below (Last Update: 8/7/2008)

Experts Examine Whether Adults Are Over-Vaccinated
KDKA, PA - Aug 1, 2008
The study could lead to a simple blood test to check your immunity. "Based on that information, we determine, yeah, it's time for your tetanus shot or, ...

MLive.com
Contact the Newspaper:
MLive.com, MI - Aug 3, 2008
Vaccines and efficacy The first disease people tried to prevent by intentionally inoculating themselves with infected matter was smallpox. ...
SLU Studies Experimental Smallpox Vaccine for Eczema Patients
Saint Louis University, MO - Jul 11, 2008
LOUIS -- Researchers at the Saint Louis University School of Medicine are preparing to test a new, experimental smallpox vaccine on people with atopic ...
High-tech Minn. health lab focused on new risks
KAALtv.com, MN - Jul 24, 2008
Bartkus said the operating theory now is that the pork tissue triggered the workers' immune systems. -Lab tests confirmed in 2005 that an Amish infant in ...
Technology with $3M Phase 2 SBIR Grant
Proteo Monitor, NY - Jul 17, 2008
?In that case, that really requires a test kit that accommodates that many analytes,? Liang said. ?There?sa need for a simple, affordable, ...
Source: Google News

Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox Vaccination 1 -
S Crotty, P Felgner, H Davies, J Glidewell, L … - The Journal of Immunology, 2003 - Am Assoc Immnol
... and serum Ab results after smallpox vaccinaiton that ... used in this paper: VIG, vaccinia
immune globulin; PRNT, plaque reduction neutralization test; PRNT 50 ...

Duration of antiviral immunity after smallpox vaccination -
E Hammarlund, MW Lewis, SG Hansen, LI Strelow, JA … - Nature Medicine, 2003 - webdrive.service.emory.edu
... Current views on smallpox immunity suggest that it is low or nonex- istent in
today?s population because of the lack of mass vaccination since the mid 1970s ...

Prediction of residual immunity to smallpox, by means of an intradermal skin test with inactivated … -
SH Kim, JW Bang, KH Park, WB Park, HB Kim, NJ Kim, … - J Infect Dis, 2006 - UChicago Press
... the intradermal skin test (the largest ?Area under ROC curve?) appears to be the
preferred test for prediction of residual immunity to smallpox, if we ...

Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against … -
LS Wyatt? - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences
... 2. Anti-comet test. ... Smallpox is believed to spread mainly by the upper respiratory
route, and we ... studies are needed to compare the duration of immunity to MVA ...

Induction of human T cell-mediated immune responses after primary and secondary smallpox vaccination … -
JS Kennedy, SE Frey, L Yan, AL Rothman, J Cruz, FK … - The Journal of Infectious Diseases, 2004 - UChicago Press
... Choe. (2006) Prediction of Residual Immunity to Smallpox, by Means of an
Intradermal Skin Test with Inactivated Vaccinia Virus. The ...

A Prospective Study of Serum Antibody and Protection Against Smallpox -
TM Mack, J Noble Jr, DB Thomas - The American Journal of Tropical Medicine and Hygiene, 1972 - ASTMH
... of neutralizing antibody and immunity to small pox is a ... indicators of susceptibility
to smallpox the neutralizing antibody test, properly performed ...

Safety and immunogenicity of new cell-cultured smallpox vaccine compared with calf-lymph derived … -
RN Greenberg, JS Kennedy, DJ Clanton, EA Plummer, … - The Lancet, 2005 - Elsevier
... immunogenicity of the new cell-cultured smallpox vaccine (CCSV ... doses of either CCSV
or test vaccine (2 ... by pock formation (take rate), humoral immune response by ...

Smallpox Vaccination: A Review, Part I. Background, Vaccination Technique, Normal Vaccination and … -
VA Fulginiti, A Papier, JM Lane, JM Neff, DA … - Clinical Infectious Diseases, 2003 - UChicago Press
... techniques have suggested that both antibody and cell-mediated immune function are
stimulated by smallpox vaccination, but no surrogate test for clinical ...

The Antibody Response to Smallpox Vaccination as Measured by a Tissue Culture Plaque Method -
E Cutchins, J Warren, WP Jones - The Journal of Immunology, 1960 - Am Assoc Immnol
... basic index of immunity to small- pox has been ... as methods for estimating smallpox
immunity, but neutralizing ... this reason, a neutralization test combining the ...

Smallpox Vaccination and Patients with Human Immunodeficiency Virus Infection or Acquired … -
JG Bartlett - Clinical Infectious Diseases, 2003 - UChicago Press
... in patients with compromised cell-mediated immunity, such as ... problems with the logistics
of HIV testing as a contingency for smallpox vaccination are the ...

Source: Google Scholar
 
 

Skin test predicts remaining immunity to smallpox

Skin testing with killed vaccinia virus, which is related to smallpox, is a simple and reliable way of predicting residual immunity to smallpox, a study shows.

"Residual immune response decades after smallpox vaccination is important for public health and vaccine development," the study team notes. The current findings suggest that skin testing with inactivated vaccinia virus is useful in assessing this response, they add.

Dr. Myoung-don Oh, from the Seoul National University Hospital in South Korea, and colleagues administered the skin test to 83 subjects, 63 of whom had a history of smallpox vaccination. Two days later, all of the subjects underwent smallpox vaccination.

The appearance of skin lesions after vaccination was used to determine immunity status.

 

Pustules 8 days after vaccination indicated a lack of residual immunity, whereas a rapidly evolving area of hardening around a central lesion indicated the presence of immunity, the researchers explain in The Journal of Infectious Diseases.

Thirty subjects showed a lack of residual immunity, 34 displayed residual immunity, and 19 had indeterminant results and were excluded from further analysis.

All told, the skin test had an 85 percent sensitivity and a 97 percent specificity in predicting residual immunity to smallpox.

By contrast, other measures of assessing residual immunity, such as the vaccinia-specific T cell response and the presence of neutralizing antibodies, were not as sensitive or specific as skin testing in predicting residual immunity.

SOURCE: Journal of Infectious Diseases August 1, 2006.

 
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