Poll: Support for Japan PM plunges China Daily, China - He has already had to apologize for joking about people with Alzheimer's disease, for saying the ideal country would be one that attracts "the richest ...
Drugs you can't have Stuff.co.nz, New Zealand - Nov 30, 2008 A class of drugs touted as potential treatments for Alzheimer's disease. There are three variants: donepezil (marketed as Aricept) rivastigmine (Exelon) and ...
Rude Robots, Stay Away From Homes PC World - Nov 19, 2008 Customizable robots can also detect early signs of dementia or Alzheimer's disease, for which they can provide continued support, Matarić said. ...
Politicians cool heated argument with water Ninemsn, Australia - Nov 28, 2008 Fast-food linked to Alzheimer's: studyEating fast food could contribute to the risk of developing Alzheimer's disease, according to a new Swedish study ...
Be aware of stages of Alzheimer's disease Desert Valley Times, UT - Nov 11, 2008 For example it may be pain, tiredness, or frustration. Because Alzheimer's patients feel reassured by routine, it is important to always have a peaceful, ...
Parents of a Down?s child must make painful choices Times Online, UK - Nov 29, 2008 ... intestinal malformation, leukaemia, kidney and thyroid disease, poor hearing and vision and early-onset Alzheimer?s (25% as opposed to the normal 6%), ...
Alzheimer's: the cruelest disease Boyertown Berk Montgomery Newspapers, United States - Nov 12, 2008 In many ways Alzheimer's is the cruelest disease. It is a disease of the brain that devastates what we think of as the very core of a person: their ability ...
From the Los Angeles Times Chicago Tribune, United States - Nov 17, 2008 In June, the Centers for Disease Control and Prevention reported that Alzheimer's disease is now the sixth leading cause of death in the United States: ...
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New Alzheimer's Drug for Advanced Disease
Much to the frustration of their caregivers, people with moderate to severe Alzheimer’s disease have had no treatment options. But that will change next January when a drug called memantine, marketed as Namenda, hits the US market. On October 17, the US Food and Drug Administration approved memantine for the treatment of these patients. Previously, medications approved for Alzheimer’s disease—the leading cause of dementia—were only available to patients in earlier stages of the disease.
Alzheimer’s disease is a progressive condition that causes memory loss as well as confusion and a decline in one’s ability to perform tasks of daily living. On average, people live with the disease for eight years.
"The latter portion of the disease is associated with the greatest burden on the part of the caregiver." explains Barry Reisberg, MD, the principle investigator of a randomized study of memantine and the clinical director of the Silberstein Institute of Aging and Dementia at New York University School of Medicine. "Now, for the first time, when a family member says ’If only you could slow the progression of the disease down,’ we’ll be able to say that there is something we can do, pharmacologically."
While previously approved Alzheimer’s drugs increase levels of a chemical called acetylcholine, memantine blocks a neurotransmitter involved in learning and memory called glutamate, which, when elevated, may contribute to cell disruption and death. Neither type of drug treats the underlying causes of the disease, however.
Still, researchers say the approval of memantine is encouraging. According to memantine researcher Myron Weiner, MD, of the University of Texas Southwestern Medical Center in Dallas , "It’s a little step forward in terms of slowing disease progression, and it gives people an extra measure of hope."
