Support Groups Martinsburg Journal, WV - The Man-to-Man prostate cancer support group meets from 6:30 to 8:30 pm the second Thursday of each month at City Hospital's Dorothy McCormack Center in ...
Doctors, researchers on quest for a cure News-Herald.com, OH - Nov 28, 2008 The science fiction-sounding cyberknife uses pinpoint accuracy to help those with prostate cancer. "With cyberknife, they can much more carefully grade the ...
MicroRNA "Safety Switch" Prevents Spread of Cancer Howard Hughes Medical Institute, MD - Nov 13, 2008 Without the RNA switch keeping it in check, a cancer-promoting enzyme is freed to trigger the spread of prostate cancer. Researchers suspect the RNA may ...
Crack the Fat Loss Code Diet Blog, California - Here are some things I disagree with/feel could be improved: Chant claims that men should not consume flaxseed oil due to risk of prostate cancer. ...
Lights of Love special for Thelma Warwick Courier, UK - Nov 27, 2008 Mrs Atkins, whose brothers Eric died of prostate cancer and Keith of a brain tumour within a few months in 2006, explained why it is important to raise ...
Hair raising - why the moustache is making a brief comeback Herald.ie, Ireland - Nov 6, 2008 Prostate cancer is the most common male cancer and Irish men have a one in 12 chance of developing it. And those numbers are growing, with the National ...
Brachytherapy Vs. Cryoablation In The Treatment Of Prostate Cancer Medical News Today (press release), UK - Cohen JK, Miller RJ, Ahmed S, Lotz MJ, Baust J Ten-year biochemical disease control for patients with prostate cancer treated with cryosurgery as primary ...
Delay in body growth linked to prostate cancer Reuters - Aug 5, 2008 NEW YORK (Reuters Health) - Boys who reach their adult body size in their early 20s may be more prone to prostate cancer later in life than their peers who ...
Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study. - JM Chan, MJ Stampfer, E Giovannucci, PH Gann, J Ma … - The Journal of Urology, 1998 - jurology.com ... Plasma Insulin-Like Growth Factor-I and ProstateCancer Risk: A Prospective Study. ...
Citing Articles TOP. Obesity and prostatecancer. Current Opinion in Urology. ...
Intake of Carotenoids and Retino in Relation to Risk of Prostate Cancer - E Giovannucci, A Ascherio, EB Rimm, MJ Stampfer, … - jnci, 1995 - jnci.oxfordjournals.org ... Intake of Carotenoids and Retino in Relation to Risk of ProstateCancer. ... No consistent
association was observed for dietary retinol and risk of prostatecancer. ...
The Influence of Finasteride on the Development of Prostate Cancer - IM Thompson, PJ Goodman, CM Tangen, MS Lucia, GJ … - New England Journal of Medicine, 2003 - content.nejm.org The Influence of Finasteride on the Development of ProstateCancer. Ian M. Thompson,
MD, Phyllis J. Goodman, MS, Catherine M. Tangen, Dr.PH, M. Scott Lucia, MD ...
Quality-of-life outcomes in men treated for localized prostate cancer - MS Litwin, RD Hays, A Fink, PA Ganz, B Leake, GE … - JAMA, 1995 - Am Med Assoc ... Quality-of-life outcomes in men treated for localized prostatecancer. ... ABSTRACT |
FULL TEXT. Natural History of Early, Localized ProstateCancer Johansson et al. ...
MONDAY, July 31 (HealthDay News) -- Prostate cancer cells can use three different signaling pathways to inactivate a protein that causes cell death and resist hormone treatment to stay alive, a Wake Forest University Baptist Medical Center study concludes.
By inactivating a protein called BAD, prostate cancer cells become resistant to treatment that lowers levels of male hormones, such as testosterone, that prostate cells normally need to survive.
The finding, published in the July 28 issue of the Journal of Biological Chemistry, may help lead to more effective drug treatments for prostate cancer.
"The normal response of prostate cells when male hormones are blocked is cell death. The cancer finds a way to resist the treatment, and we wanted to discover the mechanism," senior researcher Dr. George Kulik, assistant professor of cancer biology, said in a prepared statement.
In prostate cancer cells, BAD is shut down by three signaling pathways activated by vasoactive intestinal peptide, epidermal growth factor and phosphoinositide 3-kinase. It appears that each of these three molecules is separately capable of inactivating BAD, which means that prostate cancer cells have three redundant survival mechanisms, Kulik said.
"Our findings suggest that BAD is an important switch in the development and growth of prostate cancer," he said.
Kulik and his colleagues hope to conduct research in animals in order to test their findings.
More information
The U.S. National Cancer Institute has more about prostate cancer.
