Recent News and Articles on the Keywords: diabetes drugs + diabetes drug + diabetes  Related to the article below (Last Update: 8/7/2008)

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Cholesterol drugs 'could help' diabetics

Cholesterol-lowering drugs may soon be routinely prescribed to people with diabetes, it emerged today.

The Government promised to act upon the findings of a major study, which showed that more widespread use of statins would dramatically cut rates of heart disease in diabetics. Elevated heart and artery disease risk is a recognised complication of diabetes. Yet currently people with the condition are not generally given statins, a class of drug that effectively reduces cholesterol.

Guidelines for doctors do not recommend prescribing statins to diabetic patients unless they have high cholesterol levels.

But the new findings show they can benefit people with diabetes even when their cholesterol is normal.

Researchers running a major investigation called the UK Heart Protection Study looked at 6,000 people with diabetes, about 600 of whom had type 1 disease in which all insulin production stops.

They were randomly allocated a 40mg daily dose of statin or a dummy drug. As a comparison, 14,500 people with arterial disease who were not diabetic also took part in the trial. The findings, published in the Lancet medical journal today, showed that for both groups taking statins reduced the risk of cardiac death, non-fatal heart attacks, strokes or having to undergo major surgical procedures such as by-passes by 25 per cent. The risk reduction rose to 33 per cent for diabetic patients who did not already have arterial disease - about half the diabetes group.

Dr Rory Collins, from the Clinical Trial Service Unit in Oxford, who led the trial, said: "The present study provides direct evidence that cholesterol-lowering therapy is beneficial for people with diabetes even if they do not already have manifest coronary disease or high cholesterol concentrations.

"Statin therapy should now be considered routinely for all diabetic patients at sufficiently high risk of major vascular events, irrespective of their initial cholesterol concentrations."

Dr Sue Roberts, the Government's National Clinical Director for Diabetes, said the research was evidence that taking statins can make a "significant improvement to the health of people with diabetes".

She added: "I want to ensure that the lessons of this research are acted upon everywhere as quickly as possible. Cholesterol will also be measured routinely to monitor how well the message is getting across, and to check that improvement is happening everywhere for as many people as possible."

The charity Diabetes UK pointed out that diabetics were five times more likely to develop heart disease than people without the condition.

Simon O'Neill, head of care developments, said: "There has been a lot of recent research into the use of these cholesterol lowering drugs.

"The projects all indicate that statins can offer real benefits to many people with diabetes, helping them to avoid heart attack and stroke - both common complications of diabetes. We hope that all health care professionals will take this research into account when treating people with diabetes."