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Scientists have discovered a natural 'marker' in breast cancer victims which may predict the chances of the disease returning after treatment.
Larger amounts of the marker - a gene - were found in women whose cancer came back after four years than in those who did not suffer a recurrence.
The discovery adds to a growing body of research which experts claim will allow doctors to build genetic profiles of patients, enabling them to target cancer treatments more effectively.
Researchers at Thomas Jefferson University in Philadelphia investigated the progress over 14 years of 121 women diagnosed with breast cancer between 1973 and 1995 who then received surgery and radiation.
They found that 39 per cent of those whose disease returned within four years had higher levels of a damaged anticancer gene p53 and its protein, compared to only nine per cent of those whose cancer did not come back. Less than half of women with high p53 levels lived for ten years without disease, compared with 67 per cent of women without any genetic changes, says a report in the journal Cancer.
The discovery could have a major impact on the types of treatment offered to women who are at greater risk of their cancer coming back. 'The results provide the first evidence in humans that p53 gene changes are also associated with poor responses to radiation therapy treatments,' said Professor Bruce Turner, who led the research team.
'Women with a genetic change in this important gene may need to be treated with additional therapies to prevent the development of recurrent breast cancer and minimise the risk of the disease spreading.'
