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Cold virus could fight tumours
A common cold virus could be used to fight one of the deadliest forms of brain cancer, say scientists.
Laboratory tests suggest a genetically-engineered version of the bug could wipe out the tumours within days.
Experts are so encouraged by the findings that they may carry out the first trials on humans late next year.
Trials on mice have shown that the redesigned virus avoids healthy brain tissue but targets and kills the cells making up malignant glioma - the most common and deadly form of brain tumour.
There are 1,800 cases of the disease each year in the UK and they are extremely difficult to treat.
The tumours rarely respond to surgery, radiation or chemotherapy and most patients die within 12 months of diagnosis.
But the new version of the cold virus, which does not cause illness, could offer patients hope for the first time.
The findings, published today in the Journal of the National Cancer Institute, are considered so promising that America's National Cancer Institute is providing the funding to produce a version of the therapy which will be tested on human patients, possibly by late next year.
A team of researchers at the University of Texas claim the virus, known as Delta-24-RGD, can spread like a wave through a tumour, infecting and killing cancer cells.
Dr Juan Fueyo, who led the research, said: 'We believe this therapy has a lot of potential but one that needs much more study.
'We've never seen this kind of response before with any other treatment tested in either animals or humans.'
The Delta-24-RGD virus is designed to replicate only in cancer cells, not healthy tissue, so while it kills the cancer cell it continues to reproduce itself.
The so-called 'viral smart bomb' then keeps targeting tumour cells until no more are left, at which point the virus dies.
The team, working with scientists from the University of Alabama and the Institut Catala d'Oncologia in Spain, found that more than half the mice treated with the virus survived for longer than four months.
Untreated mice, however, lived for less than three weeks.
The mice who were given the viral therapy were 'clinically cured' of their brain tumours, the scientists said.
Only empty cavities and scar tissue were found in the brains where the tumours once were.
'Biological viral therapy like this may be just what we need to treat a complex disease like cancer,' said Dr Frederick Lang, a scientist involved in the study.
'Cancer can be devious in that it does everything possible to evade destruction. But viruses are equally tricky in their quest to invade cells and propagate.
In this experimental war between cancer and a viral therapy, the virus won. Of course, we hope to obtain similar results when patients are tested but we cannot predict such success based on animal studies,' he added.
The researchers say a small area of healthy brain tissue around the tumour could be affected by the battle between the virus and the cancer.
But they will not know if any damage could be caused to the brain until the first phase of human trials are launched
The researchers also do not know if the human immune system will act against the virus.
'We hope that an immune reaction will not inactivate the therapeutic virus,' said Dr Lang. 'We want to get to the tumour before the virus can be inactivated,' he said.