Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

Recent News and Articles on the Keywords: cancer + matriptase + enzyme  Related to the article below (Last Update: 12/1/2008)

 News results: Standard Version | Text Version | Image Version  
Browse Top Stories

Recent

Archives

Blogs

News Alerts News Alerts

RSS | Atom
About Feeds

Your search - cancer + matriptase + enzyme - did not match any documents.
Suggestions:
Make sure all words are spelled correctly.
Try different keywords.
Try more general keywords.
Try fewer keywords.
Try Google Blog Search.
Also, you can browse today's headlines on the Google News homepage.
Source: Google News

 

Recent News and Articles on the Keywords: matriptase + cancer + enzyme  Related to the article below (Last Update: 8/7/2008)

… and characterization of a novel matrix-degrading protease from hormone-dependent human breast cancer … -
YE Shi - Cancer Research, 1993 - AACR
... The expression of 80-kDa enzyme can be detected in hormone-dependent human breast
cancer cell lines ... the serine protease domain of matriptase plays a ...

… : A rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer -
S Netzel-Arnett, JD Hooper, R Szabo, EL Madison, … - Cancer and Metastasis Reviews, 2003 - Springer
... cancer [9,16?25 ... three new human TTSPs identified through database homol- ogy screening,
namely matriptase-3, andthe DESC-like enzymes, DESC2 andDESC3 [T ...

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness -
N Jessani, Y Liu, M Humphrey, BF Cravatt - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences
... Syndrome Displays Low Matriptase Proteolytic Activity and Is ... and SP Gygi Assessing
Enzyme Activities Using ... Current Implications for Cancer Detection, Prevention ...

Molecular Cloning of cDNA for Matriptase, a Matrix-degrading Serine Protease with Trypsin-like … -
CY Lin, J Anders, M Johnson, QA Sang, RB Dickson - Journal of Biological Chemistry, 1999 - ASBMB
... surfaces of breast cancer cells, we hypothesize that matriptase may be involved
in breast cancer invasion ... in this study, we have purified the enzyme and its ...

The novel serine protease tumor-associated differentially expressed gene-15(matriptase/MT-SP 1) is … -
AD Santin, S Cane', S Bellone, E Bignotti, M … - Cancer, 2003 - doi.wiley.com
... Insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem. ...
Cancer Res. 1993;53:1409?1415. 15. ... Matriptase and HAI-1 are ...

… Hepatocyte Growth Factor and Urokinase/Plasminogen Activator by Matriptase, an Epithelial Membrane … -
SL Lee, RB Dickson, CY Lin - Journal of Biological Chemistry, 2000 - ASBMB
... Matriptase is an epithelial-derived, integral membrane serine protease. The enzyme
was initially isolated from human breast cancer cells and has been ...

Catalytic Domain Structures of MT-SP1/Matriptase, a Matrix-degrading Transmembrane Serine Proteinase -
R Friedrich, P Fuentes-Prior, E Ong, G Coombs, M … - Journal of Biological Chemistry, 2002 - ASBMB
... MT-SP1 (matriptase/TADG-15/suppressor of tumorigenicity 14; EC ... that was expressed
by human breast cancer cells ... The enzyme was initially assigned as a gelatinase ...

Possible role of matriptase in the diagnosis of ovarian cancer -
MD Johnson, MD Oberst, CYLRB Dickson - erm, 2003 - Future Drugs
... that matriptase activity might be important in the progression of ovarian cancer
is an intriguing one, bearing in mind the known substrates of the enzyme and ...

[PDF] Cysteine cathepsins: multifunctional enzymes in cancer -
MM Mohamed, BF Sloane - Nat Rev Cancer, 2006 - nature.com
... tumorigenesis; for example, the neutrophil enzyme MMP8 has ... found to protect against
cancer 6 . The ... Matriptase, a transmembrane serine protease, has recently ...
-

Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with … -
JD Hooper, L Campagnolo, G Goodarzi, TN Truong, H … - Biochem J, 2003 - pubmedcentral.nih.gov
... as a pro-atrial natriuretic peptide-converting enzyme. ... C. Expression of the serine
protease matriptase and its ... 1 in epithelial ovarian cancer: correlation with ...

Source: Google Scholar
 
 

Cell surface enzyme matriptase can cause cancer

Researchers at the National Institute of Dental and Craniofacial Research ( NIDCR ) and colleagues found in animal studies that a single, scissor-like enzyme called matriptase, when left to its own devices, can cause cancer.

This finding, published in the journal Genes and Development, marks the first report of a protein-cleaving enzyme, or protease, on the cell surface that can efficiently trigger the formation of tumor cells.

The authors also noted that matriptase is the first known cell-surface protease that can act as an oncogene.
 
" What makes matriptase potentially such a good molecular target to treat cancer is its accessibility," said NIDCR scientist Thomas Bugge, the senior author on the paper. " We don't have to trick the tumor cell to internalize a drug, then hope it reaches its destination in an appropriate concentration and duration. In this case, the bull's eye is right on the cell surface."

Bugge said the exact function of matriptase in healthy human cells remains a bit of a mystery.
Previous studies showed that cells comprising the outer lining, or epithelium, of nearly all human organs express the protease. They also suggest that matriptase might play a role in activating other membrane-bound proteins on the cell surface that are involved in signaling basic cellular activities, such as growth and motility.

Since its discovery nearly 13 years ago, scientists also have suspected that matriptase might have a dark side. It is overly abundant in a variety of epithelial-derived tumors, including breast, prostate, ovarian, colon, and oral carcinomas.
Then, in 2002, scientists reported women with breast and ovarian cancer have poor prognoses if their tumors contain high levels of matriptase. In fact, just two months ago, researchers reported for the first time that increased expression of matriptase is associated with more serious forms of cervical cancer.

Still unanswered, however, was the larger question of whether the protease, when deregulated and overexpressed, might actually cause cancer.
To find the answer, Bugge and colleagues produced mice that expressed the human version of the matriptase gene in a stable, readily measurable manner. "After our initial round of experiments, we found that the skin of the mice was quite sensitive to fluctuations in the levels of matriptase," said Roman Szabo, a co-lead author on the study. " So much so, that all 10 of the mice that produced too much matriptase developed distinctive, splotchy skin lesions within a year."

According to Szabo, that's when things took an unexpected turn. He and his colleagues biopsied the lesions and, to their surprise, found that they were tumors that had already advanced in most cases to a type of cancer called squamous cell carcinoma, a strong indication that the excess matriptase was driving the process.

The scientists next wondered whether excess matriptase and sustained exposure to a chemical carcinogen might be a dangerous combination, a scenario with obvious real world implications. They applied various doses of the chemical DMBA, a well-characterized carcinogen present in tobacco products, to a small area of skin on each of 40 newborn matriptase overproducers. Within seven weeks, 95 percent of these mice developed tumors compared to roughly 2 percent of normal, healthy mice. The group also found that the higher the exposure to DMBA in the matriptase overproducers, the greater the chances were that the tumors would turn cancerous.

" What we found is deregulated matriptase sends a strong and versatile pro-growth signal that can travel along more than one route to the cell nucleus," said Karin List, the other lead author. " But the key point is, like a classic oncogene, matriptase initiates the erroneous growth signal. As further confirmation of this, when we turned off matriptase, not only the tumors but the precancerous lesions never appeared in the mice."

" What this work really shows is the current list of about 100 known oncogenes remains very much a work in progress," said Bugge. " It's also clear that matriptase and the approximately 200 other distinct cell-surface proteases will have a lot more to tell us about human health and disease in the coming years."

Source: National Institutes of Health, 2005
 
 
 
Google
Web www.iconocast.com
 
 
 

 

Continue News With: News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 © 2002-2006

Keywords::

Contact Iconocast

Home Page