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Recent News and Articles on the Keywords: protein + obesity + sh2  Related to the article below (Last Update: 12/1/2008)

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Recent News and Articles on the Keywords: obesity + 0.29 + 202  Related to the article below (Last Update: 8/7/2008)

Isis Reports Financial Results and Highlights for Second Quarter ...
Earthtimes (press release), UK - 39 minutes ago
7407943 entitled "Antisense modulation of Apolipoprotein B Expression" Metabolic Program -- Highlighted our robust diabetes and obesity portfolio with nine ...ISIS
Source: Google News

The Risk of Obesity and the Trp64Arg Polymorphism of the beta 3-Adrenergic Receptor: Effect … -
MS Corbal?n, A Marti, L Forga, MA Mart?nez- … - Logo, 2002 - content.karger.com
... 0.05?3.78 0.34?3.24 0.29?20.4 * p ! 0.01. risk of obesity and the Trp64Arg mutation
with adjust- ment for gender, age, and METs using multivariate logis ...

… Basis of Plasma Variation in Adiponectin, a Global Endophenotype for Obesity and the Metabolic … -
AG Comuzzie, T Funahashi, G Sonnenberg, LJ Martin, … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc
... and triglyceride levels ( P = 0.36 and -0.29, respectively ... on the pathogenesis of
atherosclerosis in visceral obesity. Intern Med 38:202?206[Medline]; Okamoto Y ...

RELATION OF OBESITY TO CLUSTERING OF CARDIOVASCULAR DISEASE RISK FACTORS IN CHILDREN AND YOUNG … -
CG SMOAK, GL BURKE, LS WEBBER, DW HARSHA, SR … - American Journal of Epidemiology, 1987 - Oxford Univ Press
... The early onset of obesity and its relation with cardiovascular ... 0.41*" 0.31*" 0.29*"
0.17* 0.50"* 0.32"* 0.02 -0.00 0.40*" 0.27 ... 195 211 194 95 66 236 202 125 92 ...

… with extent of ?overweight?and various weight-height relationships in the assessment of obesity -
J Womersley, J Durnin - British Journal of Nutrition, 2007 - Cambridge Univ Press
... 50-68 52 88 40 30-202 1.012 0.016 0.986-1.041 ... m3 at 37"), d, is the density of the
FFM (which varies with age, muscular development and obesity, see Womersley ...

Orlistat, Sibutramine, or Combination Therapy: Which Performs Better on Waist Circumference in … -
N Aydin, P Topsever, A Kaya, M Karasakal, C Duman, … - The Tohoku Journal of Experimental Medicine, 2004 - J-STAGE
... Med., 2004, 202 (3), 173-180 -- The aim of ... in obese patients receiving different
anti-obesity treatments ... in waist circumference (3.4 cm, R 2 =0.29) per unit ...

The Effect of the-308A Allele of the TNF-a Gene on Insulin Action Is Dependent on Obesity -
J Pihlajamaki, M Ylinen, P Karhapaa, I Vauhkonen, … - Obesity Research, 2003 - NAASO
... 1.34 0.29 1.33 0.29 1.33 0.29 Total triglycerides (mM) ... TNF- Polymorphism and Lipid
Storage, Pihlajam?ki et al. OBESITY RESEARCH Vol. ... 1998;18: 1199?202. ...

Factors associated with obesity in Kuwaiti children -
MAA Moussa, AA Shaltout, D Nkansa-Dwamena, M … - European Journal of Epidemiology, 1999 - Springer
... 4 188 (41.0) 202 (44.2) ... of the biochemical variables were more correlated with the
obesity index, BMI ... HDL (mmol/l) 1.38 ? 0.29 1.29 ? 0.35** 1.39 ? 0.30 1.26 ...

Trends in fatness and the origins of obesity Ad Hoc Committee to Review the Ten-State Nutrition … -
SM Garn, DC Clark - Pediatrics, 1976 - Am Acad Pediatrics
... Erling Johansen and Stanley M. Garn, Diane C. Clark, Charles U. Lowe, Gilbert Forbes,
Stanley Garn, George Trends in Fatness and the Origins of Obesity ...

Association of obesity with anxiety, depression and emotional well-being: a community survey -
AF Jorm, AE Korten, H Christensen, PA Jacomb, B … - Australian and New Zealand Journal of Public Health, 2003 - Blackwell Synergy
... Methods and Concepts Obesity and anxiety, depression and emotional
well-being Page 3. ... (-0.40 ? 1.31) (-0.09 ? 0.29) (0.04 ? 0.56) ...

A prospective study of obesity and cancer risk (Sweden) -
A Wolk, G Gridley, M Svensson, O Nyr?n, JK … - Cancer Causes and Control, 2001 - Springer
... NHL (200 + 202) 9 0.7 0.3?1.3 43 1.6 1.2?2.1 52 1.3 1.0?1.7 ... p-value for trend 0.29
Prostate ?59 9 6.03 1.5 0.7?2.8 ... Obesity and cancer 17 Page 6. ...

Source: Google Scholar
 
 

Variants of the protein SH2-B might underlie obesity

A weight control protein with a key role in the brain's ability to monitor body fat content may yield new approaches for treating obesity and type 2 diabetes.

The findings in mice further suggest that particular variants of the protein SH2-B might underlie obesity in humans, the researchers said.

SH2-B, which has multiple functions in cells throughout the body, keeps the brain sensitive to the fat hormone leptin, found researchers from the University of Michigan Medical School.
Produced by fat tissue, the leptin hormone sends signals to the brain about the body's fat content. That signal, in turn, elicits adjustments in appetite and energy expenditure to maintain normal body weight.

 
Mice lacking SH2-B overeat and become obese, the team found. The animals additionally develop a metabolic syndrome characterized by high blood concentrations of leptin, insulin, and lipids. They also develop fatty livers and high blood sugar, the group reports.

" Our findings reveal SH2-B as an important positive regulator of leptin sensitivity inside cells of the brain region known as the hypothalamus," said senior author of the study, Liangyou Rui. The hypothalamus is a key area in the central nervous system that integrates neuronal, hormonal, and nutrient-related signals to maintain body weight, he explained.

Leptin is a hormone produced by fat that normally decreases food intake and increases energy expenditure. In many species, including humans, the hormone acts to stabilize weight and glucose balance through activating its receptors in the hypothalamus.

Earlier work by Rui's group found that SH2-B binds to a second protein, JAK2, to promote leptin signaling in cultured cells. Further work then identified a physiological role for SH2-B in the regulation of blood glucose; mice deficient for the protein develop insulin resistance and type 2 diabetes, they found.

The current study shows that SH2-B also regulates energy balance and body weight by enhancing leptin sensitivity in animals, Rui said.

Mice lacking a functional copy of the SH2-B gene were smaller at birth than normal mice. After 5 weeks of age, however, the mice began gaining weight rapidly and were about twice as heavy as normal littermates after several months, with at least a 2.8-fold increase in body fat content.

The mice also exhibited a near doubling of blood lipid levels and their livers grew to more than twice their normal size owing to a massive accumulation of fat, Rui said.

Moreover, the animals developed severely elevated blood glucose, insulin, and leptin concentrations. Elevated leptin levels are a hallmark of leptin resistance, a primary risk factor for obesity, he added.

Further examination found that the animals lacking SH2-B ate nearly twice as much as normal. Surprisingly, Rui said, the animals burned more calories; however, the animals still have a net positive energy imbalance of more than 60% higher than normal animals at 18–19 weeks of age, owing to voracious feeding. The mice also exhibited defects in the leptin signaling pathway in brain cells of the hypothalamus, they report.

Earlier studies have found that mice lacking leptin show marked obesity that is restored following leptin treatment, Rui said. However, obese animals, with high blood concentrations of the hormone, often exhibit resistance to leptin's usual effects. As a result, leptin itself has proven to be insufficient for obesity therapy.

The new findings reveal SH2-B as a critical component in maintaining leptin sensitivity, Rui said. Therefore, SH2-B and signaling events regulated by SH2-B may serve as potential therapeutic targets for the treatment of obesity and type 2 diabetes.

Source: Cell Metabolism, 2005
 
 
 
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