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Recent News and Articles on the Keywords: hearing + iesca + antibodies  Related to the article below (Last Update: 12/1/2008)

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Recent News and Articles on the Keywords: hearing + ear + 0.23  Related to the article below (Last Update: 8/7/2008)

Going home hearing
Stillwater Courier, MN -
It is a procedure that starts behind the ear with electrodes embedded under the skin. A microphone and processor convert sound waves into electrical ...
SoundBytes Recommends Avoiding Permanent Hearing Damage by Using ...
PR Web (press release), WA -
Noise induced hearing loss is caused by damage to special cells, called outer hair cells, located deep in the inner ear. When these cells are stimulated by ...
MSU study finds that not all hearing aids are created equal
MSU Today, MI -
... very low-cost hearing aids - those under $100 - have the potential to damage your hearing because they send very loud sounds into the ear. ...
Dealing with a gradual loss of hearing
Irish Times, Ireland - Aug 4, 2008
There are several causes for hearing problems. Conductive hearing loss is when there is an obstacle blocking the passage of sound through to the inner ear. ...
Ear Worn Digital Device to Debut with the Bible
PR-USA.net (press release), Bulgaria -
The driving force behind the Ear Bible is that faith comes from hearing and hearing from God's Word. Inventor and company president Chris Lascelles says, ...
New Hearing Aid Blocks Ambient Noise
Stop Aging Now, DC -
The open fit allows ambient sounds into the ear, and eliminates that "talking in a tunnel" feeling you get with conventional hearing aids that block the ear ...
Dr. Gott: Secretions may not be earwax
Northwest Herald, IL -
Generally, this process pushes wax into the ear canal and against the drum, causing pain, fullness and hearing loss. Try using mineral oil, baby oil, ...
Principal sent notice for suspending kid
Times of India, India -
... of pain in her left ear, she was referred to an ENT at DDU Hospital who confirmed damage to her ear. An audibility test too confirmed loss of hearing. ...

Daily Mail
Could your ipod wreck your hearing?
Daily Mail, UK - Aug 4, 2008
Permanent damage to hearing can occur from continuous exposure to noise louder than 85 decibels. When sound enters the ear it makes the eardrum vibrate. ...
Soldier may face murder charge in Afghan death
The Associated Press - Aug 5, 2008
He is also accused of cutting off the man's ear, larceny and violating a lawful order. Officials would not provide any additional detail about the larceny ...
Soldier charged with killing Afghan civilian FayObserver.com
all 140 news articles »
Source: Google News

… Acoustic Laboratories'(NAL) New Procedure for Selecting the Gain and Frequency Response of a Hearing … -
D Byrne, H Dillon - Ear and Hearing, 1986 - ear-hearing.com
... 0.18 (0.27) 0.15 (0.61) 0.23" (0.63) 0.27 (0.38) 0.21 ... in gain prescription as most
hearing aid volume ... basic formula for prescribing required real-ear gain was ...

Components and Determinants of Hearing Aid Benefit. -
S Gatehouse - Ear and Hearing, 1994 - ear-hearing.com
... (Ear & Hearing 1994;15:30-49) ... 0196/0202/94/1501-0030$3.00/0 Ear & Hearing Copyright
0 1994 by Williams & Wilkins Printed in the USA 30 Page 2. ...

… Dominant Inheritance of Branchial Arch Anomalies, Hearing Loss, and Ear Pits, and Exclusion of the … -
CA Stratakis, JP Lin, OM Rennert - American Journal of Medical Genetics, 1998 - doi.wiley.com
... Hereditary deafness in family with ear-pits (fistula ... syndrome in children with profound
hearing loss ... 100% Penetrance D8S1807 - -1.47 -0.78 -0.49 -0.23 ...

Presbycusis and Noise-Induced Hearing Loss*. -
U Rosenhall, K Pedersen, A Svanborg - Ear and Hearing, 1990 - ear-hearing.com
... 8 0.16 NS 0.20* 0.20' 0.10 NS 0.20 NS 0.15 NS 0.10 NS 0.23** * p < 0.05. "'p < 0.07. ...
258 Rosenhall et al. Ear and Hearing, Vol.11, No. 4, 1990 Page 3. ...

Inner ear involvement in rheumatoid arthritis: a prospective clinical study -
I Kastanioudakis, A Skevas, V Danielidis, E … - The Journal of Laryngology and Otology, 2007 - Cambridge Univ Press
... Grouping variable plaquenil: 0.42, 0.60 and 0.15 for the right and 0.23, 0.22 and ...
Elwany, S., Garf, A., Kamel T. (1986) Hearing and middle ear function in ...

… Aging of the Middle Ear in 129S6/SvEvTac and CBA/CaJ Mice: Measurements of Umbo Velocity, Hearing … -
JJ Rosowski, KM Brinsko, BI Tempel, SG Kujawa - JARO-Journal of the Association for Research in …, 2003 - Springer
... later, demonstrate a significant age- related hearing loss in ... 3 Distribution of ages
within the middle-ear testing group ... 1.6 ? 0.23 12.4 ? 0.72 21.7 ? 2.88 ...

Sensorineural Hearing Loss From Quinolinic Acid: A Neurotoxin in Middle Ear Effusions. -
RF Yellon, E Rose, MA Kenna, WJ Doyle, M … - The Laryngoscope, 1994 - laryngoscope.com
... 1.3 (SEM) nmol/L and a range from 0.23 to 146.0 ... in MEEs and that QUIN in the middle
ear has the ... to cross the RWM and cause sensorineural hearing loss, possibly ...

Auditory neuropathy/auditory dys-synchrony in school children with hearing loss: frequency of … -
TPY Tang, B McPherson, KCP Yuen, LLN Wong, JSM Lee - International Journal of Pediatric Otorhinolaryngology, 2004 - Elsevier
... and familial risk factors for hearing loss was 0.23%. ... 1000 school children with
severe-to-profound hearing loss were ... remnant, emissions in at least one ear [16 ...

Hearing Results after Tympanoplasty in Elderly Patients with Middle Ear Cholesteatoma -
K Nomura, Y Iino, H Hashimoto, JI Suzuki, K Kodera - Acta Oto-Laryngologica, 2001 - ingentaconnect.com
... Age (years) 20?29 ?0.10 NS ?1.13 30?39 NS 40?49 ?0.49 NS 50?59 3.48 NS 0.23 NS
Gender (male ... Sensorineural hearing loss in chronic ear surgery. ...

Static magnetic field and the inner ear: A functional study of hearing and vestibular function in … -
F? Winther, K Rasmussen, O Tvete, U Halvorsen, B … - Scandinavian Audiology, 1999 - informaworld.com
... ABR latency, wave 5 (ms) 5.83 5.81 0.02 0.09 0.23 ... 9. Leach W. Irradiation of the
ear. J Laryngol 1965; 79:870?873. ... A new approach to hearing loss prevention. ...

Source: Google Scholar
 
 

Damage to the inner ear caused by antibodies to IESCA can destroy hearing

In thousands of people each year, the immune system attacks the inner ear, home to the tiny, delicate structures that allow us to hear.
Without warning, in days or weeks, patients lose the ability to hear in one or both ears.
Some might get part or all of their hearing back if they take steroid medicines, but many are left to cope with partial or total deafness without knowing what caused it. And no one knows why it happens.

 
Now, a research based at the University of Michigan's Kresge Hearing Research Institute may help more patients find out quickly if steroids could help them, or if they can be spared the drugs' harsh side effects. It may also expand the definition of the condition, known as autoimmune sensorineural hearing loss or AISNHL, and help more people get a firm diagnosis of what's causing their mysterious hearing loss.

In the Archives of Otolaryngology – Head and Neck Surgery, researchers reports results from a study of 63 people with rapidly progressing hearing loss in Michigan, Pennsylvania and Indiana, and 20 people with normal hearing. The patients were suspected of having an auto-immune cause for their hearing loss, and all received steroids, but they hadn't been formally diagnosed.

The researchers found that more than half of the hearing-loss patients had antibodies against a protein found in the inner ear, called IESCA for inner-ear supporting cell antigen. This is a sign their immune systems recognized it as foreign.

" In all, 28 of the 63 patients experienced improvement in their hearing after steroid treatment, and 35 did not. But the vast majority, 89 percent, of those who improved had a positive immunofluorescence test for an antibody to IESCA that we have studied at U-M for years," says senior author Thomas Carey, at the U-M Medical School. " The results strongly suggest that a direct test for antibodies could accurately predict which patients will regain hearing with steroid treatment." Such a test, he notes, is still several years away from being available to patients.

The new findings also may be important to people with systemic autoimmune disorders such as lupus or rheumatoid arthritis. Such people may be prone to losing all or part of their hearing due to an overzealous autoimmune reaction. All eight study participants who had systemic autoimmune diseases showed signs of antibodies against IESCA. Six of them regained hearing after steroid treatment.

U-M researchers have been studying IESCA for several years in animals and have found that it may be a main target of the immune system's deafening attack on the inner ear. IESCA is found in the supporting cells that help make up the organ of Corti, a tiny but crucial structure inside the cochlea, or inner ear.

Inside the organ of Corti are the ultra-sensitive hair cells, whose movement in response to vibrations creates the nerve signals that are fed to the brain and interpreted as sounds and speech. Damage to the organ of Corti and hair cells, whether due to immune system attack, loud noise, trauma or medications, can diminish or destroy hearing.

The U-M team has developed a monoclonal antibody, called KHRI-3, that attaches to IESCA in the inner ear, and can be detected in living animal systems and cell cultures. It has allowed them to study IESCA's role in hearing loss in animal models, and show that damage to the inner ear caused by antibodies to IESCA can destroy hearing.
The KHRI-3 antibody creates a staining pattern that resembles a line of tiny wine glasses when it binds to IESCA in the organs of Corti of guinea pigs.

In previous papers, Carey and his colleagues have shown that IESCA has about the same molecular weight as -- but is distinct from -- a protein that serves as the basis for a currently available commercial AISNHL test. That test, based on a protein-separation test known as Western blot, is known to give accurate results only some of the time. The U-M team reported in previous paper in the Journal of Neuroscience that IESCA is identical to a protein called CTL2, or choline transport-like protein 2.

In the new study, the researchers tested blood from the 63 patients and 20 normal controls with two tests: a Western blot test and an immunofluorescence ( IF ) test based on KHRI-3. They correlated the results of those two tests with patients' response to steroid treatment, based on standard criteria and the results of hearing tests performed before and after treatment. They also considered patients' other autoimmune diseases, the length and pace of hearing loss progression before treatment, and age and gender.

Thirty of the patients were female, and 33 male; their average age was 47, reflecting the young age at which AISNHL typically begins. Twenty-six had lost hearing in both ears, the rest in the left or right ear. They had no known cause for hearing loss, and most had lost their hearing gradually over weeks, though eight had lost it over hours or days. Many also had dizziness, ringing or a sensation of fullness in their ears. In all, half regained some or all of their hearing after steroid treatment.

Seventy-five percent of the patients had "wine glass" staining with IF testing, and 68 percent had positive Western blot results for the same size protein as is used in the commercial test.

The two different blood tests weren't always consistent - - results were the same in 47 patients ( both positive or both negative ) but different in 16. But the IF test appeared give a more specific response to steroid treatment: patients who had a positive IF test result were three times more likely to improve after steroid treatment than those with negative IF results.

The two tests combined were even more predictive: 54 percent of those who had positive results on both tests improved after steroid, compared with 10 percent of those who had two negative results.

Interestingly, Carey notes, nearly all of the patients who had sudden hearing loss over hours or days had antibodies, and nearly all improved with steroids.

Since this kind of rapid-onset hearing loss has historically been excluded from the formal definition of AISNHL, Carey suggests the definition may need re-examining in light of this strong evidence for an immune-system cause in these patients.

Source: University of Michigan Health System, 2005
 
 
 
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