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Recent News and Articles on the Keywords: fatal + mifepristone + infections  Related to the article below (Last Update: 12/1/2008)

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Recent News and Articles on the Keywords: mifepristone + fatal + 12,700  Related to the article below (Last Update: 8/7/2008)

Nurse who Gave Abortion Drug to Wrong Patient Will not Lose License
Lifesite, PA - Jul 21, 2008
The abortion drug is usually administered only to women who are 9 weeks pregnant or less, after she has been administered a dose of Mifepristone, which, ...
Do it yourself abortions offered on the internet: MMA highlights ...
Malta Independent Online, Malta - Jul 12, 2008
These medicines, called Mifeprisone, (also known as Mifepristone, RU486, RU or Mifeprex, the abortion pill or mifegyne) and Misoprostol (also known as ...
Source: Google News

Fatal Infections Associated with Mifepristone-Induced Abortion -
MF Greene - New England Journal of Medicine, 2005 - content.nejm.org
Perspective from The New England Journal of Medicine -- Fatal Infections
Associated with Mifepristone-Induced Abortion. ...

[PDF] Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion -
M Fischer, J Bhatnagar, J Guarner, S Reagan, JK … - N Engl J Med, 2005 - medicinaepersona.org
... as a cause of infection in the female genital tract and fatal tox- ic ... after abortions
that were medically induced with 200 mg of oral mifepristone and 800 ?g ...
-

A Fatal Case of Clostridium sordellii Septic Shock Syndrome Associated With Medical Abortion -
E Wiebe, E Guilbert, F Jacot, C Shannon, B … - acogjnl, 2004 - acogjnl.highwire.org
... This patient developed fatal septic shock secondary to infection with C sordellii
after medical abortion with mifepristone and misoprostol. ...

Septic shock after medical abortions with mifepristone (Mifeprex, RU 486) and misoprostol -
S Murray, E Wooltorton - Canadian Medical Association Journal, 2005 - Can Med Assoc
... diarrhea. Rare but fatal cases of ruptured ectopic pregnancy have occurred.
Mifepristone is metabolized in the liver by CYP3A4. ...

Analysis of Severe Adverse Events Related to the Use of Mifepristone as an Abortifacient -
MM Gary, DJ Harrison - The Annals of Pharmacotherapy, 2006 - Harvey Whitney Books
... To date, the FDA has not publicly described mifepristone's non-fatal sequelae
as discovered through adverse event reports (AERs). ...

Pathophysiology of Mifepristone-Induced Septic Shock Due to Clostridium sordellii -
RP Miech - The Annals of Pharmacotherapy, 2005 - Harvey Whitney Books
... Two different theoretical mechanisms could account for mifepristone causing the
in utero growth of C. sordellii with resultant fatal septic shock. ...

Mifepristone/misoprostol: Fatal septic shock syndrome (first report with misoprostol): case report
I Blog - Reactions, 2005 - ingentaconnect.com
... Mifepristone/misoprostol: Fatal septic shock syndrome (first report with misoprostol):
case report. Source: Reactions, Volume 1, Number 1035, 2005-01-22 , pp. ...

Fatal sepsis with mifepristone, but no need to abort the drug. News item
RL Pharmanewsfeed - Inpharma Weekly, 2005 - inpharma.adisonline.com
December 10, 2005, :1517 > Fatal sepsis with mifepristone,... ... Fatal sepsis with
mifepristone, but no need to abort the drug. [News item]. ...

Mifepristone/misoprostol: Fatal septic shock: case report
R Weekly - Reactions Weekly, 2006 - reactions.adisonline.com
February 18, 2006, :1089 > Mifepristone/misoprostol: Fatal... ... Mifepristone/
misoprostol: Fatal septic shock: case report. [Case report]. ...

Rare but Fatal Outcome
N Seppa - JSTOR
... Rare but Fatal outcome Four deaths may trace lr to abortion pill In the 5 years
since mifepristone, the so- = called abortion pill, was approved in the z ...

Source: Google Scholar
 
 

Mifepristone linked to rare cases of fatal bacterial infections

The abortion drug Mifepristone ( Mifeprex, RU-486 ) has been linked to rare cases of fatal bacterial infections, but until now the connection has not been clearly understood.

In " Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii," author and Ralph P. Miech, at the Brown University, proposes two models of how this devastating reaction may occur.

The article is published in The Annals of Pharmacotherapy.

During an abortion, Mifepristone works by blocking the effects of progesterone, shutting off nutrition to the placenta and fetus.
 
However, Miech points out, the antiprogesterone effects of Mifepristone also cause changes in the cervix that allow C. sordellii, a common vaginal bacteria, to enter the cervical canal.
C. sordellii thrives in this low-oxygen environment and derives nutrition from the decaying fetal tissue.

Meanwhile, other hormonal effects of Mifepristone, known as antiglucocorticoid actions, are taking place throughout the body.
Through two models proposed by Miech, these antiglucocorticoid effects may interfere with chemical regulators known as cytokines, offsetting the delicate balance between over- and under-activation of the immune system.
This disruption impairs the body's ability to fight off C. sordellii and may help spread the bacteria's toxic by-products, a combination that sometimes results in widespread septic shock.

At least 5 women in the US and Canada have died from septic shock after taking Mifepristone.
C. sordellii has been linked to 3 of those cases, while the bacteria remains unidentified in the others. C. sordellii infections are rare outside of Mifepristone use and have proven particularly dangerous because they often lack the usual warning signs, such as fever and tenderness on examination.

In 2004, the labeling of Mifepristone was amended to include a black box warning about bacterial infections, sepsis, and death that may occur after use.

Source: Annals of Pharmacotherapy, 2005
 
 
 
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