Health calendar News-Leader.com, MO - Participants must be at least 50 years old (45 with a family history), and not have had a PSA test in the last year. Registration deadline is today. ...
Hadassah focuses on inherited cancer risk St.Louis Jewishlight.com, MO - Nov 29, 2008 Ivanovich outlined the steps in determining if a family has a genetic cancer risk. The first step is to look at family history of cancer, and make a chart ...
Raised hopes for prostate cancer sufferers Times Online, UK - Meanwhile, patients who have had prostatic cancer, or have a family history of it, should have a tomato-rich diet. I recommend vitamin D, ...
Vagina monologues Express Buzz, India - You cannot get breast cancer if nobody in your family has it A family history of breast cancer (particularly in more than one close relative, ...
Cracking insight into Coomera's cricket history Gold Coast News, Australia - CRICKET GOLD Coast is chipping in to raise funds for the Prostate Cancer Research Foundation. Apart from asking all players, officials and spectators for a ...
Thanksgiving is National Family History Day NewsOK.com, OK - Nov 26, 2008 But do you know if either of them has suffered a stroke, lost a parent to cancer or takes insulin shots for diabetes? aDoctors say family gatherings are the ...
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Recent News and Articles on the Keywords: may + 0.29 + risk Related to the article below (Last Update: 8/7/2008)
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Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. - P Szulc, MC Chapuy, PJ Meunier, PD Delmas - Journal of Clinical Investigation, 1993 - pubmedcentral.nih.gov ... The risk of hip fracture was increased in women with ... values (from 2.22 +/- 0.35 to
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… Study of Carotenoids, Tocopherols, and Retinoid Concentrations and the Risk of Breast Cancer - R Sato, KJ Helzlsouer, AJ Alberg, SC Hoffman, EP … - Cancer Epidemiology Biomarkers & Prevention, 2002 - AACR ... The risk of developing breast cancer in the highest ... total carotene (OR = 0.55; 95%
CI 0.29?1.03; P ... The results suggest that carotenoids may protect against ...
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HMG-CoA Reductase Inhibitors and the Risk of Hip Fractures in Elderly Patients - PS Wang, DH Solomon, H Mogun, J Avorn - JAMA, 2000 - Am Med Assoc ... to adjust for the possibility that statins may be preferentially ... an even greater
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COFFEE USE PRIOR TO MYOCARDIAL INFARCTION RESTUDIED: HEAVIER INTAKE MAY INCREASE THE RISK - AL KLATSKY, GD FRIEDMAN, MA ARMSTRONG - American Journal of Epidemiology, 1990 - Oxford Univ Press ... This suggests that use of the two beverages may represent different life ... 0.03 0.29
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Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. - … Fleischmann, N Teal, J Dudley, W May, JD Bower, AK … - Kidney International, 1999 - pt.wkhealth.com ... The highest (27.60 ? 0.29, mean ? SE) and the lowest (24.54 ... decrease in BMI below
20, the relative risk was increased ... the high end of normal BMI may help to ...
Relation between Intake of Flavonoids and Risk for Coronary Heart Disease in Male Health … - EB Rimm, MB Katan, A Ascherio, MJ Stampfer, WC … - Annals of Internal Medicine, 1996 - annals.highwire.org ... 20 cases) remained significant (relative risk, 0.29 [CI, 0.09 ... cardiovascular disease
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Family history may be the most effective measure for cancer risk
One in five women diagnosed with breast or ovarian cancer who seek mammography have a family history of cancer that suggests they may harbor known cancer-causing gene mutations.
Researchers say the prevalence of such a family history is considerably higher than the rate among women with no personal history of cancer, and has significant implications for risk assessment, testing, and clinical management.
While less than 10 percent of breast or ovarian cancers have been linked to heritable gene mutations in BRCA1 and BRCA2, women with these mutations have up to an 80 percent lifetime risk of breast cancer and up to a 40 percent lifetime risk of ovarian cancer. Identification for prevention, early diagnosis and treatment are paramount to save lives.
A family history may be the most effective measure for cancer risk. Existing modeling studies report that less than 6 percent of women without a history of breast or ovarian cancer have family histories that may identify them as BRCA1/BRCA2 mutation carriers.
A small study of only 50 women with a history of breast or ovarian cancer reported that 22 percent had suggestive family histories.
For the new study, researchers led by Francisco J. Dominguez, and Kevin S. Hughes, of Massachusetts General Hospital reviewed family histories of 1764 women diagnosed with breast or ovarian cancer.
The data was then analyzed according to a risk assessment protocol, the Myriad Mutation Prevalence Tables, to identify women with a 10 percent or greater risk of having mutations.
Using this tool, they found that 20 percent of women with these cancers had a 10 percent or greater risk of harboring the cancer causing mutations.
Examination by cancer location showed that 100 percent of women with bilateral breast cancer, 35 percent of women with ovarian cancer, and 18.9 percent of women with unilateral breast cancer had a 10 percent or greater risk of oncogenic mutations.
More women of Ashkenazi ancestry reported high-risk family histories ( 47 percent ) compared to women of non-Ashkenazi ancestry ( 18 percent ).
