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Recent News and Articles on the Keywords: cancer + may + tgfbr1  Related to the article below (Last Update: 12/1/2008)

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Recent News and Articles on the Keywords: cancer + 262 + web  Related to the article below (Last Update: 8/7/2008)

Volunteer listings: August 7, 2008
Naples Daily News, FL -
Friends of the Library: 10 am-12:30 pm or 12:30 -3 pm Tuesdays and Wednesdays at Naples Branch Library, 650 Central Ave., Naples; 353-1765 or 262-8135. ...
Nonfiction Reviews
Publishers Weekly, NY - Aug 3, 2008
MIT, $24.95 (288p) ISBN 978-0-262-04246-8 Dauvergne (Paths to the Green World) takes a look at five industries to see what consequences they have on local ...
Red Sox, Cape League a perfect match
Norwich Bulletin, CT - Jul 23, 2008
?Kevin was a Commodore in 1999 and batted .262. He had never caught a game until [he came to] Falmouth. One catcher was hurt and another sick so he caught ...
Regional calendar
Wicked Local Roslindale, MA - Jul 10, 2008
The Greatest Bar is located at 262 Friend Street in Boston. For more information about this event, or to reserve a spot, visit BostonEventGuide.com. ...
Community Calendar
Livingston Daily, MI - Jul 9, 2008
Call (313) 262-2248 to register. Singing ? The Howell Area Parks and Recreation Authority plans group vocal lessons from 10 am to noon Saturday, ...
Parkway regional calendar
Wicked Local Roslindale, MA - Jul 16, 2008
The Greatest Bar is located at 262 Friend Street in Boston. For more information about this event, or to reserve a spot, visit BostonEventGuide.com. ...
Wine/Food Events - July
AZ Central.com, AZ - Jul 8, 2008
Arcosanti, Interstate 17, Exit 262, Cordes Junction. $40 for dinner and performance; $20 for performance only; $10 for students for performance only. ...
State ranked on gas-price vulnerability
Milwaukee Journal Sentinel, WI - Jul 22, 2008
Anyone with information may call the Racine Police Department's Investigative Division at (262) 635-7757 or Crime Stoppers at (262) 636-9330. ...
Local Band Directory
Northwest Herald, IL - Jul 11, 2008
Schedule: 9 pm July 11, Boondocks, 1200 W. Hawthorne Lane, West Chicago; 9 pm July 19, Gavers Cancer Benefit at Emricson Park, Woodstock; 9 pm July 26, ...
Source: Google News

BRAF mutation in thyroid cancer -
M Xing - Endocrine-Related Cancer, 2005 - Soc Endocrinology
Endocrine-Related Cancer 12 (2) 245-262 DOI: 10.1677/erc.1.0978
Copyright ? 2005 by the Society for Endocrinology. ...

[PDF] Tailoring messages and design in a web-based skin cancer prevention intervention
JM Bernhardt - International Electronic Journal of Health Education, 2001 - bvsde.paho.org
... 2000/virtualvillages/ story/essays/rogers/print.html Skin Cancer Foundation. ... 26,
2001 from the World Wide Web: http://www ... Journal of Family Practice, 39, 262-270 ...

[PDF] Terminology issues in user access to Web-based medical information -
AT McCray, RF Loane, AC Browne, AK Bangalore - Proc AMIA Symp, 1999 - amia.org
... Schwartz C. Web search engines. ... 384 index medicus 210 lupus 376 diabetes 208 brain
302 fibromyalgia 203 breast cancer 297 cancer 195 creatine 262 heart 188 ...

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice -
CA O?Brien, A Pollett, S Gallinger, JE Dick - Nature, 2007 - nature.com
... Full text access provided to Googlebot Access by Web Services. ... The frequency was
calculated to average one CC-IC in 262 CD133 + colon cancer cells (95 ...

Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To … -
C Sotiriou, P Wirapati, S Loi, A Harris, S Fox, J … - jnci, 2006 - jnci.oxfordjournals.org
... National Cancer Institute 2006 98(4):262-272; doi ... date of a diagnosed distant relapse
of breast cancer. ... dataset was downloaded from the Rosetta Web site (http ...

Outdated and Incomplete: A Review of Thyroid Cancer on the World Wide Web -
M Air, SA Roman, H Yeo, C Maser, T Trapasso, B … - Thyroid, 2007 - liebertonline.com
... 262 ... 66%) included that overall prognosis is good for well-differentiated thyroid
cancer. Fifty-four percent of web- sites failed to address the importance of ...

Online Information about Cancer Clinical Trials: Evaluating the Web Sites of Comprehensive Cancer … -
V Monaco, S Krills - AMIA Annu Symp Proc, 2003 - pubmedcentral.nih.gov
... the possibilities that enhanced Web sites may ... awareness slow recruitment for cancer
clinical trials ... Report=59&Section=ReportLevel1&Field=Level1ID&ID=262 (1 Mar ...

Evaluating the WEB Training Program for Cancer Screening in Native American Women*. -
WO Petersen, MA Trapp, MA Fanale, JS Kaur - Holistic Nursing Practice, 2003 - hnpjournal.com
... funded national program. In 1993, 262 Page 2. WEB Training Program for Cancer
Screening in Native American Women 263 Table 1. Values ...

… and Bioinformatics Approaches for Identification of Serum Biomarkers to Detect Breast Cancer -
J Li, Z Zhang, J Rosenzweig, YY Wang, DW Chan - Clinical Chemistry, 2002 - Am Assoc Clin Chem
... Proteomics and Bioinformatics Approaches for Identification of Serum Biomarkers
to Detect Breast Cancer. ... Home page, Cancer Epidemiol. Biomarkers Prev. ...

A genetic linkage map of the mouse: current applications and future prospects -
NG Copeland, NA Jenkins, DJ Gilbert, JT Eppig, LJ … - Science, 1993 - sciencemag.org
... that does not support current Web standards ... Science, Vol 262, Issue 5130, 57-66
Copyright ... ABL-Basic Research Program, National Cancer Institute-Frederick Cancer ...

Source: Google Scholar
 
 

TGFBR1*6A may represent a potential therapeutic target in cancer

A relatively common cancer susceptibility gene appears to be frequently acquired in metastatic lesions from colorectal cancer, and give cancer cells a growth advantage.

Transforming growth factor beta ( TGF-beta ) is a potent naturally occurring inhibitor of cell growth.
It exerts its action by binding to type I ( TGFBR1 ) and type II ( TGFBR2 ) receptors located on the cell membrane.
Increased cell growth due to decreased TGF-beta growth inhibition may contribute to cancer development. TGFBR1*6A is a common polymorphism of TGFBR1.

 
Previous studies have shown that TGFBR1*6A is one of the first candidate tumor susceptibility alleles that is found in a large proportion of the general population 13.7 percen) and significantly increases cancer risk by approximately 24 percent.
How TGFBR1*6A contributes to cancer development is largely unknown.

Boris Pasche, of Northwestern University Feinberg School of Medicine, Chicago, and colleagues conducted a study that included 531 patients with a diagnosis of head and neck cancer, colorectal cancer, or breast cancer recruited from 3 centers in the United States and from 1 center in Spain from June 1, 1994, through June 30, 2004. Multiple genetic testing of the cancer cells was conducted.

The researchers found that TGFBR1 mutated into TGFBR1*6A, i.e. was somatically acquired, in 13 of 44 ( 29.5 percent ) colorectal cancer metastases, in 4 of 157 ( 2.5 percent ) of colorectal tumors, in 4 of 226 ( 1.8 percent ) head and neck primary tumors, and in none of the 104 patients with breast cancer.

While TGF-beta inhibits the growth of normal cells, cancer cells secrete larger amounts of TGF-beta than their normal counterparts.
The researchers showed that, in the presence of TGF-beta, the growth of cancer cells that carry the TGFBR1*6A gene is 55 percent greater than cancer cells that do not carry this gene, indicating that TGFBR1*6A give cancer cells a selective advantage.
This, together with the findings that TGFBR1*6A is acquired by tumors, may explain why half of all liver metastases from colorectal cancer carried the TGFBR1*6A gene while it is only found in 14 percent of the general population.

"… individuals who carry the *6A allele, either in the germline or somatically acquired by the tumor, may have a greater likelihood of developing metastases than individuals who do not carry this allele. *6A may therefore serve as a useful biomarker in cancer. " The authors add that TGFBR1*6A may bestow cancer cells with a growth advantage in the presence of TGF-beta.

" Since 13.7 percent of the general population and 17.1 percent of patients with a diagnosis of cancer carry at least 1 copy of the *6A allele, our findings may have substantial public health importance. The high frequency of *6A carriers in the general population and the moderately increased risk of breast, colon, and ovarian cancer that it confers implies that the dominant effects of *6A have an incomplete penetrance. Additional studies are needed to determine which environmental and genetic factors may modify the penetrance of *6A in these tumor types," the researchers write.

Source: American Medical Association, 2005
 
 
 
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