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Recent News and Articles on the Keywords: drosophila + genetic + growth  Related to the article below (Last Update: 12/1/2008)

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Recent News and Articles on the Keywords: genetics + melanogaster + 0.07  Related to the article below (Last Update: 8/7/2008)

AT THE CONVERGENCE OF EVOLUTION AND GENETICS
ScienceBlogs - Jul 21, 2008
Long's group previously described an RNA gene that is unique to D. melanogaster, and not found in any of its sibling species (doi:10.1073/pnas.072066399). ...
Basics: Sonic Hedgehog
ScienceBlogs - Aug 1, 2008
In Drosophila melanogaster, SMO becomes hyperphosphorylated in response to HH signalling and accumulates in the plasma membrane, whereas in vertebrate cells ...
Full Text
Science Magazine (subscription) - Jul 17, 2008
So by the mid-1990s, when new molecular and genetic techniques pioneered in fruit flies and worms were illuminating everything from memory formation to ...
Drosophila RNAi screen identifies host genes important for ...
Nature.com (subscription), UK - Jul 9, 2008
Because of its powerful genetics and conservation with vertebrates, Drosophila has been used to make numerous critical contributions to mammalian cell ...
Full Text
Science Magazine (subscription) - Jul 24, 2008
XhoI has a single recognition site in the cytochrome c oxidase subunit I locus (mt:CoI) in the Drosophila melanogaster mitochondrial genome (fig. S2). ...
Krebsgen funktioniert anders als gedacht
Informationsdienst Wissenschaft (Pressemitteilung), Germany - Aug 6, 2008
Wie die Forscher in der renommierten Wissenschaftszeitschrift "Nature Genetics" berichten, kann Myc das Zellwachstum alleine anregen. ...
Wegweiser f?r das Zellwachstum
Informationsdienst Wissenschaft (Pressemitteilung), Germany - Jul 10, 2008
Die Fachzeitschrift Nature Genetics berichtet dar?ber in ihrer aktuellen Ausgabe. Zellen, die sich w?hrend der Embryonalentwicklung teilen und vermehren, ...
Source: Google News

Reduced Genetic Load Revealed by Slow Inbreeding in Drosophila melanogaster -
BDH Latter, JC Mulley, D Reid, L Pascoe - Genetics, 1995 - Genetics Soc America
... 0.07%, respectively, ... inbreed- ing, abdominal bristle number in Drosophila melanogaster
showing no ... of Cytogenetics and Molecular Genetics, Women?s and Children ...

Quantitative Trait Loci for Life Span in Drosophila melanogaster Interactions With Genetic … -
J Leips, TFC Mackay - Genetics, 2000 - Genetics Soc America
... interaction (F 1127 = 3.37, P = 0.07), with the ... invoke a stress response, and genetic
differentiation among ... adult life span in D. melanogaster ( KHAZAELI et al ...

… genetic study of the anesthetic response: mutants of Drosophila melanogaster altered in sensitivity … -
KS Krishnan, HA Nash - Proceedings of the National Academy of Sciences of the …, 1990 - JSTOR
... 13A1 0.43 + 0.15 0.10 + 0.13 0.11 + 0.07 RK2 12D2 ... An organism with much more tractable
genetics, the roundworm ... those that we have obtained in D. melanogaster. ...

Genetic variation at the alcohol dehydrogenase locus in Drosophila melanogaster in relation to …
JB Gibson, TW May, AV Wilks - Oecologia, 1981 - Springer
... However, in contrast to the extensive genetic and bio ... 0.79 (0.34) 0.17 1.33 3.52
(3.64) 0.07 10.78 2.54 ... wine seepages in which D. melanogaster were breeding ...

Rates and Patterns of scnDNA and mtDNA Divergence Within the Drosophila melanogaster Subgroup -
A Caccone, GD Amato, JR Powell - Genetics, 1988 - Genetics Soc America
... Genetics 118: 671-683 (April, 1988). ... Tracer Drivef D. melanogaster MEL-A MEL-B
MEL-C Oregon-R 0.1 1 f 0.06 0.04 ? ... 0.09 0.10 0.07 0.08 0.17 0.09 0.08 0.1 1 ...

Inbreeding increases genetic variance for viability in Drosophila melanogaster -
C L?pez-Fanjul, A Villaverde - Evolution, 1989 - JSTOR
... 11.8 Realized heritability: 0.40* 0.10 SE: 0.15 0.07 * P < 0.05 ... architecture of body
weight and egg hatchability in Drosophila melanogaster. Genetics 56:23-37. ...

Selection for Increased Desiccation Resistance in Drosophila melanogaster: Additive Genetic Control … -
AA Hoffmann, PA Parsons - Genetics, 1989 - Genetics Soc America
... In an initial report on the genetics of desiccation resistance in D. melanogaster
(HOFFMANN and PARSONS 1989), we described the response to artificial ...

… to Captivity and Inbreeding Depression in Small Laboratory Populations of Drosophila melanogaster -
BDH Latter, JC Mulley - Genetics, 1995 - Genetics Soc America
... in reproductive fitness in populations of D. melanogaster with mean ... Genetic Adaptation
and Inbreeding 257 ... with estimated inbreeding coefficients of -0.07-0.08. ...

… laboratory evolution of a genetic life-history trade-off in Drosophila melanogaster. 1. The role of … -
AM Leroi, AK Chippindale, MR Rose - Evolution, 1994 - JSTOR
... 20.85 17.89 Mean 0.33 1.02 1.56 2.32 2.21 8.39 15.81 15.51 SE 0.07 0.30 0.48 ... Quanti-
tative genetics of postponed aging in Drosophila melanogaster. ...

Genetic variability of quantitative traits in Drosophila melanogaster (fruit fly) natural … -
P GIBERT, B MORETEAU, JC MORETEAU, JR DAVID - nature.com
... variability in natural D. melanogaster populations from ... to reflect rearing conditions
than genetic differences ... for the mother-daughter regression (0.09?0.07). ...

Source: Google Scholar
 
 

A genetic mechanism that controls cellular growth in fruit fly Drosophila melanogaster discovered

Researchers at Emory University School of Medicine and their colleagues have discovered a genetic mechanism that controls cellular growth in the fruit fly Drosophila melanogaster, and believe it likely that a similar system may be at work in normal and cancerous human cells.

The findings appear in the journal Developmental Cell. Ken Moberg, at Emory University School of Medicine, is the lead of the paper.
 
The Emory and Berkeley researchers have uncovered important details about how mutational inactivation of the Drosophila version of Tumor Susceptibility Gene 101 ( Tsg 101 ) causes cells to overgrow, leading to organ hypertrophy and tumor-like growths.

Researchers first identified the human Tsg101 gene in the mid-1990s based on its ability to control the growth of cells in a culture dish, but little has been learned since then about how it does this.

" The work that was done ten years ago strongly implicated Tsg101 as a growth regulatory gene, but how it works has remained largely obscure," Moberg says.

In the interim, the Tsg101 gene has become better known for its role in "endosomal sorting," the process by which proteins are shuttled to and from the cell surface, but researchers had little luck connecting this property to the gene's potential role in human cancer. " People didn't really understand how the two would fit together," Moberg says.

Moberg's findings show that there is in fact a direct link between the "sorting" and growth regulatory roles of Tsg101.
Moberg and his team determined that defective sorting of the Notch receptor, a protein that sends signals throughout the cell, is key to the biology of Tsg101 mutant cells.

Endosomal sorting is an important way in which cells control Notch activity, and when Tsg101 mutant cells are unable to correctly sort Notch protein, it becomes hyperactivated, and causes excess tissue growth.

In addition, Moberg discovered that the mechanism through which Tsg101 controls cell growth is non-cell-autonomous, meaning that mutated cells cause surrounding normal cells to overgrow, resulting in tumor-like growths made up of a heterogeneous mix of cells, some normal, some mutated.

Before now, most mutations that cause cancer have been found to act cell-autonomously, that is the mutant cells themselves overgrow and form a genetically homogeneous tumor. For that reason, Moberg comments, " this is a very surprising and somewhat novel mechanism for a growth regulatory gene." He adds " these new findings suggest the possibility that, in fact, some as yet unidentified subset of human cancers might actually be composed of a mixture of normal cells and cells with mutations in genes like Tsg101."

While the research so far has been limited to Drosophila, Moberg expects his research to prompt a renewed focus on the role of the Tsg101 mutations in human cancers. " I'm hoping this will eventually translate into a better understanding of the role of the human version of the gene in disease," he says.

In addition, drugs already available that target Notch may find new uses if human Tsg101 is found to control growth in a similar way to fruit fly Tsg101. As Moberg says, " It may turn out that some of these drugs may actually be clinically useful in treating a hypothetical class of human cancers that harbor mutations in Tsg101."

Source: Emory University Health Sciences Center, 2005
 
 
 
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