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Recent News and Articles on the Keywords: ibuprofen + painkiller + 0.18 Related to the article below (Last Update: 8/7/2008)
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Safe` ibuprofen not so safe, causes bleeding
Ibuprofen is widely considered a safe painkiller, but a recent study says it can lead to gastrointestinal bleeding.
People who take high doses of ibuprofen on a regular basis are three times more likely to experience such bleeding than those who do not take painkillers, said the study published this week in the American Gastroenterological Association (AGA) journal Clinical Gastroenterology and Hepatology.
The research showed that significant bleeding could be observed as early as three days after starting an ibuprofen regimen in otherwise healthy people - giving credence to the belief that high doses of non-steroidal anti-inflammatory drugs (NSAIDs), no matter the safety profile, are likely to cause bleeding that can be harmful to the digestive system.
"Unfortunately, people dealing with chronic pain, such as arthritis, often increase the recommended dose of their painkillers and they should be aware that the effects on the gastrointestinal tract can be serious," Richard H. Hunt, senior study author, was quoted as saying by the EurekAlert website.
"Of all the NSAIDs available over the counter, ibuprofen was thought to have the least harmful effects on the gastrointestinal tract. However, our study shows that healthy, young people and older people are at great risk of internal bleeding and should speak with their doctor to determine the risks of taking large amounts of ibuprofen."
The research team from McMaster University Health Science Centre in Ontario, Canada, conducted a post-hoc analysis of two separate randomised studies that included 68 healthy volunteers who were given either four weeks of an ibuprofen regimen (800 mg, three times daily for 28 days) or a placebo - a dosage amount twice that of the recommended 1200 mg a day.
Of the healthy subjects included in the study, those taking ibuprofen for 28 days experienced blood loss that was 3.64-fold greater than the placebo group.
According to study authors and previous studies, though the ibuprofen dose was higher than the recommended over-the-counter amount, blood loss, anaemia and other adverse events could be observed at any dose of ibuprofen.
The study authors were hopeful that the findings would bring attention to the amount of painkillers potentially being used by patients at home and the fact that ibuprofen is often combined with other painkillers - potentially causing a greater amount of bleeding from the gastrointestinal tract.
"The potential for serious gastrointestinal complications should always be considered when ibuprofen is recommended for at-home use," said Hunt.
"Elderly people and those with debilitating conditions such as arthritis should be especially cautious about the medications they are taking together and the adverse effects of those interactions. Serious bleeding can always occur even with over-the-counter drugs that are considered safe."
