Rehab facilities finding many uses for Wii Fit Press of Atlantic City, NJ - This is quite a task for cerebral palsy patients, as they often have to find different ways of trying to walk and having control of their bodies over long ...
Self-control key to avoiding weight gain Danville Commercial News, IL - Nov 28, 2008 Carol Schriver, regional clinical nutrition manager for Provena United Samaritans Medical Center, said controlling one?s waistline boils down to watching ...
Scientists Take Swing at Golf Ball?s Dimples New York Times, United States - Nov 29, 2008 It must fall, under its own weight, through a 1.680 ring gauge in fewer than 25 of 100 randomly selected positions at a room temperature from 71.6 to 75.2 ...
Revolutionary New Diet Aid for Weight Loss PR Web (press release), WA - Losing weight is not always about joining the best gym or following the newest diet plan. It's about control and making lifestyle changes for long-term ...
Bynassing surgery might be possible Boston Globe, United States - Over the next several weeks, those rats lost 20 percent more weight and consumed 30 percent fewer calories than the control rats. Further, the treated rats ...
Web Designer Seattle Times, United States - Streamate is looking to hire an experienced web designer to work in our downtown Seattle office. Streamate.com is popular adult chat & live video service. ...
Web sites poke fun at McCain, Obama Detroit Free Press, United States - BY TODD SPANGLER ? FREE PRESS WASHINGTON STAFF ? August 6, 2008 Today, it came in the form of a Web site -- courtesy of the Democratic National Committee ...
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[BOOK] The Souls of Black Folk - WEB Du Bois - 2003 - books.google.com Introduction and Notes by Farah [asinine Griffin ... Ul. I \\ Ii; ?M il l
wlVSm, lm I rw i- II t ? \\ . IN \\ 'Ik I ... Sill '. fc/IIT* K.II, , ?\\
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Measuring the Independence of Central Banks and Its Effect on Policy Outcomes - A Cukierman, SB Web, B Neyapti - The World Bank Economic Review, 1992 - World Bank Making the central bank an agency with the mandate and reputation for
maintaining price stability is a means by which a government can choose the
strength of its commit- ment to price stability. This article develops four ...
Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide … - W Focuses, NPG Contact - The EMBO Journal, 1997 - nature.com The crystal structure of the phosphorylated, activated form of the insulin
receptor tyrosine kinase in complex with a peptide substrate and an ATP analog
has been determined at 1.9 ? resolution. The activation loop (A-loop) of ...
[BOOK] The Autobiography of WEB DuBois: A Soliloquy on Viewing My Life from the Last Decade of Its First … WEB Du Bois - 1968 - books.google.com The Soliloquy is a unique, personal commentary upon a century in which Dr. Du
Bois played a most conse- quential role. Perhaps more than any- one else, his
deeply informed, impas- sioned writings and ceaseless activity brought to ...
Clonal expansion of p 53 mutant cells is associated with brain tumour progression - D Sidransky, T Mikkelsen, K Schwechheimer, ML … - Nature, 1992 - nature.com * The Department of Oncology, The Johns Hopkins University School of Medicine,
Baltimore, Maryland 21231, USA ? Ludwig Institute for Cancer Research,
Montreal, Province of Quebec, H3A 1A1, Canada ? Abteilung Neuropatologi ...
All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral - W Focuses, NPG Contact - The EMBO Journal, 1998 - nature.com Ras, Rap1 and Ral are related small GTPases. While the function of Ras in signal
transduction is well established, it has been recognized only recently that Rap1
and Ral also are activated rapidly in response to a large variety of ...
[PDF]The World-Wide Web - T Berners-Lee, R Cailliau, A Luotonen, HF Nielsen, … - Communications of the ACM, 1994 - computertextbook.com The World Wide Web is the total collection of Web pages that are stored on Web
servers located all over the world. Schools, companies, and other organizations
often have their own Web server. Web serv- ers are also provided by Web ... -
[DOC]ISSUES OF INTEREST - WEB STATS - swenvo.org.uk The South West Observatory is currently co-ordinating a State of the region
report for the Regional Assembly, in which the environment and climate change
will both feature as chapters. The environment chapter will be broken down ...
[CITATION] The Souls ofBlack Folk WEB Du Bois - Three Negro Classics, 1903
Identification of the gene altered in Berardinelli- Seip congenital lipodystrophy on chromosome … - A Web Table, B Web Table, C Web Table - Nature Genetics, 2001 - nature.com ...Web Table A (pdf 10K). Web Table B (pdf 11K). Web Table C (pdf 13K). Top. SUPPLEMENTARY
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Appetite Suppressing Hormone Discovered
There’s a new entry in the field of weight-controlling hormones, a finding of potential importance to the millions of Americans trying to lose weight without giving up their zest for eating.
The Stanford University researchers who discovered it have named it obestatin. It acts to suppress appetite, and its commercial possibilities are noted by sponsorship of the research by the pharmaceutical company Johnson & Johnson.
Obestatin joins leptin, melanocortin and ghrelin, hormones identified in the last few years as acting on appetite and weight. So far, work with those molecules has not produced the hoped-for cure for obesity.
The obestatin discovery comes with a couple of twists. One is that it’s produced by the same gene that produces ghrelin, which acts to suppress appetite. Another is that major credit for the discovery is given to Charles Darwin’s theory of evolution.
The principles of evolution led to identification of obestatin, said Aaron Hsueh, a professor of obstetrics and gynecology at Stanford, in whose laboratory the work was done. He also credited the information gathered by the Human Genome Project, which produced a complete human gene map.
Hsueh and his colleges used human genome data to study small-peptide hormones, which are active throughout the body. Specifically, they looked at the receptors for those hormones -- the cellular molecules to which the hormones are attached when they go into action. There are about 300 such receptors, of which 100 had no known hormone partner.
The search for missing hormones was narrowed by focusing on receptors that have been around for hundreds of millions of years and are found in many species. One of those receptors is for ghrelin. Further studies showed that ghrelin actually had another protein tacked on to it -- obestatin.
When the researchers injected obestatin into rats, "to our surprise, we found that treatment with it suppresses food intake," Hsueh said. And so, he added, "it could have potential as an appetite-suppressing drug, by injection. Or it might be possible to deliver by nasal spray. It also allows us to screen for new drugs that might suppress appetite."
The study findings appear in the Nov. 11 issue of the journal Science.
But Matthias Tschop, associate professor of psychiatry at the University of Cincinnati, and co-author of an editorial in the journal on obestatin, is sounding a note of caution.
"The effect of obestatin on body weight seems to be relatively limited," Tschop said. "Also, it might cause some sort of illness or nausea that causes a decrease in food intake."
The effect of obsestatin was discovered in research with rodents, Tschop noted. "The most obvious question is, does obestatin work in obese animals?" he said.
And the business of weight regulation is complicated, Tschop added. "There are many other players involved," he said. "And obestatin may have many other functions. For example, it could regulate physical activity."
But with all those caveats taken into consideration, the discovery of obestatin is "a step in the right direction," Tschop said.
