Chemo-immunotherapy Not Better Than Chemotherapy Alone for ... Cancer Consultants, ID - Nov 17, 2008 Immunotherapy agents include interferon-alfa (INF-alfa) and interleukin-2 (IL-2). However, most therapy is palliative, thus tolerability of treatment is a ...
ZymoGenetics Inc Q3 2008 Earnings Call Transcript Seeking Alpha, NY - Nov 19, 2008 We will also update you on the progress of the Interleukin 21 and the Atacicept programs and after that I will update you on the RECOTHROM sales. ...ZGEN
Web site improved Daily Citizen, GA - Jul 22, 2008 For more information, visit the Web page at www.gainsurance.org, or call the Commissioner?s Consumer Services Division at 404-656-2070, or 1-800-656-2298. ...
Share This Story: Republican & Herald, PA - Aug 4, 2008 For more information, call 636-2070 or log onto the village Web site at www.eckelyminers.org. n Lykens: In action at their July 31 meeting, members of the ...
volunteers calendar Contra Costa Times, CA - Aug 4, 2008 Disaster volunteers ? A new Web site has been set up for disaster volunteers. Volunteers can register their skills, availability, contact preferences and ...
Bill Boyne: We must switch to renewable fuels Post-Bulletin, MN - Jul 23, 2008 The global population is expected to grow from 6.5 billion to 9.5 billon by 2070. By 2070, Roberts says, the global demand for meat will be three times the ...
Check Point unveils high performance UTM appliances CTR, CA - Jul 9, 2008 It also includes the UTM-1 Total Security 2070 featuring 2800 Mbps firewall throughput, five managed sites and eight ports. All UTM-1 Total Security ...
Carroll Hospital program awarded $30000 pledge Business Gazette, MD - Jul 23, 2008 Farmers, restaurant owners or other businesses selling locally produced products that would like to participate can contact Zepp at 410-386-2070. ...
Hawaii Activists Sue to Protect the Vote OpEdNews, PA - Jul 20, 2008 Please make your check out to Lance D. Collins, Esq., and mail it to 2070 W. Vineyard, Suite 5, Wailuku, HI 96793-1618. Reposted per Mr. Babson's request, ...
Controller network-enables traffic controller equipment. ThomasNet Industrial News Room, NY - Jul 24, 2008 The Digi Connect N2S-170 is a cost-effective alternative to a forklift upgrade to expensive Model 2070 equipment which can cost up to eight times more than ...DGII
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Information Extraction from HTML: Combining XML and Standard Techniques for IE from the Web - L Xiao, D Wissmann, M Brown, S Jablonski - Lecture Notes In Computer Science, 2001 - Springer ... and M. Ali (Eds.): IEA/AIE 2001, LNAI 2070, pp. ... We considerate that we can use the
(implicit) structured ... a complete system to extract information from Web sites ...
Internationalisation and the Web - J Knight - webdoc.sub.gwdg.de ... some of the options for I18N of Web documents ... issue of the various character sets
that can be used ... the Document Type Definition (DTD) from RFC 2070[15] corrects ...
[PDF]Analysis of Sources of Latency in Downloading Web Pages - MA Habib, M Abrams - Proceedings of WebNet, 2000 - cc.gatech.edu ... Persistent-HTTP can save the connection time for downloading a page that has more
than one ... From section 3, we see that Web page latency is dominated by RTT ...2070...
PLANETARY SCIENCE: Enhanced: New Views of Asteroids - E Asphaug - Science, 1997 - sciencemag.org ...2070 - 2071 DOI: 10.1126/science.278.5346.2070. ... The entertainment industry's view
of asteroids can be gleaned from the The Sky is Falling Web page about ...
Building an Information and Knowledge Fusion System - T Meszaros, Z Barczikay, F Bodon, TP Dobrowiecki, … - Lecture Notes In Computer Science, 2001 - Springer ... J. V?ncza, and M. Ali (Eds.): IEA/AIE 2001, LNAI 2070, pp. ... An interesting feature
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[PDF]A public automated web-based evaluation service for watermarking schemes: StirMark benchmark - FAP Petitcolas, M Steinebach, F Raynal, J Dittmann … - Proceedings of SPIE, 2001 - security-labs.org ... to an SQL server con- nected to a Web server. ... are different for each customer, attackers can compare several ... 2067?2070, Phoenix, Arizona, USA, 15?19 May1999 ...
Crawlets: Agents for High Performance Web Search Engines - P Thati, PH Chang, G Agha - Picco [Pic01] - Springer ... in hardware and unpredictable load at web servers due ... and details of the execution
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A New Approach in Object-Based Knowledge Representation: The AROM System - M Page, J Gensel, C Capponi, C Bruley, P Genoud, D … - Lecture Notes In Computer Science, 2001 - Springer ... and M. Ali (Eds.): IEA/AIE 2001, LNAI 2070, pp ... and tools for consulting and editing
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Electronic and magnetic transport measurements with probe stations - N Organizers, N Outreach, W Graphics, D Directions … - nsti.org ... However, the probes can influence the electrical, temperature and magnetic
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Web-Based Interactive Courseware for Structural Steel Design Using Java - H Adeli, H Kim - Computer-Aided Civil and Infrastructure Engineering, 2000 - Blackwell Synergy ... The Ohio State University, 470 Hitchcock Hall, 2070 Neil Avenue ... by Adeli in 1987,
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Interleukin-12 can safely be administered with Interferon as an experimental therapy for some cancers
A study has shown that the immune-stimulating hormone known as Interleukin-12 ( IL-12 ) can safely be administered with Interferon, another immune-system protein, as an experimental therapy for some cancers.
Normally, Interferon is used alone to stimulate the immune system to attack certain cancers. This strategy, a form of immunotherapy, is sometimes used to treat melanoma, advanced kidney cancer and other tumors that respond poorly to chemotherapy or radiation therapy. But Interferon can have serious side effects that limit its use.
Surprisingly, the two drugs used in sequence caused no serious side effects in patients.
" Interferon can be quite toxic when used alone," says principal investigator William E. Carson, III, at the Ohio State University Comprehensive Cancer Center.
" We were initially concerned that the addition of IL-12 might increase that toxicity. Instead, we found that the two drugs can be used together without additional side effects."
The findings in the Journal of Clinical Oncology.
They suggest that IL-12 primes white blood cells such that a lower dose of Interferon will stimulate the same level of immune activity as a higher dose of Interferon when used alone.
The results come from a phase-I clinical trial, which marks the first time a treatment is tried in human subjects.
The trial, conducted by Carson and a team of colleagues, involved 49 patients ages 23 to 84 with different types of advanced cancer, including cancers of the colon, lung, kidney and bladder and melanoma.
On the first day of treatment, patients were given IL-12, initially by injection and then intravenously. That was followed by injections of Interferon over the next five days.
On average, patients received five such cycles over the course of the study.
The drug combination not only proved to be safe – which was the purpose of the study – but the researchers found that it stopped disease progression in five of the patients for at least six months.
" Our findings were encouraging," Carson says. " They indicate that we can safely administer IL-12 in combination with Interferon, that it enhances the action of Interferon in some patients with advanced cancer, and that it can be an effective way to stimulate the immune system."
Based on the study's results, and the results of earlier animal studies led by the research group, Carson and his colleagues are conducting a multicenter phase II clinical trial of the two drugs in people with melanoma.
Phase-II trials are the first step in determining the effectiveness of new therapy against a specific disease.
" We believe that use of the two drugs together will give us more bang for the buck," says first author Gregory B. Lesinski, in the Human Cancer Genetics Program.
" We hope that the IL-12 will allow us to use lower doses of Interferon in patients, which should result in fewer side effects and potentially a longer use of interferon, giving the immune system more time to fight the tumor."
