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Recent News and Articles on the Keywords: chlamydia + fat + host  Related to the article below (Last Update: 12/1/2008)

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Health Events
Tampa Tribune, FL - Nov 14, 2008
Health screenings, including blood pressure, body fat and blood sugar, will be available, as well as information on healthy, active lifestyles. ...
Source: Google News


 

Recent News and Articles on the Keywords: chlamydia + web + 0.25  Related to the article below (Last Update: 8/7/2008)


WELT ONLINE
CORRECTING and REPLACING Quidel Reports Second Quarter 2008 Results
WELT ONLINE, Germany - Jul 23, 2008
Improvement in gross margin was primarily due to leveraging Quidel?s automated web manufacturing process on an increase in unit volume. ...QDEL
Source: Google News

In Vitro Activity of Novel Oxazolidinones against Chlamydia.
A KUBO, B PRESS, GW LUEHR, MF GORDEEV, J TRIAS - Abstr Intersci Conf Antimicrob Agents Chemother Intersci …, 2002 - gateway.nlm.nih.gov
... MICs = 0.25 and 2 microg/ml) and C. trachomatis (MICs = 0.25 and 1 ... see text] The
discovery of novel oxazolidinones with activity against Chlamydia species is ...

Re: Evidence for an Association Between Chlamydia psittaci and Ocular Adnexal Lymphomas -
P de Cremoux, A Subtil, AJM Ferreri, A Vincent- … - jnci, 2006 - jnci.oxfordjournals.org
... patients with ocular adnexal lymphoma had a high prevalence of Chlamydia psittaci
infection ... that included 25 pmol of each primer (1,6), 0.25 mM deoxynucleotide ...

Guidelines Updated for Screening for Chlamydia Infection CME/CE
F Physicians - Ann Intern Med, 2007 - medscape.com
... credit(s) for physicians; Nurses - 0.25 nursing contact ... encouraged to access the
CDC Web site for ... Chlamydia infection is the most prevalent bacterial sexually ...

In vitro activity of cethromycin, a novel antibacterial ketolide, against Chlamydia pneumoniae -
N Miyashita, H Fukano, K Yoshida, Y Niki, T … - Journal of Antimicrobial Chemotherapy, 2003 - Br Soc Antimicrob Chemo
... were 0.016, 0.063, 0.063, 0.25 and 0.25 mg/L ... susceptibilities to azithromycin of
isolates of Chlamydia pneumoniae from ... Similar articles in ISI Web of Science. ...

CG5501-in vitro study against clinical isolates including Chlamydia spp and Mycobacterium …
N Brenwald, J Andrews, F Bosweli, R Wise - Abstr Intersci Conf Antimicrob Agents Chemother Intersci …, 1996 - gateway.nlm.nih.gov
... fragilis CG had similar activity to TRO (MIC(90) 0.25 micrograms/ml), but was more
active than SPAR and CIP. All 4 strains of chlamydia were susceptible to CG ...

Dexamethasone Increases In Vitro Activity of Telithromycin and Levofloxacin against Chlamydia
F SCAGLIONE, M PANNACCI, V LUCINI, S GROSSO, F … - Abstr Intersci Conf Antimicrob Agents Chemother Intersci …, 2003 - gateway.nlm.nih.gov
... BACKGROUND: Chlamydia pneumoniae (Cp) persistence after antibiotic treatment could
be one of the ... of infected cells vs control about to 72% at 0.25 microg/ml (p ...
-

CD8+ T cells recognize an inclusion membrane-associated protein from the vacuolar pathogen Chlamydia -
SP Fling, RA Sutherland, LN Steele, B Hess, SEF D' … - Proceedings of the National Academy of Sciences, 2001 - National Acad Sciences
... Construction of a Chlamydia DNA Expression Library ... For transductions, exponentially
growing P815 cells (0.25 ? 10 6 /ml) were then added at 50 ?l/well to each ...

… of a Novel New Antibiotic, NVP-PDF386 (VRC4887), against Recent Clinical Isolates of Chlamydia
R PM, MR HAMMERSCHLAG - Abstr Intersci Conf Antimicrob Agents Chemother Intersci …, 2002 - gateway.nlm.nih.gov
... on activity of these compounds against atypical respiratory pathogens, including
Chlamydia pneumoniae and ... microg/ml, compared to a range of 0.125-0.25microg/ml ...
-

Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma -
T Huittinen, D Hahn, T Anttila, E Wahlstrom, P … - European Respiratory Journal, 2001 - Eur Respiratory Soc
... by enzyme immunoassay (EIA) against the heat shock protein 60 (Hsp60) of Chlamydia
pneumoniae and ... and MIF IgA antibodies to C. pneumoniae K6 EB (r=0.25, p=0.02 ...

… limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia -
A Brinke, JT van Dissel, PJ Sterk, AH Zwinderman, … - The Journal of Allergy and Clinical Immunology, 2001 - Elsevier
... specific recombi- nant LPS antigens) and an in-house Chlamydia strain?specific ... lines
were in a comparable range (slope of regression line, ?0.25 to ?0.63 ...

Source: Google Scholar
 
 

Chlamydia trachomatis escapes recognition by the host by cloaking itself in fat-rich structures

The Chlamydiae learned to parasitize eukaryotic cells half a billion years ago by reprogramming cellular functions from within.
In humans today, chlamydial infections are responsible for a range of ailments from sexually transmitted infections to atypical pneumonias to chronic severe disorders such as pelvic inflammatory disease and atherosclerosis.

The Centers for Disease Control says that Chlamydia trachomatis is the most common sexually-transmitted infection in the US, with three million new cases a year.

 
Chlamydia gets around because it knows its hosts so well. It's an "obligate intracellular parasite" which means that it relies on its eukaryotic host for everything from reproduction to synthesizing ATP, all while living inside a membrane-bounded vacuole that provides a protected, fertile environment for the bacteria to grow and multiply. Because lipid acquisition from the host is necessary for chlamydial replication, these pathogens are essentially lipid parasites.

Lipid droplets are fat-rich structures found in all eukaryotic cells.
In humans, lipid droplets are abundant in adipocytes, our professional fat storage cells, where they have traditionally been regarded as passive storage depots of excess fat. However, recent studies have reassessed their role.
Lipid droplets are now known to be motile, dynamic and enriched for proteins known to regulate lipid synthesis, membrane traffic and cell signaling.

The discovery of an interaction between lipid droplets and Chlamydia was made as Yadunanda Kumar and Raphael Valdivia, at Duke University Medical Center, performed the genetic equivalent of an end-run.
Chlamydia is not amenable to direct genetic manipulation so the researchers moved the pathogen's genes elsewhere, inserting them into the eukaryotic cells of baker's yeast. The resulting chlamydial proteins were screened for those that targeted to yeast intracellular organelles.
They identified four proteins that were specifically recruited to lipid droplets.

The researchers found that Chlamydia not only directs lipid droplets to its protective vacuole but also causes the proliferation of new lipid droplets on the host. The co-option of lipid droplets appears to be essential for Chlamydia pathogenesis. When the researchers used drugs to inhibit lipid droplet formation in the host, they sharply impaired bacterial growth.

That finding suggests an entirely novel pathogenic mechanism. " We propose that Chlamydia use lipid droplets in a previously unknown pathway for lipid acquisition," says Kumar. "Alternatively, it is possible that the recruitment of lipid droplets constitutes an example of 'organelle mimicry' where Chlamydia escapes recognition by the host by cloaking itself in these fat-rich structures."

Understanding host lipid transport by Chlamydiae may have further implication for chronic infections, the researchers say.
For example, lipid-rich macrophages ( "foam cells" ) are a symptom in chlamydial pneumonia. Because foam cells are a key element in development of atherosclerosis, lipid droplet co-option also suggests a possible explanation for the association between chlamydial infections and heart disease.

Source: American Society for Cell Biology, 2005
 
 
 
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