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Recent News and Articles on the Keywords: bacterial + vaginosis + species  Related to the article below (Last Update: 12/1/2008)

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Recent News and Articles on the Keywords: bacterial vaginosis + new + associated  Related to the article below (Last Update: 8/7/2008)

New Indication for VivaGel: Bacterial Vaginosis
PharmaLive.com (press release), PA - Jul 9, 2008
Bacterial Vaginosis is characterised by an imbalance between the naturally occurring vaginal lactobacilli and disease-causing bacteria. ...ASX:SPL
Starpharma Holdings Limited (ASX:SPL, OTCQX:SPHRY) Announce New ...
ABN Newswire (press release), Australia - Jul 8, 2008
Bacterial Vaginosis is characterised by an imbalance between the naturally occurring vaginal lactobacilli and disease-causing bacteria. ...
Extra indication for VivaGel Australian Life Scientist
Stars align for gel Melbourne Herald Sun
all 4 news articles »  ASX:SPL - PINK:SPHRY
Screening for Bacterial Vaginosis in Pregnancy to Prevent Preterm ...
RedOrbit, TX - Jul 15, 2008
This recommendation addresses screening for bacterial vaginosis in asymptomatic pregnant women. * Risk Assessment. Several factors have been associated with ...
Companies Quick to Partner with UMB for New Medical Advances
UMB News, MD - Jul 25, 2008
... Aparna Biosciences Corp. in Rockville to develop yeast infection prevention, Cellex Inc. in Rockville for developing a new test for bacterial vaginosis, ...
Sexually Transmitted Infection Among Adolescents Receiving Special ...
RedOrbit, TX - Aug 3, 2008
Prevalence and correlates of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis infections, and bacterial vaginosis among a cohort of young ...
China Sky One Medical, Inc. Has 11 New Drugs in Clinic Trials
RedOrbit, TX - Jul 10, 2008
Fibrauretnire Suppositories: for treatment of vulvar moniliasis vaginosis; -- Omeprazole Sodium Injection: for treatment of digestive ulcers, gastrinoma, ...CSY
Source: Google News

Association between Bacterial Vaginosis and Preterm Delivery of a Low-Birth-Weight Infant -
SL Hillier, RP Nugent, DA Eschenbach, MA Krohn, RS … - New England Journal of Medicine, 1995 - content.nejm.org
Original Article from The New England Journal of Medicine -- Association between
Bacterial Vaginosis and Preterm Delivery of a Low-Birth-Weight Infant. ...

HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis -
N Sewankambo, RH Gray, MJ Wawer, L Paxton, D … - Lancet, 1997 - Mass Med Soc
... Citation(s): Sewankambo N et al. HIV-1 infection associated with abnormal vaginal
flora morphology and bacterial vaginosis. ... New to Journal Watch? ...

Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain … -
RP Nugent, MA Krohn, SL Hillier - Journal of Clinical Microbiology, 1991 - jcm.highwire.org
... Association of interleukin-1{beta} and interleukin-1 ... Prevalence of Bacterial Vaginosis:
2001 2004 National Health and ... transmitted infections: a brave new world ...

Sialidases (neuraminidases) in bacterial vaginosis and bacterial vaginosis-associated microflora. -
AM Briselden, BJ Moncla, CE Stevens, SL Hillier - Journal of Clinical Microbiology, 1992 - pubmedcentral.nih.gov
... Bacterial vaginosis: microbiological and clinical findings. ... Vaginal Bacteroides species
are associated with an ... R, Uhlenbruck G. Amniomucoids--a new class of ...

The preterm prediction study: the value of new vs standard risk factors in predicting early and all … -
RL Goldenberg - American Journal of Public Health, 1998 - Am Public Health Assoc
... J. Wang Factors Linked to Bacterial Vaginosis in Nonpregnant ... and Intrauterine Growth
Retardation: New Insights Based ... of and Factors Associated With Recurrence ...

Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV … -
TE Taha, DR Hoover, GA Dallabetta, NI Kumwenda, … - AIDS, 1998 - aidsonline.com
... Sturm AW: Bacterial vaginosis and associated infections in ... SL: Reliability of diagnosing
bacterial vaginosis is improved ... New York: Oxford University Press; 1986 ...

Molecular Identification of Bacteria Associated with Bacterial Vaginosis -
DN Fredricks, TL Fiedler, JM Marrazzo - New England Journal of Medicine, 2005 - content.nejm.org
Original Article from The New England Journal of Medicine -- Molecular
Identification of Bacteria Associated with Bacterial Vaginosis. ...

Bacterial Vaginosis Is Associated With Prematurity and Vaginal Fluid Mucinase and Sialidase: Results … -
JA McGregor, JI French, W Jones, K Milligan, PJ … - American Journal of Obstetrics & Gynecology, 1994 - pt.wkhealth.com
... Evidence relating bacterial vaginosis to intraamniotic infection. ... production of
streptococci associated with acute ... New York: Springer-Verlag, 1982:263-305. ...

… Atopobium vaginae, a recently described metronidazole resistant anaerobe, with bacterial vaginosis -
MJ Ferris, A Masztal, KE Aldridge, JD Fortenberry, … - feedback, 2004 - biomedcentral.com
Association of Atopobium vaginae, a recently described ... resistant anaerobe, with
bacterial vaginosis Michael J ... University Health Sciences Center, New Orleans, LA ...

Bacterial vaginosis and vaginal microorganisms in idiopathic premature labor and association with … -
E Holst, AR Goffeng, B Andersch - Journal of Clinical Microbiology, 1994 - pubmedcentral.nih.gov
... Chlamydia trachomatis, and bacterial vaginosis to preterm ... of preterm birth: new
initiatives based on ... production by microorganisms associated with reproductive ...

Source: Google Scholar
 
 

Several new bacterial species associated with bacterial vaginosis identified

Despite being one of the most common infections among women, researchers know little about the causes of bacterial vaginosis, a usually benign disease that is also linked to serious health problems including pelvic inflammatory disease, an increase in the viral load of HIV from infected women and a two-fold increase in risk for pre-term labor and delivery.

Researchers at the Fred Hutchinson Cancer Research Center have shed new light on bacterial vaginosis by using genetic-sequencing technology to detect several new bacterial species – enough to almost double the number of known strains associated with the infection.
 
The findings are published in the New England Journal of Medicine.

These newly described uncultivated bacterial strains could be a reason for bacterial vaginosis 's high relapse rate – up to 30 percent – and could lead to the development of new diagnostic tests and better treatment approaches that target some of these novel bacteria. The knowledge also eventually will help doctors determine if particular uncultivated bacterial species are responsible for the serious complications associated with bacterial vaginosis, according to David Fredricks, at the Hutchinson Center's Clinical Research Division.

Bacterial vaginosis is usually harmless and easily treated with antibiotics. Symptoms include malodorous discharge, itching and burning, however, some women with bacterial vaginosis have no symptoms. Despite its prevalence ( 10 percent to 20 percent in Caucasian women and 30 percent to 50 percent in African-American women in the United States ) the cause of bacterial vaginosis is not well understood by scientists and doctors, Fredricks said.

" With most bacterial infections, you identify what the bacterium is and you treat that bacterium," said Fredricks." The problem with bacterial vaginosis is we don't know what we're treating. We know some of the strains associated with bacterial vaginosis, however many strains that are cultured in the lab are not sensitive to the usual antibiotic treatments, yet patients may respond to therapy. We need to find out which bacteria cause bacterial vaginosis and why some women either respond to antibiotic treatment or fail to be cured."

Fredricks and colleagues postulated that one reason for bacterial vaginosis 's persistent mystery is that scientists haven't identified the total community of bacteria that causes it. Indeed, the study found that most of the bacterial species detected in vaginal fluid are missed with conventional cultivation methods. The researchers catalogued a total of 35 bacterial species associated with bacterial vaginosis, doubling the known species. Nineteen appear to be novel species, the study reported. The study identified three new strains, members of the Clostridium phylum. They had specificities of 95 percent to 98 percent, meaning their detection in vaginal fluid reliably predicted the presence of bacterial vaginosis. On the other hand, not all women with bacterial vaginosis harbored these novel Clostridium-like bacteria.

" Numerous bacterial genera identified in this study have not, to our knowledge, been previously detected in the vaginal milieu with the use of cultivation methods," researchers said.

Rather than grow bacteria in a Petri dish –the standard identification method –Fredericks harvested DNA from bacteria, cloned segments of the DNA and used polymerase chain reaction ( PCR ) assays to analyze and sequence the segments. PCR analysis has a high degree of sensitivity and specificity. What made this possible is that every bacterium has the 16S ribosomal RNA gene, the gene that codes for ribosomes, which are the protein synthesizing machinery of cells.

" The 16S ribosomal RNA gene is unique for each different species of bacterium," said Fredricks. " By knowing the sequence of the gene you can identify the bacterium. We get a sort of molecular bar code." With these read outs, researchers went online to the GenBank database operated by the National Institutes of Health and looked for matches among the bacterial strains catalogued there. Now that a more complete catalogue of bacterial strains has been assembled, Fredricks said work can begin looking for specific associations between individual species and the more adverse health problems linked to bacterial vaginosis.

Source: Fred Hutchinson Cancer Research Center, 2005
 
 
 
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