MicroRNA Blocker Prevented Heart Failure In Mice Medical News Today, UK - Thum and colleagues found that miR-21 was over-expressed in the failing human heart and affected the structure and working of heart muscle through ...
Vote of confidence The Week, India - Nov 29, 2008 By Tariq Bhat The barren stretch of land in Baltal that was at the heart of the Amarnath land row lay buried under a thick layer of snow. ...
Drug protects mice from heart failure New Scientist (subscription), UK - Nov 18, 2008 Researchers recently discovered that a micro RNA called miR-208 is implicated in heart failure and that mice engineered to lack the gene for miR-208 are ...
10th PA session held amid fumigation Daily Times, Pakistan - Nov 14, 2008 Speaking on the occasion, PPP member Sajida Mir said that the government had allocated Rs 8 million development funds for each female parliamentarian. ...
Calendar of Events The Catholic Key, MO - Nov 13, 2008 24 hour, 7 days a week Adoration, First Friday Mass 7 pm, First Saturday Mass, 8 am, Holy Hour, Third Sunday, 7 pm Mir House of Prayer, 6492 NE State Road 6 ...
The Destination to Democracy Energy Bangla, Bangladesh - Nov 15, 2008 Why Mir Nasir and her brother Shamim must not be blamed for massive scams of Bangladesh Biman? Why Scam Master Murshed Khan must not get punished? ...
Embedded government www.worldbulletin.net, Turkey - Nov 18, 2008 In addition, the replacement of Dengir Mir Mehmet Fırat with Abdulkadir Aksu, known as a pro-establishment Kurd, as AK Party deputy chairman and many other ...
?They can kill me, they can?t make me vote? Chandigarh Tribune, India - Nov 15, 2008 Disenchantment is evident in the heart of urban Srinagar, from where the National Conference?s chief ministerial candidate Farooq Abdullah is seeking ...
Source: Google News
Recent News and Articles on the Keywords: heart + 0.33 + web Related to the article below (Last Update: 8/7/2008)
MedCath Corporation Reports Third Quarter Earnings CNNMoney.com (press release) - "In that regard, we recently announced a significant expansion of our Bakersfield Heart Hospital and we have now completed the 60 bed expansion and ...MDTH
Crystal Structure of the Cytochrome bc1 Complex from Bovine Heart Mitochondria - D Xia, CA Yu, H Kim, JZ Xia, AM Kachurin, L Zhang, … - Science, 1997 - sciencemag.org ... a browser that does not support current Web standards ... Recently, bc 1 from bovine heart mitochondria has been ... 73.1, 19.3, 595,440, 28,831, 10.5, 9.7, 0.33, 0.98, 14,337 ...
Fab: content-based, collaborative recommendation - M Balabanovic, Y Shoham - Communications of the ACM, 1997 - portal.acm.org ... IRS Forms and Publications page are ?faint-of-heart?? (0.33), ?tax?? (0.28 ... For Web
pages, for instance, IR techniques completely ignore aes- thetic ...
[CITATION] Evaluation of Proximity Search and Auto-Concept Expansion on a Web Newspapers Document Collection: … S Khan, H Jameel, A Sajjad, H Iqbal - ACM Journal of Computer Documentation (accepted for …
Assessment and consequences of the constant-volume attribute of the four-chambered heart - AW Bowman, SJ Kovacs - … Journal of Physiology- Heart and Circulatory Physiology, 2003 - Am Physiological Soc ... Search for citing articles in: ISI Web of Science (6 ... This is the total blood pumped
out of the four-chambered heart during systole, lasting 0.33 s. This ...
Redox-Coupled Crystal Structural Changes in Bovine Heart Cytochrome c Oxidase - S Yoshikawa, K Shinzawa-Itoh, R Nakashima, R Yaono … - Science, 1998 - sciencemag.org ... using a browser that does not support current Web standards ... Crystal structures of
bovine heart cytochrome c oxidase in the ... rms ddagger (?), 0.30, 0.30, 0.32, 0.33...
The Relation of Childhood BMI to Adult Adiposity: The Bogalusa Heart Study - DS Freedman, LK Khan, MK Serdula, WH Dietz, SR … - Pediatrics, 2005 - Am Acad Pediatrics ... 2-5 years) children were moderately associated (r = 0.33-0.41) with ... body mass index ?
obesity ? adult adiposity ? Bogalusa Heart Study ? longitudinal ...
Fish and Omega-3 Fatty Acid Intake and Risk of Coronary Heart Disease in Women - FB Hu, L Bronner, WC Willett, MJ Stampfer, KM … - JAMA, 2002 - Am Med Assoc ... extreme categories of fish consumption was 0.55 [95% CI, 0.33-0.90]) than ... Table 2.
Relative Risk of Coronary Heart Disease (CHD) According to Quintiles of Omega ...
Researchers from the Gladstone Institute of Cardiovascular Disease ( GICD ) have identified a key factor in heart development that could help advance gene therapy for treating cardiac disorders.
Published in the Proceedings of the National Academy of Sciences ( PNAS ), the study evaluates the role of short RNAs, also known as miRNAs, in the early stages of the developing heart.
The findings could help cardiac stem cell researchers one day develop strategies for gene and cell- mediated cardiac therapies, according to Deepak Srivastava, senior author and GICD director.
RNAs are nucleic acids found in all living cells that help transfer information from DNA to the protein-forming system of the cell. They also express -- that is, instruct to turn on or off - -genes within that transferred information. MiRNAs are short RNAs that repress gene expression to control a variety of developmental processes.
In the study, which used Drosophila fly embryos as model systems, the research team demonstrated that a form of miRNA known as miR-1 helps in determination of heart progenitor cells (stem cells) in early embryonic stages. They also showed that miR-1 helps in maintenance of heart precursors in later embryonic stages.
In addition, researchers demonstrated that miR-1 can repress the ligand Delta, which otherwise binds to its receptor, Notch. The binding of Delta and Notch mediates development of many kinds of tissues and is involved in differentiation of cardiac stem cells into muscle cells.
" Given the importance of understanding cardiac progenitor determination and differentiation in current cardiac regenerative medicine, our study will contribute to the understanding of how heart progenitors differentiate to become mature heart cells in human heart development," explains Srivastava.
" Finding the mechanism for how miR-1 regulates heart cell differentiation is very exciting. These insights into the fundamental questions of development may help us ultimately to harness the potential of stem cells for the treatment of heart disease and other afflictions."
" miRNAs bind to messenger RNAs and either degrade them or hinder their ability to make a protein," adds lead author Chulan Kwon. " miR-1 interferes with expression of a crucial gene that controls whether or not certain progenitor stem cells become heart cells. Thus it could be a target for future gene-mediated therapies to prevent early heart development problems."
