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Recent News and Articles on the Keywords: receptor + ampa + stroke  Related to the article below (Last Update: 12/1/2008)

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Recent News and Articles on the Keywords: stroke + 48,700 + receptor  Related to the article below (Last Update: 8/7/2008)

Gastrointestinal bleeding after stroke may be fatal
Hindu, India -
WASHINGTON (Xinhua): People who have gastrointestinal (GI) bleeding after a stroke are more likely to die or become severely disabled than stroke sufferers ...
GI Bleeding After Stroke Raises Death Risk U.S. News & World Report
GI Bleeding Associated With Worse Ischemic Stroke Outcomes MedPage Today
all 15 news articles »
Field of 40 set for Capital Stroke Play Championship
Troy Record, NY -
The popular Capital Stroke Play Championship returns to the area Friday and Saturday at Mohawk Golf Club. A full field of 40 top amateur golfers will match ...
San Antonio to stop sending stroke patients to Austin, other cities
Austin American-Statesman, TX -
By Mary Ann Roser A Seton hospital official said he is "cautiously optimistic" that San Antonio will stop sending stroke patients to Austin for treatment ...
Brain scientist?s book a stroke of suffering and genius
Worcester Telegram, MA -
After a night in the hospital, I suffered a second stroke that paralyzed my left side even further. I could not lift my left arm nor move my left leg. ...
Lipitor 80 mg Reduced the Risk of Heart Attack and Stroke in ...
MarketWatch -
"This trend is alarming, since patients with diabetes and chronic kidney disease are much more likely to suffer a heart attack or stroke than patients with ...
Eating Fish May Prevent Memory Loss And Stroke In Old Age
Science Daily (press release) - Aug 5, 2008
4, 2008) ? Eating tuna and other types of fish may help lower the risk of cognitive decline and stroke in healthy older adults, according to a new study. ...
Fish May Ward Off Dementia and Stroke U.S. News & World Report
Fish May Boost Memory, Prevent Stroke WebMD
Diet which includes fish prevents dementia and stroke News-Medical.net
Telegraph.co.uk - InTheNews.co.uk
all 92 news articles »
Final Stroke Play Qualifying ? Open Division
Kansas City Star, MO -
Kimminau, John, Rau, Matt 63-62?125. Illiff, Brett, Lazzo, Matt 63-63?126. Miller, Matt, Needles, Ty 65-62?127. Casburn, Kris, Hovis, Scott 65-63?128. ...
Telemedicine Allows Better Stroke Treatment Decisions Than ...
MedIndia, India - Aug 5, 2008
Dr. Brett C. Meyer, Co- Director of the UC San Diego Medical Center Stroke Center, describes this approach as telemedicine. He and his colleagues studied ...
California Study Builds Case for Telemedicine Use in Stroke Treatment California Healthline
Video Consultations Effective for Stroke Treatment Washington Post
MEDICINE: Telemedicine boosted by stroke study North County Times - Californian
Newswise (press release) - Medical News Today
all 40 news articles »
Stroke club applauds wonder drug
St. Albans Observer, UK -
By Alexandra Barham ? A STROKE club in St Albans has praised a revolutionary new drug which stimulated the speedy recovery of a man left paralysed by the ...
Technology benefits stroke patients
Hospital Healthcare Europe, UK -
Stroke patients living outside large cities can benefit from hospital doctors using a telemedicine programme rather than traditional telephone consultations ...
Source: Google News

[CITATION] Plano Senior Center Plano Senior Center Plano Senior Center Plano Senior Center
RY Life

Challenges for care homes: education and training of healthcare assistants -
JM Fitzpatrick, JD Roberts - British Journal of Nursing, 2004 - internurse.com
... disorder, followed by rheumatological conditions, dementia, stroke and neurological ...
A reported figure of approximately 48700 healthcare assistants are employed ...

Mechanism for an Energy Absorbing, Underride Resisting, Truck-Front Bumper Bar
A Wasiowych, A Lozzi, M Griffiths - search.informit.com.au
... Dynamic gu) 24100 33900 33300 43500 48700 Energy for 90 mm of crush (kJ) ' ... The bumper
bar was designed to effectively stroke at 216 kN to a maximum of 330 kN. ...
-

Recurrent attacks of status epilepticus as predominant symptom in 3-methylcrotonyl-CoA carboxylase … -
E Dirik, U Yis, G Pasaoglu, C Chambaz, MR … - Brain and Development, 2008 - Elsevier
... Turkey b Caria Hospital, Department of Pediatrics, 48700 Marmaris, Mugla ... familial
hypotonia or hypertonia, cardiomyopathy and metabolic stroke are additional ...
-

[PDF] Yugoslavia EUROPEAN REGION -
S PREVALENCE, T ECONOMY - Population (millions), 1995 - who.int
... Cigarette production sticks in millions ? ? ? 12686 ? Tobacco leaf production
metric tons 48700 59000 45721 13482 12148 ... Stroke ? ? ? ? ...
-

Energy absorption for a truck-front bumper bar -
A Wasiowych, A Lozzi, M Griffiths - International Journal of Crashworthiness, 1996 - informaworld.com
... 11.46 670.5 85.5 43500 46515 3.12 inversion 29.06 410.0 83.6 48700 46575 13.41
inversion ... The bumper bar was designed to effectively stroke at 216 ...

[CITATION] On the Air-Engine
JP Joule, W Thomson - Philosophical Transactions of the Royal Society of London ( …, 1852 - The Royal Society
... consump- tion of fuel in an engine similar to that just described, is as follows
:?To determine the pressure and temperature for any point of the stroke of a ...

[BOOK] The Bascule Bridge, Its Origins, the Different Types, Etc., Including the Design of the Machinery …
JS Dean - 1909 - University of Wisconsin--Madison

[CITATION] MODELLING AND SIMULATION OF NOVEL HYDRAULIC ACTUATION SYSTEM FOR ENGINE VALVES
AS ESCOBOSA - Advances in Measurement and Control: Proceedings of the …, 1979 - Acta Press

[PDF] INFORMATION FOR THE LIBRARY -
SC de Serves - vv.se
... Odometer (km) 38200 48700 29800 Vehicle weight (kg) 1169 1169 1169 Valves per cylinder
4 4 4 Displacement (cm 3 ) 1596 1596 1596 Bore/stroke (mm) 84.8 / 88.0 ...

Source: Google Scholar
 
 

Stroke: selective inhibition of pathological form of AMPA receptor could protect vulnerable neurons

In the stroke, researchers have traced the major cause of the death of brain cells due to artery blockage or bleeding in the brain.
They know that the resulting oxygen loss, or ischemia, unleashes a cascade of the brain chemical glutamate, which in turn triggers receptors on the surface of brain cells to snap open, allowing a lethal flood of calcium into the cells. Such receptors are pore-like proteins on the neuronal surface.
However, clinical trials of drugs to keep these receptors closed to calcium have largely failed, in large part because they disrupt normal function of the channels in otherwise unaffected brain areas.
 
Now, however, researchers have discovered the distinct molecular malfunction that renders some neurons particularly vulnerable to stroke damage. Those vulnerable are neurons are in the hippocampus, the brain region central to learning and memory. The researchers' findings could lead to drugs targeted to correct this specific malfunction, without compromising other brain cells.

The researchers, led by YouMing Lu of the University of Central Florida and the University of Calgary, published their findings in the Neuron.

Their studies concentrated on one of the glutamate receptors, called the AMPA receptor, that opens to cause calcium "poisoning" of neurons after ischemia. The other major receptor involved is called the NMDA receptor.

The researchers found in their experiments with rats that the AMPA receptor allows calcium influx in ischemia because such ischemia causes the receptor to be abnormally constructed in the first place. They found that in vulnerable neurons, early in the construction of the receptor, the machinery for correctly "editing" one part of the genetic blueprint, called messenger RNA, for a key AMPA receptor subunit has been disrupted. The editing consists of a pinpoint alteration in the messenger RNA when it is first produced, to prepare it to become a functioning blueprint in the protein-production machinery.

Significantly, the researchers found that, by using a genetic technique to switch this editing machinery back on in vulnerable neurons, they could protect them from ischemic injury.
Conversely, by switching it off in injury-resistant neurons, they could render those neurons vulnerable to ischemic damage.

They also traced the injury pathway further upstream, finding that an "executive" enzyme called CREB was responsible for regulating the editing machinery.
Other scientists had discovered that CREB was reduced in neurons vulnerable to ischemic damage. Thus, when Lu and his colleagues switched CREB on in vulnerable neurons, they could protect them from ischemic damage.

" To date, most clinical stroke trials targeting glutamate receptors ( AMPA or NMDA ) have failed, possibly because receptor antagonists also block the physiological actions of glutamate in noninjured neurons," wrote the researchers.

The researchers said that their findings showed that the AMPA receptor subunit editing "is an initial intracellular event that gates glutamate receptor injurious signals in forebrain ischemic insult."
Designing inhibitors that would target only the pathological form of the receptor could provide a potential strategy that would bypass the negative side effects seen with prior receptor antagonists.
 
Source: Neuron, 2006
 
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