Prostate Cancer Spurs New Nerves Science Daily (press release) - Ayala noted that this finding is comparable to the discovery of angiogenesis or the growth of new blood vessels. Both are part of the wound repair process. ...
New Probes Stop Tumor Blood Flow Daily Nexus, CA - Nov 26, 2008 ... was granted the Innovator Award for his discovery of ways to target drugs to tumor blood vessels and then suppress the growth of those tumors. ...
Users Losing Hair and Teeth WhyQuit (press release), SC - ... hinders bone healing, induces angiogenesis which causes plaque build-up within arteries to harden, and that it accelerates tumor growth rates. ...
You Docs: America's favorite physicians give advice Houston Chronicle, United States - Low levels can literally rewrite your DNA, raising cancer risk by muting your tumor-suppressing genes and weakening chromosomes. The facts: High-dose folic ...
How Tumor Suppress or Inhibits Cell Growth Newswise (press release) - Aug 4, 2008 The finding may prove to be very important in scientists? search for novel inhibitors that stop or slow cancer tumor growth. In fact, Budanov obtained ...
Study Provides Clues To Preventing And Treating Cancer Spread Science Daily (press release) - Jul 28, 2008 The idea is that the spread of cancer isn't just about the tumor itself (the seed), but also the environment where it grows (the soil). ...
'Smart bomb' nanoparticles stop cancer's spread Computerworld, MA - Jul 9, 2008 ... on the primary tumor, studies showed it did stop pancreatic and kidney cancers from metastasizing through the bodies of mice that were being tested. ...
Breast cancer: What you need to know Food Consumer, IL - Aug 5, 2008 Chemical causes breast cancer in mice. Hormone therapy: In a monograph published on July 29, the International Agency for Research on Cancer concluded that ...
Nanoparticle ?Smart Bomb? Could Stop Cancer?s Spread Discover Magazine, NY - Jul 8, 2008 ... drugs to a tumor?s blood vessels with laser-like precision, and that studies in mice show that this system could stop tumors from metastasizing, ...
Nanomaterials key to new strategies for blocking metastasis Nanowerk LLC, HI - Jul 9, 2008 The micelles reach the tumor, react with water, and break down, slowly releasing the drug. Tested in mice, Lodamin had a significantly increased half-life ...
Ask Aubrey de Grey About Longevity Research Slashdot - Jul 9, 2008 Baldrson writes, "Anti-aging researchers, via The Methuselah Mouse Prize or M-Prize, are receiving an additional $3 million incentive to stop and reverse ...
Source: Google News
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Fibulins stop blood-vessel and tumor growth in mice
Researchers at National Jewish Medical and Research Center reported in Cancer Research that a pair of promising proteins, known as fibulins 3 and 5, slow the growth of cancer tumors in mice by preventing blood vessels from sprouting.
The proteins are promising candidates for use in cancer therapy.
" Healthy humans produce fibulin proteins, which regulate cell proliferation, migration and invasion. In the past, we have seen that they are depleted in numerous metastatic cancers, and that they inhibit the formation of new blood vessels in cell culture," said William Schiemann, at National Jewish. " Our current findings show that fibulins can inhibit both tumor growth and blood-vessel formation in mice."
Tumors need nutrients and oxygen supplied by blood vessels in order to grow. They also use blood vessels to spread to other parts of the body. This process, known as metastasis, is the most lethal stage of cancer and the leading cause of cancer-related death. Fighting cancer by starving tumors of life-giving blood vessels has generated great interest in recent years.
In their most recent experiments, Schiemann and his colleagues injected a biological material, called Matrigel, into mice.
The Matrigel contained a growth factor that promotes blood-vessel growth and either a control substance or fibulin 3 or fibulin 5.
After seven days, researchers found that the Matrigel plugs containing either fibulin had about half as many blood vessels as did the control plugs.
The researchers then injected fibrosarcoma tumor cells into mice. The tumor cells were genetically engineered to produce either fibulin 3 or fibulin 5.
Three weeks after the cells were implanted, developing tumors that produced the fibulins were approximately 24 percent to 45 percent smaller than the control tumors.
" We are thrilled that the fibulins continue to show promise as we move into animal models," said Schiemann. " We also found evidence that the fibulins work through more than one biological pathway, which suggests a very robust effect. We further expect the mice to tolerate quite large doses of the fibulins, which makes us hopeful that toxicity will not be a problem."
The researchers have not yet discovered what receptors the fibulins interact with to produce their anti-angiogenic effect. But in the current paper, they report that the fibulins alter levels of extracellular proteins involved in dissolving and remodeling the extracellular matrix, which can make way for blood-vessel growth.
Source: National Jewish Medical and Research Center, 2006
