Vagina monologues Express Buzz, India - Other symptoms are severe acne, weight gain and obesity, excessive hair growth on the face, nipple area, chest, lower abdomen and thighs,? says Dr Uma. ...
Roche to pay $12.9M in Accutane lawsuits The Star-Ledger - NJ.com, NJ - Nov 20, 2008 By DAVID VOREACOS Roche Holding must pay $12.9 million to plaintiffs who blamed the Accutane acne medicine for their inflammatory bowel disease, ...OTC:RHHBY
Curing Diversity FrontPage magazine.com, CA - Nov 27, 2008 So is a quite widely used acne drug, when directed against a rare cancer. Over half of the orphans end up as wards of Big Pharma, and the most successful ...
Roche Must Pay $13M In Accutane Lawsuits Pharmalot, NJ - Nov 19, 2008 ... plaintiffs who claim that their inflammatory bowel disease (IBD) was caused by the drugmaker?s acne med, according to Mealey?s Emerging Drug & Devices. ...
Back-to-School Stress for Teen Boys PR Web (press release), WA - Aug 6, 2008 "When you squeeze a pimple, you can trigger more inflammation and increase the risk of scarring," explains Dr. Bank. Expect a Change?Eventually: All acne...
Hormone hell Times Online, UK - Jul 27, 2008 ... facial hair and acne. Shedding pounds by eating carbohydrate foods that are digested slowly (a ?low glycaemic index? or low GI diet) and do not trigger...
Doubts remain about China staging the Olympic Games Melbourne Herald Sun, Australia - Aug 1, 2008 HE was just a self-conscious teenage boy, scatterings of acne spotting his face, gangly arms sprouting out of a torso still waiting for its last burst of ...
Smells like teen stereotypes Globe and Mail, Canada - Aug 1, 2008 Today's spitballs are electronic, as teens sit at the back of the class with trigger fingers wired to their cellphones. This is where the film grows more ...
A pregnant day at the spa East Valley Tribune, AZ - Jul 25, 2008 Pregnancy can unleash a host of changes on women, from stretch marks crisscrossing their expanding stomachs to acne flare-ups. Spider veins, extra hair ...
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Acne Is Not a Trivial Disease! Psychosomatic Aspects in Routine Therapy - V Niemeier, J Kupfer, U Gieler - content.karger.com ... in which the onset of the disease was linked to marital break- up [Harrington, 1997].
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TLR-2 is expressed on the ... for the treatment of this common skin disease 87 ...
Acute generalized exanthematous pustulosis (AGEP)-A clinical reaction pattern - A Sidoroff, S Halevy, JNB Bavinck, L Vaillant, JC … - Official Publication of the American Society of …, 2001 - Blackwell Synergy ... and/or infections as trigger for the ... like bacterial folliculitis, furunculosis, acne
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Acne med may trigger bowel disease
While suspected for some time, a study now confirms that people taking the acne drug isotretinoin appear to run an increased risk of developing inflammatory bowel disease, US researchers report.
Inflammatory bowel disease, or IBD, includes Crohn's disease and a similar condition called ulcerative colitis. Isotretinoin, more familiarly known by the brand name Accutane, was first approved for acne in the US in 1982, and numerous cases have surfaced linking the drug to IBD. Until now, a systematic review of the association had not been conducted.
Dr. Corey A. Siegel, from Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire, and colleagues reviewed all reports of isotretinoin-associated IBD that were filed with the US Food and Drug Administration via the MedWatch system, which began in 1996.
The authors explain in the American Journal of Gastroenterology that they used a standard adverse drug reaction probability scale to grade the likelihood that a particular IBD case was, in fact, caused by isotretinoin use.
Between 1997 and 2002, a total of 85 isotretinoin-related cases of IBD were reported. In just four cases, isotretinoin was graded as a "highly probable" cause of the IBD, while in 58 cases it was deemed a "probable" cause, and in 23 cases it was seen as a "possible" cause. The link between isotretinoin use and IBD was never graded as "doubtful."
"Physicians and patients should be made aware of this possible association and it should be included in the already extensive consent process required before isotretinoin is prescribed," the investigators write.
The consent process covers the high risk of birth defects if a woman becomes pregnant while taking isotretinoin.
Should someone with severe acne take isotretinoin? "We do not think that this should prohibit the use of isotretinoin," Siegel and colleagues advise. However, "careful consideration should be made" for people with a prior personal history or family history of inflammatory bowel disease, or who have symptoms suggesting the possibility of IBD.
SOURCE: American Journal of Gastroenterology, July 2006.
