Marijuana-inspired Painkiller? New Chemical Pathway Discovered Science Daily (press release) - Nov 23, 2008 The body also has chemicals known as endocannabinoids that naturally activate these same receptors, namely N-arachidonoyl ethanolamine (AEA) and ...
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Recent News and Articles on the Keywords: endocannabinoids + urb597 + brain Related to the article below (Last Update: 8/7/2008)
Weeding Out The Highs Of Medical Marijuana Science Daily (press release) - Jul 14, 2008 A further approach to avoiding the psychoactivity caused by THC involves harnessing the body's own cannabis, called 'endocannabinoids'. ...
Your Skin Produces Marijuana-Like Substance FOXNews - Jul 17, 2008 The skin has joined the growing club of organs that is known to produce "endocannabinoids" ? the body's own reefer. The biggest producer of endogenous pot ...
Endocrinology & Metabolism News Journal of Clinical Endocrinology and Metabolism, MD - ... that increased endocannabinoid tone observed in obesity is linked to a failure of central leptin signaling to restrain peripheral endocannabinoids. ...
Human cannabis could improve skin care CosmeticsDesign-Europe.com, France - Jul 9, 2008 The study into the properties of "endocannabinoids" will be published in the October issue of the Federation of American Societies for Experimental Biology ...
Human Skin Found to Produce Hash-Like Substance CollegeOTR, NY - Jul 14, 2008 "Endocannabinoids," just like cannabinoids found in pot leaves, protect the skin from the drying effects of the elements (ie wind). ...
Anandamide as a Marker of Human Disease?Reply Journal of American Medical Association (subscription), IL - Jul 15, 2008 We agree that an increased understanding of the role of endocannabinoids in physiology and pathology may help in the development of new diagnostic and ...
Da tạo ra chất giống cần sa Belinew, Florida - Jul 18, 2008 Andrzej Slominski, nh? nghi?n cứu thuộc đại học Tennessee kh?ng tham gia v?o nghi?n cứu endocannabinoids nhưng c? nghi?n cứu về hệ thống neuroendocrine tr?n ...
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… phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids - D Leung, A Saghatelian, GM Simon, BF Cravatt - Biochemistry, 2006 - pubmedcentral.nih.gov ... Multiple Mechanisms for the Biosynthesis of Endocannabinoids ?. ... have shown that the
FAAH inhibitor URB597 causes a significant increase in brain levels of ...
Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated … - B Shouman, RH Fontaine, O Baud, L Schwendimann, M … - British Journal of Pharmacology, 2006 - nature.com ... hypothesis: (i) the addition of URB597, an inhibitor ... CB receptors involved in the
neuroprotective effects of endocannabinoids. ... by nabilone in the brain might be ...
… agonists and endocannabinoids on histamine release from distinct regions of the rat brain - G Cenni, P Blandina, K Mackie, D Nosi, L Formigli, … - European Journal of Neuroscience, 2006 - Blackwell Synergy ... axonal arborizations within this brain region (Haas & ... Alternatively, endocannabinoids
may increase histamine release in a ... of AM404 or URB597, an inhibitor of ...
Why endocannabinoids are not all alike - V Di Marzo, L Cristino - Nature Neuroscience, 2008 - nature.com ... Of the two principal endocannabinoids, 2-AG ... causes elevation of whole brain anandamide
levels ... periaqueductal gray, administration of URB597 elevates anandamide ...
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models - A Jayamanne, R Greenwood, VA Mitchell, S Aslan, D … - British Journal of Pharmacology, 2006 - nature.com ... efficacy of systemically administered endocannabinoids is likely ... within pain modulatory brain structures (Walker ... have been identified, including URB597, OL-53 ...
Anandamide hydrolysis: a new target for anti-anxiety drugs? - S Gaetani, V Cuomo, D Piomelli - Trends in Molecular Medicine, 2003 - Elsevier ... Figure 1. Chemical structures of the endocannabinoids anandamide and 2-
arachidonoylglycerol (2-AG ... Although URB597 increases brain anandamide levels ...
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Depression: URB597 increases endocannabinoids in brain
Researchers have discovered a new drug that raises the level of endocannabinoids providing anti-depressant effects.
The research published in the Proceedings of the National Academy of Sciences ( PNAS ), suggests the new drug, called URB597, could represent a safer alternative to cannabis for the treatment of pain and depression, and open the door to new and improved treatments for clinical depression.
In preclinical laboratory tests researchers found that URB597 increased the production of endocannabinoids by blocking their degradation, resulting in measurable antidepressant effects.
" This is the first time it has been shown that a drug that increases endocannabinoids in the brain can improve your mood," says the lead investigator Gabriella Gobbi, an MUHC and Université de Montréal researcher.
Endocannabinoids are chemicals released by the brain under certain conditions, like exercise; they stimulate specific brain receptors that can trigger feelings of well-being.
The researchers, which included scientists from the University of California at Irvine, were able to measure serotonin and noradrenaline activity as a result of the increased endocannabinoids, and also conducted standard experiments to gauge the mood of their subjects and confirm their findings.
" The results were similar to the effect we might expect from the use of commonly prescribed antidepressants, which are effective on only around 30% of the population," explains Gobbi. " Our discovery strengthens the case for URB597 as a safer, non-addictive, non-psychotropic alternative to cannabis for the treatment of pain and depression and provides hope for the development of an alternate line of antidepressants, with a wider range of effectiveness."
Cannabis has been known for its anti-depressant and pain-relief effects for many years, but the addictive nature and general health concerns of cannabis use make this drug far from ideal as a medical treatment.
The active ingredient in cannabis -- THC ( Tetrahydrocannabinol ) -- stimulates cannabinoid receptors.
