Students help kids smile without pain SW Iowa News, IA - According to the US Surgeon General's Oral Health in America report, tooth decay is the single most common chronic childhood disease -- five times more ...
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Streptococcus mutans that cause tooth decay able to survive without important biochemical pathway
Scientists have long believed a certain biochemical pathway involved in the folding and delivery of proteins to cell membranes is essential for survival.
Now University of Florida researchers have discovered that Streptococcus mutans, the decay-causing organism that thrives in many a mouth, can do just fine without it.
The findings, reported in the Proceedings of the National Academy of Sciences, have rocked the cellular biology scientific community, which has long considered the pathway to be crucial.
The report may also explain why strains of the bacteria can survive in the harsh acidic environment they create in the mouth.
" We were met with skepticism … because the dogma was that this biochemical pathway is key for all living cells," said study investigator Jeannine Brady, at the UF College of Dentistry. "As far as we know, this is the first example of any bacteria that can cope without this pathway; all of the existing literature indicated it is vital."
The signal recognition particle, or SRP, pathway is a primary mechanism by which proteins are chaperoned from cellular assembly lines, where they are made, to the protective outer surface of the cells, where they are inserted. Without a steady infusion of proteins, the membrane weakens and the cell - in this case, a bacterium - becomes unable to protect itself from harsh environmental conditions.
In the human mouth, its natural environment, it is typically S. mutans that goes on the attack. When sugary foods are eaten, the S. mutans population explodes, excreting lactic acid as it digests sugar. The acid makes life difficult for other helpful bacteria and demineralizes tooth enamel, causing decay.
According to the U.S. Centers for Disease Control and Prevention, 95 percent of adult Americans suffer from tooth decay. Considered by the U.S. surgeon general to be a "silent epidemic," tooth decay is a chronic childhood disease that affects five times more children than asthma and is estimated to result in 51 million lost school hours.
In an effort to understand how best to combat the tooth-decaying properties of S. mutans, Brady and her team set out to learn how the organism was able to survive its own acid. To find out, the researchers tinkered with systematically turning off several genes, individually and in combination, to see how the bacteria responded.
" We found S. mutans can survive, with normal growth, without the SRP pathway," said Adnan Hasona, study's lead author.
The bacteria altered to lack SRP components were able to adapt and survive gradual increases in acid resulting from their own metabolism, suggesting a backup pathway was in place.
But the altered bacteria could not contend with sudden environmental change.
When artificially shocked with acid to a pH below that where tooth demineralization begins, the altered bacteria became sick and unable to grow.
Shocking the bacteria with other environmental stressors, such as high salt levels or the presence of hydrogen peroxide, also caused them to weaken, Hasona said.
"So, at least in this organism, we learned the SRP pathway seems to enable it to respond rapidly to environmental stress, but it was not at all necessary for the organism's viability during non-stress conditions," Brady said.
Brady's team surmised that two other molecules, called YidC1 and YidC2, might be acting as alternate routes for protein delivery in the absence of the SRP pathway. They tested their hypothesis and found that S. mutans could continue to function in non-stress conditions without the SRP and YidC1 genes, but not without the YidC2 and SRP simultaneously.
" The fact that the bacteria could survive without the SRP pathway was the most striking finding for scientists in the membrane protein insertion field," said Ross E. Dalbey, at The Ohio State University. "The big question now is discovering how these proteins are targeted in the absence of the SRP pathway, and I think that will be an important area of future research."
Dalbey said the YidC2 and the SRP pathway could become targets in fighting tooth decay because they have been shown to enable S. mutans to grow in acidic conditions. Additionally, the YidC molecule has been demonstrated to be important to bacterial virulence and growth and has the potential to become a target in fighting infectious diseases, he said.
