Protein arrests cervical cancer growth Australian Life Scientist, Australia - Nov 25, 2008 Bone morphogenetic protein-7 (BMP7) is a member of the transforming growth factor beta (TGF-beta) superfamily and normally plays a role in osteoblast ...
FibroGen Announces New Research on HIF-PHI and Anti-CTGF ... PipelineReview.com (press release), Spain - Nov 11, 2008 Bone morphogenetic protein-7 (BMP-7) is an important antifibrotic and proregenerative repair factor, which has been shown to prevent and reverse structural ...
Cholesterol-Lowering Drug Oneindia, India - Aug 4, 2008 A drug used to lower cholesterol and help prevent cardiovascular disease may help improve bone healing, shows a new animal model based study. ...
(#pharyngula on irc.synirc.net) ScienceBlogs - Jul 30, 2008 What the authors have done is to carefully dissolve away the mineral matrix of the bone, exposing delicate and still flexible scraps of tissue inside. ...
Another look at RPGs, this time from an isometric view GamingNexus, OH - Aug 6, 2008 But now, it looks as though Eschalon is going to exploit this bone dislocation made in my preconceived notions about isometric computer roleplaying games, ...
Modelling neurofibromatosis type 1 tibial dysplasia and its ... 7thSpace Interactive (press release), NY - Jul 31, 2008 Mice with conditionally inactivated neurofibromin (Nf1) in the developing limbs and cranium (Nf1Prx1) show bowing of the tibia caused by decreased bone...
What's New in Orthopaedic Research Journal of Bone and Joint Surgery (subscription) - Aug 1, 2008 Last year, that group reported the novel finding that osteocalcin, a bone-specific matrix protein, is an essential regulator of systemic energy homeostasis. ...
Influence Of Mesoscale Porosity On Cortical Bone Anisotropy ... Medical News Today (press release), UK - Jul 16, 2008 Cortical bone is a hard tissue constituting approximately 80% of skeletal mass and is conveniently described as a two-phase composite material: a soft phase ...
Normal maturational changes in bone matrix, mineral, and crystal size in the rat - JM Burnell, EJ Teubner, AG Miller - Calcified Tissue International, 1980 - Springer ... Percent OH-proline/ Mineral per bonematrix g/g mM/cm : I. 4 wk 85 -+ 8 10.03 0.350
0.209 1.04 9.83 1.89 2.45 58.1 0.502 (12) -+ 0.31 ? 0.018 + 0.009 -- 0.07 ...
Three quantitative ultrasound parameters reflect bone structure - CC Gluer, CY Wu, M Jergas, SA Goldstein, HK Genant - Calcified Tissue International, 1994 - Springer ... best by connec- tivity (rp = -0.33, P < 0.02), MILpERP (rp = -0.31, P < 0.03 ... such
as bone structure or the material properties of the bonematrix, might be ...
Subchondral bone in osteoarthritis - MD Grynpas, B Alpert, I Katz, I Lieberman, KPH … - Calcified Tissue International, 1991 - Springer ...bone particles (ie, mineral and matrix) by ultracentrifugation ... D. Grynpas et al.:
Subchondral Bone in Osteoarthritis ... 23.5 -+ 2.1 9.9 +- 1.0 0.31 ? 0.04 1.85 ...
Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats - CH Turner, Y Takano, I Owan, GA Murrell - American Journal of Physiology- Endocrinology And Metabolism, 1996 - Am Physiological Soc ... among treatment groups in any of the bone formation parameters (P > 0.31). ... and bone-lining cells sense mechanical signals within the bonematrix (29) and ...
Problems of bone analysis in childhood and adolescence - E Sch?nau - Pediatric Nephrology, 1998 - Springer ... 1,000 7 9 11 13 15 n = 14; r = 0.31 700 800 900 5 40 T otal bone area (mm 2 ) ... A marked
structural bonematrix disorder can be documented histologically. ...
Mechanisms of Action and Therapeutic Potential of Strontium in Bone - PJ Marie, P Ammann, G Boivin, C Rey - Calcified Tissue International, 2001 - Springer ... levels in man are between 0.11 and 0.31 mol/l ... Potential mechanisms of action of
strontium on bone cells. ... replication, leading to an increase of matrix synthesis ...
Human dentin-matrix-derived bone morphogenetic protein - K Bessho - Journal of Dental Research, 1991 - IADR ... similar to, bone-matrix-derived BMP, though both types of ... Studies have revealed that
BMP exists in the bonematrix (Sampath and Reddi, 1983; Muthukumaran et ...
Source: Google Scholar
Quality of bone matrix is regulated by TGF-beta
Researchers at University of California - San Francisco ( UCSF ) have determined that the quality of bone matrix, a key component of bone, is regulated by a molecule known as transforming growth factor beta.
The finding, they say, suggests a possible target for preventing and treating bone fractures associated with aging and genetic diseases.
The study is reported in the Proceedings of the National Academy of Sciences ( PNAS ).
The ability of bone to resist damage depends on the mass, or quantity, of bone, its architecture and the quality of bone matrix, the mineralized material between cells.
Several molecular factors have been shown to regulate the mass and architecture of bone.
So far, however, none have been shown to regulate bone matrix, which is responsible for bone elasticity and toughness.
In the study, the team explored whether transforming growth factor beta ( TGF-beta ) regulates the properties of bone matrix because there were hints that it might.
TGF-ß is known to play a role in the development of osteoblasts, cells that produce bone matrix.
The researchers carried out their evaluation in five sets of mice genetically engineered to produce differing levels of TGF-ß signaling within osteoblasts, and, for comparison, in normal, or 'wild type' mice.
After the animals had been euthanized, the team utilized highly sensitive instruments developed in the materials sciences -- atomic-force microscopy, x-ray tomography and micro-Raman spectroscopy -- to measure the properties of bone matrix independent of bone mass and architecture. They also compared the bones' resistance to fracture in a bending test.
The results were notable, according to Tamara Alliston at UCSF.
In animals genetically engineered to produce high levels of TGF-beta, the measurements of bone matrix indicated increased susceptibility to fracture. The matrix was less elastic, less hard and contained lower levels of the mineral calcium phosphate.
In addition, the animals' bones were less resistant to fracture in the bending test.
In contrast, in animals with low levels of TGF-beta the bone matrix was more elastic, harder, had higher mineral concentration and the bone overall had increased mass.
In addition, the bones were more resistant to fracture in the bending test.
The bones studied included the femur, tibia and calvarial parietal bones.
" This is the first evidence that properties of bone matrix can be regulated by a growth factor and that by modifying the TGF-beta pathway, specifically, these properties can be controlled," says Alliston.
The study suggests that TGF-beta could be targeted for clinical intervention in patients.
" By decreasing TGF-beta signaling at the relevant site in the body, we may be able to improve the quality of bone to either prevent the damage that occurs in osteoarthritis and osteoporosis, or improve the quality and speed of bone repair following bone fracture, joint implantation, dental implants or bone grafting.
Source: University of California - San Francisco, 2005
