Smiling through ... Calvin Muteesa The Sun, UK - Nov 21, 2008 BREAST CANCER: Breast and colon tumours in mice shrank three-fold when they were injected with the drug at Johns Hopkins University in the US. ...
India almond extracts show promise in diabetes, premature ... FreshPlaza, Netherlands - Nov 14, 2008 The estrous cycle comprises the recurring physiologic changes that are induced by reproductive hormones in most mammalian placental females. ...
Herceptin decision: Women let down Scoop.co.nz (press release), New Zealand - "Women with aggressive Her-2 breast cancer have been cruelly let down by the refusal of the Government's drug-buying agency to extend funding to 12 months ...
Breast cancer: What you need to know Food Consumer, IL - Aug 5, 2008 Eating French Fries May Raise Breast Cancer Risk. Weight loss: A study indicates that women with a mutation in the gene BRCA1, which predisposes women to ...
REGION: Nursing promoted during World Breastfeeding Week North County Times, CA - The department also says mothers who nurse lose their pregnancy weight faster and have a lower risk of breast or ovarian cancer. Haessly said the county's ...
Upcoming Events Culpeper Star Exponent, VA - October is Breast Cancer awareness month, which is why now through Oct. 31 you can donate $10 to be National Breast Cancer Foundation and receive a free ...
Growing Fat And Malaysian Today, Malaysia - ?It may sound shocking but obesity can also lead to cancer. It will mildly increase the risk for breast cancer and in the reproductive system. ...
Study Finds Vitamin C May Stop Cancer Growth NBC 10.com, PA - Aug 5, 2008 Tumor growth and weight was reduced by 41 to 53 percent and the brain cancer stopped spreading. "We've found it to be very helpful in cases of breast cancer...
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Journal Watch (General) 1997;1997:1-1. FULL TEXT. Weight...
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Prospective study of relative weight, height, and risk of breast cancer - SJ London, GA Colditz, MJ Stampfer, WC Willett, B … - JAMA, 1989 - Am Med Assoc ... Association of Body Composition and Weight History with BreastCancer Prognostic
Markers: Divergent Pattern for Hispanic and Non-Hispanic White Women ...
RELATIVE WEIGHT AND RISK OF BREAST CANCER AMONG PREMENOPAUSAL WOMEN - WC WILLETT, ML BROWNE, C BAIN, RJ LIPNICK, MJ … - American Journal of Epidemiology, 1985 - Oxford Univ Press ... the findings of these recent case-control studies could be replicated, we examined
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Cyclin E and Survival in Patients with Breast Cancer - K Keyomarsi, SL Tucker, TA Buchholz, M Callister, … - New England Journal of Medicine, 2002 - content.nejm.org ...breastcancer by five years after diagnosis, whereas all 12 patients with a high
level of low-molecular-weight cyclin E had died of breastcancer within that ...
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Higher placental weight associated with increased maternal breast cancer risk
A study, published in the Journal of American Medical Association, found that women with a higher placental weight in prior pregnancies have an increased risk of breast cancer, possibly from the hormones produced by the placenta.
Hormonal factors play a key role in the development of breast cancer.
Early menarche, late menopause, and long-term use of hormone therapy have been shown to be associated with increased risk of breast cancer.
Serum levels of estrogens, progesterone and placental growth hormones are many times higher during pregnancy than during other periods of life, and pregnant women also are exposed to elevated levels of insulin-like growth factors.
During pregnancy, these markers have been inconsistently associated with subsequent risk of breast cancer in the mother.
It has been hypothesized that placental weight could be an indirect measure of hormone exposure during pregnancy.
Sven Cnattingius, of Karolinska Institutet, Stockholm, Sweden, and colleagues investigated the possible associations between indirect markers of hormonal exposures during pregnancy, such as placental weight, offspring's birth weight, pregnancy complications, and subsequent maternal risk of developing breast cancer.
The researchers used data from the Swedish Birth Register, the Swedish Cancer Register, the Swedish Cause of Death Register, and the Swedish Register of Population and Population Changes. The study included women in the Sweden Birth Register who delivered single births between 1982 and 1989, with complete information on date of birth and gestational age.
Women were followed up until the occurrence of breast cancer, death, or end of follow-up ( December, 2001 ).
Of 314,019 women in the cohort, 2,216 ( 0.7 percent ) developed breast cancer during the follow-up through 2001, of whom 2,100 ( 95 percent ) were diagnosed before age 50 years.
The researchers found that compared with women who had placentas weighing less than 500 g in 2 consecutive pregnancies, the risk of breast cancer was increased among women whose placentas weighed between 500 and 699 g in their first pregnancy and at least 700 g in their second pregnancy ( or vice versa ), and the corresponding risk was doubled among women whose placentas weighed at least 700 g in both pregnancies.
A high birth weight ( 4000 g or greater ) in 2 successive births was associated with an increased risk of breast cancer before but not after adjusting for placental weight and other covariates. Compared with women who had a placental weight of less than 500 g, women who had a placental weight of at least 700 g had a 38 percent increase in risk of breast cancer.
" Our finding of a positive association between placental weight and breast cancer risk may reflect that exposures to elevated levels of pregnancy hormones influence the risk of breast cancer. The role of estrogens in breast carcinogenesis is well established, and serum estrogen levels are at least 10 times higher during pregnancy compared with other times of life," the authors write.
" In addition, placental weight appears to be a better indicator of the hormonal milieu than birth weight or other included birth parameters. Underlying biological mechanisms responsible for the observed associations may not only be limited to a direct growth enhancing effect on breast cells during childbearing, but also may be due to maternal characteristics or genetic factors associated with placental growth," the researchers conclude.
