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Recent News and Articles on the Keywords: drug + lupus + 501  Related to the article below (Last Update: 8/7/2008)

Support groups
Chambersburg Public Opinion, PA - Jul 24, 2008
Lupus, 7 pm, second Mondays, Classroom 1, Chambersburg Hospital, 112 N. Seventh St.; Kathleen Rollins, facilitator, 264-7099. Mother-to-Mother breastfeeding ...
Source: Google News

… -Sectional Analysis of the Differences Between Patients with Systemic Lupus Erythematosus in England … -
AE Johnson, FS Cavalcanti, C Gordon, O Nived, RG … - Lupus, 1994 - lup.sagepub.com
... 501 ... with Systemic Lupus Erythematosus in England, Brazil and ... Brazilian patients were
the most likely to be prescribed only one drug for treatment of SLE and to ...

Effect of FK-506, a novel immunosuppressive drug on murine systemic lupus erythematosus -
K Takabayashi, T Koike, K Kurasawa, R Matsumura, T … - Clinical Immunology and Immunopathology, 1989 - Elsevier
... This drug is also prescribed for patients with ... In: RG Lahita, Editor, Systemic Lupus
Erythematosus, Wiley ... Abstract | Full Text + Links | PDF (501 K) | View ...

Drug-Induced Lupus Erythematosus -
KD Pramatarov - Clinics in Dermatology, 1998 - Elsevier
Drug-Induced Lupus Erythematosus ... I prefer the term ?drug-induced lupus erythema-
tosus? (DILE), but there are no specific diagnostic criteria for DILE. ...

Drug-induced lupus erythematosus -
P Sarzi-Puttini, F Atzeni, F Capsoni, E Lubrano, A … - Autoimmunity, 2005 - ingentaconnect.com
Page 1. Drug-induced lupus erythematosus ... Keywords: Drug-induced lupus,
autoantibodies, autoimmunity, anti-histone antibodies Introduction ...

Subacute cutaneous lupus erythematosus arising in the setting of calcium channel blocker therapy -
AN Crowson, CM Magro - Human Pathology, 1997 - Elsevier
... Schaumberg-Lever G: Histopathology of the Skin (ed 7). Philadelphia, PA, Lippincott,
1990, pp 494-501 25. ... Yung IlL, Richardson BC: Drug-induced lupus. ...

Anti-histone antibodies in idiopathic and drug-induced lupus recognize distinct intrahistone regions -
JP Portanova - The Journal of Immunology, 1987 - Am Assoc Immnol
... ANTI-HISTONE ANTIBODIES IN IDIOPATHIC AND DRUG-INDUCED LUPUS RECOGNIZE DISTINCT
INTRAHISTONE REGIONS ... were common in drug-induced lupus. ...

Correlation of renal histology with outcome in children with lupus nephritis -
PJ Rush, R Baumal, A Shore, JW Balfe, M Schreiber - Kidney Int, 1986 - nature.com
... AD, Balow JE: Controlled studies of oral immunosuppressive drugs in lupus ... PJ, Lim
VS, Spargo BH, Katz AI: Lupus nephropathy without ... Medicine 56:493?501, 1977. ...

Serial assessment of glomerular filtration rate in lupus nephropathy -
M Petri, L Bockenstedt, J Colman, Q Whiting-O' … - Kidney Int, 1988 - nature.com
... JE: Controlled studies of oral immunosuppressive drugs in lupus ... V, Spargo B, Katz
A: Lupus nephropathy without ... Medicine 56:493?501, 1977; Rothfield NF: The ...

Metabolism of Hydralazine: Relevance to Drug-Induced Lupus -
AH Hofstra - Drug Metabolism Reviews, 1994 - informaworld.com
... that either the parent drug or a nonacetylated metabolite is involved in the lupus
syndrome. ... urine sample was collected from hydralazine-treated patients (501. ...

[BOOK] Dubois'Lupus Erythematosus -
DJ Wallace, EL Dubois - 2006 - books.google.com
... and, 500 splicing factors and, 501, 501/ viral proteins ... Gender; Hormones; Infertility;
Pregnancy, lupus disease flares ... on D1L, 872-874 in drug development, 1324 ...

Source: Google Scholar
 
 

Valproic acid, a common anti-seizure drug, could be effective for lupus

A animal research at Wake Forest University School of Medicine, found that a common anti-seizure drug may be effective against certain conditions associated with lupus.

The drug, Valproic acid ( Depakote ), prevents skin disease and reduces the severity of kidney disease in a mouse model of lupus, said Nilamadhab Mishra, at Wake Forest University Baptist Medical Center.

" Valproic acid may be a potential cost-effective disease-modifying agent in lupus," Mishra reported at the American College of Rheumatology meeting in San Diego.

And because the drug has been on the market since 1983, Mishra said that clinical trials to use Valproic acid for lupus could begin as early as next year.

" We already know the side effects," he said. That means that researchers can skip over the safety studies and move quickly to clinical trials to test its efficacy. While physicians could prescribe Valproic acid "off-label" to lupus patients, "it is better to have a clinical trial to prove that it does help in lupus," Mishra said.
 
Systemic lupus affects more than 1 million Americans, mostly women. About half of human patients with systemic lupus have kidney problems, but achy joints, skin lesions, frequent fever, arthritis and prolonged or extreme fatigue are far more common.

Mishra's team tested Valproic acid in a type of mouse that develops lupus that is similar to the lupus that occurs in people. None of the mice in the treatment group developed skin disease whereas all mice in the placebo group developed the disease, Mishra said.
The results were similar for kidney and diseases of the spleen.

For instance, the spleen ordinarily enlarges in lupus. The size of the spleen in the treatment group was nearly one-third less than the size in the control group.
 
In a second study, he showed that Mithramycin, an antibiotic usually used against tumors, also reduces kidney disease in experimental mice with lupus.

Excess protein in the urine – proteinuria – is a symptom of kidney disease, Mishra said.
In this study of mice born with lupus, only 33 percent of the mice getting Mithrmycin had excess protein in the urine at 16 weeks, compared to 50 percent of the mice that were not treated. By 19 weeks, the gap had widened, with just 22.2 percent of the Mithramycin group having excess protein, compared to 60 percent of the untreated group.

Other kidney function measures also showed a wide difference between the Mithramycin group and the control mice.
Renal vasculitis – inflammation of the tiny blood vessels in the kidney that can lead to kidney failure – occurred in 90 percent of the untreated mice, compared to 30 percent of the Mithramycin group.
 
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Mishra said that Mithramycin might have a beneficial effect in people with lupus. " Further studies are warranted," he said.

Mishra also described additional results from his ongoing research using a drug called TSA ( Trichostatin A ) on lupus. He described testing TSA on a second variety of mice that develop an autoimmune disorder similar to human systemic lupus.

In 2003, he had reported that in the same mouse model he used in the Valproic acid and Mithramycin studies, TSA led to a significant reduction in excess protein in the urine, inflammation of the kidneys, and spleen weight.

The new study, done in New Zealand Black and New Zealand White mice – which also develop an autoimmune disorder similar to lupus – had similar results.

Lupus is known as an autoimmune disorder because the body's own immune system turns on the rest of the body and attacks tissues and organs including the joints, kidneys, heart, lungs, brain and blood.

Source: Wake Forest University Baptist Medical Center, 2005

 

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