Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

Recent News and Articles on the Keywords: cbln1 + system + might  Related to the article below (Last Update: 12/1/2008)

 News results: Standard Version | Text Version | Image Version  
Browse Top Stories

Recent

Archives

Blogs

News Alerts News Alerts

RSS | Atom
About Feeds

Your search - cbln1 + system + might - did not match any documents.
Suggestions:
Make sure all words are spelled correctly.
Try different keywords.
Try more general keywords.
Try fewer keywords.
Try Google Blog Search.
Also, you can browse today's headlines on the Google News homepage.
Source: Google News

 

Recent News and Articles on the Keywords: web + 0.35  Related to the article below (Last Update: 8/7/2008)

Caliper Life Sciences Reports Second Quarter 2008 Results
FOXBusiness -
Our filings are available on a web site maintained by the Securities and Exchange Commission at http://www.sec.gov. Caliper does not undertake any ...CALP - OTC:CMTX
VeriSign Reports Second Quarter 2008 Results
CNNMoney.com -
A listen-only live web cast and accompanying slide presentation of the earnings conference call will also be available at http://investor.verisign.com. ...VRSN
FelCor Reports Second Quarter Operating Results
MarketWatch - Aug 5, 2008
Additional information can be found on the Company's Web site at www.felcor.com. We invite you to listen to our second quarter earnings Conference Call on ...FCH
Aug 7 - Open: Solid start for sharemarket
Stuff.co.nz, New Zealand -
The Dow Jones industrial average rose 0.35 percent to 11656.07, while the Standard & Poor's 500 Index gained 0.33 percent to 1289.18. ...
InfoSpace Announces Strong Second Quarter 2008 Results
Trading Markets (press release), CA - Aug 5, 2008
The live Webcast can be accessed in the Investor Relations section of the InfoSpace corporate Web site, at http://www.infospaceinc.com. ...INSP
Otelco Reports Second Quarter 2008 Results
Canada NewsWire (press release), Canada - Aug 5, 2008
To listen to the live call online, please visit the Web site at least 15 minutes early to register, download and install any necessary audio software. ...
Sun Healthcare Group, Inc. Reports Second Quarter Earnings ... Trading Markets (press release)
all 484 news articles »  SUNH - OTT - TSE:OTT.UN
Carpathian Gold Inc.: Drilling at the Ciresata Porphyry Cuts Best ...
MarketWatch - Aug 5, 2008
This hole intersected 262 m (from 162 m down hole) of 0.35 g/t Au and 0.10% Cu (0.56 g/t Au eq) and includes 35 m of 0.59 g/t Au and 0.15% Cu (0.91 g/t Au ...TSE:CPN - OTC:CMTX
j2 Global Reports Q2 2008 Results Revenues of $60.7 million; EPS ...
MarketWatch - Aug 5, 2008
The Company offers faxing and voicemail solutions, document management solutions, Web-initiated conference calling, and unified-messaging and communications ...JCOM - WAR:CFL
US market rises
Radio New Zealand, New Zealand -
The Dow Jones industrial average rose 40.30 points, or 0.35%, to 11656.07. Standard & Poor's 500 Index gained 4.30 points, or 0.33%, to 1289.18. ...
Altra Holdings Announces Record Financial Results for the Second ...
MarketWatch - Aug 4, 2008
Also, the company has posted slides on its web site at http://www.altramotion.com in the Investor Relations Section in the Events & Presentations tab to ...AIMC
Source: Google News

[PDF] The diameter of the world wide web -
R Albert, H Jeong, AL Barabasi - Arxiv preprint cond-mat/9907038, 1999 - arxiv.org
... shows, we find that the average of d over all pairs of vertices follows d =
0.35+2.06 log(N), indicating that the web forms a small-world network [5,7], known ...

… ecological and evolutionary interdependence between web architecture and web silk spun by orb web … -
CL Craig - Biological Journal of the Linnean Society, 1987 - Blackwell Synergy
... 2). The reference web radial pre-stress was set at 0.35 x lo9 N mP2 and spiral
pre-stress was set at approximately zero (0.35 x lo4 N m-*). All idealized webs ...

Exploring the factors associated with Web site success in the context of electronic commerce -
C Liu, KP Arnett - Information & Management, 2000 - Elsevier
... In order to further determine factors associated with Web site success, an exploratory
factor ... Some used the cut-off value of 0.35 [37], while others used the ...

[PS] Overview of the TREC-8 Web Track -
D Hawking, E Voorhees, N Craswell, P Bailey - Proc. of TREC-8 - research.microsoft.com
... isw50t .029 0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45 0.5 0 0.05 0.1 0.15
0.2 0.25 0.3 0.35 0.4 0.45 0.5 Small Web Ad Hoc Figure 3 ...
-

The detrital food web in a shortgrass prairie -
HW Hunt, DC Coleman, ER Ingham, RE Ingham, ET … - Biology and Fertility of Soils, 1987 - Springer
... Page 5. HW Hunt et al.: The detrital food web in a shortgrass prairie ...
Collembola 8 1.84 0.5 0.35 Predaceous mites 8 1.84 0.6 0.35 ...

Embedded configurable logic ASIC -
W Chang - US Patent 6,260,087, 2001 - freepatentsonline.com
... Inventors: Chang, Web; ... In the foreseeable future, ASIC geometry will decreases from
0.35 micron feature size to 0.25 micron, 0.18 micron or even smaller ...

Creating Adaptive Web Sites Through Usage-Based Clustering of URLs -
B Mobasher, R Cooley, J Srivastava - Proceedings of the 1999 Workshop on Knowledge and Data …, 1999 - doi.ieeecs.org
... In this paper we have presented an architecture for automatic Web personalization
based on Web usage data. ... personal-pages 0.37 /registration-info 0.35 ...

Comparing Web, Correspondence and Lecture versions of a second-year non-major Biology course -
M Collins - British Journal of Educational Technology, 2000 - Blackwell Synergy
... Web 22 74.7 125.39 11.20 t-tests t P Correspondence and lecture 1.584 0.05
Correspondence and Web 1.324 0.35 Lecture and Web 0.484 0.05 Page 4. ...

SILK MEDIATED DEFENSE BY AN ORB WEB SPIDER AGAINST PREDATORY MUD-DAUBER WASPS -
TA Blackledge, JW Wenzel - Behaviour, 2001 - Springer
... Spider responds to mimicry 0.21 0.42 Spider defensive behaviors Runs to edge of
web 0.35 0.39 Drops from web 0.47 0.47 Runs away from web 0.13 0.06 ...

Artifacts or Attributes? Effects of Resolution on the Little Rock Lake Food Web -
ND Martinez - Ecological Monographs, 1991 - JSTOR
... that 0.35 IjJ 0 0.3 Z <~ ~ 0.25 Z Z 0.2 O Lu 0.15 (,) 0.1 ~, o.o5 z -- 0 AM ~ TROPHIC
AXIMUM LINKAGE | SPECIES WEBS ~ WEB , "MINIMUM LINKAGE WEBS 0.35[ 0 50 ...

Source: Google Scholar
 
 

The lack of Cbln1 might contribute to nervous system diseases

Researchers at St. Jude Children's Research Hospital and colleagues in Hokkaido University School of Medicine ( Japan ) have found that the ability of the brain to transmit and process information requires a lifelong commitment to maintaining the integrity of synapses -- the special connections that permit the passage of nerve impulses from one nerve cell to another.

The report on this work is published in the Nature Neuroscience.

This long-term commitment requires proteins called synaptotrophins, the prototype of which is Cbln1, to maintain countless millions of synapses in good working order, the researchers said. In the absence of such proteins, the synapses weaken and eventually fall apart.
This not only compromises nerve transmission, but also provides the opportunity for other nerves to extend their axons toward these faltering synapses and make inappropriate connections that further disrupt brain function.

 
Traditionally, studies in this field emphasized the development of the nervous system, and focused on how axons navigate to the correct part of the brain and then recognize and make specific synaptic contacts with the correct type of nerve cells," said James I. Morgan, at St. Jude. " It now appears that there are other processes at work throughout adult life that maintain the integrity and function of these connections once they have formed."

The idea that synapses require maintenance factors in the adult is not new, although the identification of specific substances that contribute to this process has proven elusive, Morgan said. Therefore, the researchers used a laboratory model of the cerebellum to identify proteins that maintain a specific set of synaptic connections.
Using this model they found that Cbln1 maintains correct synaptic connections after they have been established.
 
The St. Jude team showed that Cbln1 maintains the connection between two types of nerves --Purkinje cells and granule cells.
Purkinje cells are large nerves that are aligned like dominos across the upper part of the cerebellum and send information to other parts of the brain.
Parallel fibers are the axons of granule cells and they form synapses with the dendrites of Purkinje cells.
The researchers showed that granule cells release Cbln1 from the ends of their axons -- the parallel fibers -- in order to maintain their synaptic connections with these dendrites.
Dendrites are threadlike branches on nerves that conduct incoming impulses from synapses to the body of the nerve cell.
 
Google
Web www.iconocast.com
When the investigators studied the electrical activity at the synapse between granule and Purkinje cells in models that lacked the gene for cbln1 ( cbln1-/- ), they found that the signals in Purkinje cells stimulated by granule cells were consistently smaller than normal.
In addition, the number of synapses between parallel fibers and Purkinje cells in cbln1-/- models was markedly reduced compared to cbln+/+ models. This was because the endings of the axons from granule cells (the presynapse) progressively detached from Purkinje cells.
However, the specialized regions of Purkinje cell dendrites that participate in the synapse ( postsynaptic spines ), were still present in normal numbers. But these unoccupied spines led to a second synaptic abnormality in the cbln1-/- model: the pattern of synapses between the Purkinje cells and another type of nerve, called the climbing fibers, was abnormal. Normally, only one climbing fiber makes a synapse with a particular Purkinje cell. But in the cbln1-/- models many climbing fibers had grown into the area of the cerebellum where Purkinje cells normally form these single synapses with parallel fibers; and these climbing fibers had established many synaptic contacts on each Purkinje cell at sites previously occupied by parallel fibers.

" Nerves are territorial and respond to signals that keep other types of nerves out of their area of the brain unless they have legitimate business there," Morgan said. " Without proteins like Cbln1 in the brain, some nerves extend their axons into neighboring territories, usurping abandoned postsynaptic sites and disrupting normal function."

The researchers also found that Cbnl1 plays a critical role in maintaining the molecular mechanisms that underlie long-term depression ( LTD ) at the parallel fiber-Purkinje cell synapse. LTD, an experience-dependent modification in the response of a nerve to stimulation, is viewed as a molecular form of memory. The molecular machinery that produces LTD is thought to be located in Purkinje cells. This suggests that Cbln1 released by granule cells must somehow influence LTD in Purkinje cells, Morgan said.

The authors propose this occurs through a protein in the postsynaptic spine ( dendrites ) of Purkinje cells called the orphan delta-2 glutamate receptor.
They note that models that lack delta-2 glutamate receptor in Purkinje cells are nearly identical to models that lack Cbln1 in granule cells. This suggest that delta-2 glutamate receptor somehow mediates the action of secreted Cbln1. As both delta-2 glutamate receptor and Cbln1 are members of larger families of proteins that have distinct patterns of expression throughout the brain, this type of interaction might provide a way to ensure that the correct synaptic contacts form between different sets of nerve cells.

" Our findings are a significant step in our goal of understanding how the brain maintains its synaptic integrity," Morgan said. " Moreover, these findings open the possibility that disruption of synaptotrophin function could play a role in the development of neurological and psychiatric disorders. Therefore, these proteins and the pathways through which they function might represent potential targets for therapeutic intervention in neurological and psychiatric diseases."

Source: St. Jude Children's Research Hospital, 2005

 

Continue News With: News2 ; News3 ; News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 © 2002-2006

Keywords::

Contact Iconocast

Home Page