Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California


Recent News and Articles on the Keywords: neuroblastoma + gene + caspase  Related to the article below (Last Update: 12/1/2008)

 News results: Standard Version | Text Version | Image Version  
Your search - neuroblastoma + gene + caspase - did not match any documents.
Suggestions:
Make sure all words are spelled correctly.
Try different keywords.
Try more general keywords.
Try fewer keywords.
Try Google Blog Search.
Also, you can browse today's headlines on the Google News homepage.
Source: Google News


 

Recent News and Articles on the Keywords: 0.36 + web + neuroblastoma  Related to the article below (Last Update: 8/7/2008)

Salem Communications Announces Second Quarter 2008 Total Revenue ...
MarketWatch -
... net of tax $ - $ 0.03 $ - $ 0.09 Basic income per share after discontinued operations $ 0.12 $ 0.15 $ 0.25 $ 0.36 Diluted income per share before ...SALM
2009 Chevrolet Traverse is the Most Aerodynamic Lambda
Automobile Magazine -
According to the General, Buick's Enclave and Saturn's Outlook each has a higher drag coefficient of 0.36, while the GMC Acadia's 0.34 drag coefficient is ...
Ashford Hospitality Trust Reports Second Quarter Results
MarketWatch -
Additional information can be found on the Company's web site at www.ahtreit.com. Certain statements and assumptions in this press release contain or are ...AHT
Alliant Energy Announces Second Quarter 2008 Results
PR Newswire (press release), NY - Aug 6, 2008
An archive of the webcast will be available on the Company's Web site at http://www.alliantenergy.com/investors for 12 months. Alliant Energy is the parent ...LNT - KIDS
Amkor Reports Second Quarter 2008 Results
MarketWatch - Aug 5, 2008
This call is being webcast by Thomson Financial and can be accessed at Amkor's web site at www.amkor.com. You may also access the call by dialing ...AMKR
Pre-Market: Market likely to remain rangebound
Myiris.com, India -
China`s Shanghai Composite rose 9.82 points, or 0.36%, to trade at 2729.19. South Korea`s Kospi index dropped 12.87 points, or 0.82%, to trade at 1565.84. ...
Gerdau SA Announces 1st Half 2008 Results
CNW Telbec (Communiqu?s de presse), Canada -
Metalurgica Gerdau SA shareholders will receive R$ 0.60 per share and Gerdau SA shareholders R$ 0.36 per share. -- EBITDA reaches R$ 4.7 billion in the 1st ...GGB - SAO:GOAU4
Cisco Reports Fourth Quarter and Fiscal Year 2008 Earnings
CNNMoney.com - Aug 5, 2008
We believe we are entering the next phase of the Internet as growth and productivity will center on collaboration enabled by networked Web 2.0 technologies. ...
Covidien Reports Third-Quarter 2008 Results MarketWatch
all 454 news articles »  CSCO
National Retail Properties, Inc. Q2 2008 Earnings Call Transcript
Seeking Alpha, NY - Aug 4, 2008
These stores are generally smaller units, and in total they represent about 0.36% of our current annual base rent. Our guidance does take into affect the ...NNN
Nexstar Broadcasting Group Reports Record Second Quarter Results
Trading Markets (press release), CA - Aug 5, 2008
A live audio webcast of the call will be accessible to the public on Nexstar's web site, www.nexstar.tv. A recording of the webcast will subsequently be ...
W&T Offshore Reports Record Second Quarter Earnings Per Share of ... PR Newswire (press release)
all 484 news articles »  WTI - NXST
Source: Google News

… -5 by micro RNA interference affects proliferation, apoptosis and differentiation of neuroblastoma -
B Tanno, V Cesi, R Vitali, F Sesti, ML Giuffrida, … - Cell Death and Differentiation, 2005 - nature.com
... 22, 23 Neuroblastoma (NB), a childhood tumor originating from the embryonic neural
crest, is IGF2 ... from a maximum of 52.63 0.31 to a minimum of 23.91 0.36 ng/10 ...

Transthyretin inhibition of amyloid beta aggregation and toxicity -
S Giunta, MB Valli, R Galeazzi, P Fattoretti, EH … - Clinical Biochemistry, 2005 - Elsevier
... 2). Both the low ?CSF-like?, 20 ?g/mL (0.36 ?M), and ... (C) SK-N-BE neuroblastoma cells
treated ... figure legend, the reader is referred to the web version of ...

Data management and statistical methods used in the analysis of balanced chromosome abnormalities in … -
T Karrison, KJ Archer, R Espinosa, M Wen, D Huo - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... data over the World Wide Web (Appendix A ... lung carcinoma, melanoma, mucoepidermoid
tumor, neuroblastoma, ovarian carcinoma ... 2002), the odds ratio of 0.36 in column ...

[BOOK] Fundamentals of Biostatistics -
B Rosner - 2006 - books.google.com
... of the pancreas: Problems 1 0.35-1 0.36, 450 arsenic ... neuroblastoma screening in young
children: Problems 7.91 -7.93, 292 ... com i5 the World Wide Web site for ...

[PDF] Apoptosis of human malignant glioma-derived cell cultures treated with clomipramine hydrochloride, …
KA Parker, GJ Pilkington - onko-i.si
... 2116, E-mail: Geoff.Pilkington@port.ac.uk, Web- site: www ... 100?M 6h 11.03 49.16 3.91
10.97 10.73 0.36 ... C6 glioma cells (25 ?M ) and human neuroblastoma SH-SY5Y ...

[PDF] Dielectrophoretic Cell Separation and Gene Expression Profiling on Microelectronic Chip Arrays -
Y Huang, S Joo, M Duhon, M Heller, B Wallace, X Xu - Biochim. Biophys. Acta, 1997 - ece-classweb.ucsd.edu
... cells (Ind-2) from PBMC, as well as separation of neuroblastoma cells (SH ...
10.1021/ac011273v CCC: $22.00 ? 2002 American Chemical Society Published on Web ...
-

Norcantharidin analogues Synthesis and evaluation of growth inhibition in a panel of selected tumor- …
L Deng, L Shen, J Zhang, B Yang, Q He, Y Hu - Canadian Journal of Chemistry, 2007 - ingentaconnect.com
... producing IC 50 values from 0.36 ?mol/L ... mucoepidermoid carcinoma, adenocystic carcinoma,
neuroblastoma, bone, leukaemia ... on the NRC Research Press Web site at ...

Anti-Cancer/Anti-Tumor
N Opacic, M Barbaric, B Zorc, M Cetina, A Nagl, D … - Journal of Medicinal Chemistry - ingentaconnect.com
... Web URL: http://pubs.acs.org/journals/jmcmar/ 1. The novel L - and D -amino acid
derivatives of hydroxyurea and hydantoins: Synthesis, X- ray crystal structure ...

Effect of co-administration of retinoids on rat embryo development in vitro -
HE Ritchie, PD Brown-Woodman, A Korabelnikoff - Birth Defects Research Part A Clinical and Molecular …, 2003 - doi.wiley.com
... work had demonstrated that the visceral arches were targets for 13cRA and tRA
dysmorphogenesis (Web- ster et ... Control 0 67 92.7 91.2 23.8 1.60 2.89 0.36 100 0 0 ...

Photoreactivity of indirubin derivatives -
D Olivier, MA Poincelot, S Douillard, C Lefevre, J … - Photochemical & Photobiological Sciences, 2008 - rsc.org
... First published on the web 22nd January 2008. ... SH-SY5Y human neuroblastoma cell line
was grown in DMEM ... MLS 2044, 482.90, 519, 0.31, 519, 0.36 (116.13%), 0.30 (83.66 ...
-

Source: Google Scholar
 
 

Caspase-8 gene plays a critical role in suppressing metastasis of neuroblastoma

The caspase-8 gene plays a critical role in suppressing metastasis of neuroblastoma, and the expression of this gene is frequently absent in cancer cells that are aggressively metastasising.

Neuroblastoma is a tumor of the nervous system and is the most common tumor in infants younger than 1 year of age; it accounts for 7-10 percent of childhood cancers.

In the absence of caspase-8 protein, the cell is significantly more capable of escaping from the primary tumor and spreading to other sites in the body.
The investigators, at St. Jude Children's Research Hospital and the University of California at San Diego ( UCSD ), also showed in laboratory studies that restoring the expression of the caspase-8 gene suppressed neuroblastoma metastases.

The findings are significant because they suggest that novel treatments that restore the tumor-suppression role of the caspase-8 gene might prevent the spread of neuroblastoma and improve patient outcome, according to Jill M. Lahti.

 
Caspase-8 triggers apoptosis by binding to molecules called integrins that project from the surface of cells, including neuroblastoma cells.
Normally, integrin molecules anchor the cell to the extracellular matrix--the material outside the cell consisting of gel and fibers that support and provide structure to tissues.
When cells become dislodged from the extracellular matrix, as happens during metastasis, the unbound integrin molecules are free to bind with caspase-8, Jill M. Lahti said.
The binding of caspase-8 to integrin then triggers integrin-mediated death ( IMD ), a form of apoptosis.
 
Cells aren't usually supposed to break away from their location in the body, so the IMD response disposes of wayward cells before they can cause trouble," Lahti explained. " We showed that neuroblastoma metastasis is especially potent in the absence of caspase-8."

To investigate the impact of the loss of caspase-8 and/or integrins on neuroblastoma metastasis, the team tested the ability of tumor cells removed from patients for their ability to metastasize in laboratory embryo models. When the team blocked expression of the caspase-8 gene in neuroblastoma cells implanted in these models, the cancer cells broke away more readily from the tumor and spread with higher frequencies to the lung and bone marrow.
 
Google
Web www.iconocast.com
When the team implanted human neuroblastoma cells into other adult laboratory models, they generated metastases to the ovary, adrenal glands, kidneys and liver. These metastases have lost expression and activity of caspase-8.
These findings suggest that the loss of caspase-8 expression promotes metastases of neuroblastoma cells, the researchers reported.

Although the presence or absence of caspase-8 did not appear to affect the growth of the primary tumor, the researches discovered that significantly more cells outside the tumor underwent apoptosis when the gene was present; and significantly fewer underwent apoptosis went the gene was absent. The team made a similar finding in human patients whose neuroblastoma had spread from the primary tumor.

Source: St. Jude Children's Research Hospital, 2006

 

Continue News With: News2 ; News3 ; News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 © 2002-2006

Keywords::

Contact Iconocast

Home Page