Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome... MarketWatch - Nov 13, 2008 "We are eager to test the compound in patients with carcinoid syndrome who suffer from significant gastrointestinal symptoms relating to the overproduction ...
Is rett syndrome an ASD? Examiner.com - Nov 14, 2008 In a study in 2007 led by Dr. Adrian Bird at Edinburgh University, the affects of rett syndrome were reversed in a mouse that was bred to have symptoms...
Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome... PharmaLive.com (press release), PA - Nov 13, 2008 "We are eagerto test the compound in patients with carcinoid syndrome who sufferfrom significant gastrointestinal symptoms relating to theoverproduction of ...LXRX
UPDATE 1-Merck drug fails to slow Alzheimer's symptoms Reuters - Nov 17, 2008 Sevigny said Merck proceeded with the study in large part because the drug worked in mice with a form of Alzheimer's disease, but the mouse model may not be ...MRK
New mouse model for study of Creutzfeldt-Jakob disease Cordis News, Belgium - Nov 27, 2008 The result was an animal that exhibited similar symptoms to human CJD patients. The animals, called Tg(CJD) mice, show memory impairment and ...
Bone formation goes with the gut, study finds EurekAlert (press release), DC - Nov 26, 2008 "From the beginning it was a human story that we've now worked out in the mouse." The findings suggest that OPPG and high bone mass syndrome are actually ...
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Caliper Life Sciences Reports Second Quarter 2008 Results PharmaLive.com (press release), PA - To access a telephone playback of the proceedings from August 6 through August 13, dial 888-286-8010 and use the participant passcode of 48521551. ...CALP
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BDNF alleviates disease symptoms in a mouse model of Rett Syndrome
Researchers from the Whitehead Institute for Biomedical Research, Brandeis University and Massachusetts Institute of Technology report in the journal Neuron that increasing levels of brain derived neurotrophic factor ( BDNF ) alleviates symptoms in a mouse model of the childhood disorder Rett Syndrome.
Rett Syndrome ( RTT ) is a severe neurological disorder diagnosed almost exclusively in girls. Children with RTT appear to develop normally until 6 to 18 months of age, when they enter a period of regression, losing speech and motor skills. Most develop repetitive hand movements, irregular breathing patterns, seizures and extreme motor control problems. RTT leaves its victims profoundly disabled, requiring maximum assistance with every aspect of daily living. There is no cure.
In late 2003 Rudolf Jaenisch of the Whitehead Institute and Michael Greenberg of Children's Hospital Boston announced that the " Rett Syndrome gene ", Mecp2, interacts with bdnf. Interestingly, BDNF is highly active in infants aged 6 to 18 months, the same age that RTT symptoms first appear. BDNF is essential for neural plasticity, learning and memory. BDNF is also implicated in other neurological disorders including Huntington's Disease, schizophrenia and depression.
The bdnf/Mecp2 discovery, which was done in vitro, raised the question of whether BDNF levels contribute to the devastating symptoms seen in RTT. To investigate the in vivo role of BDNF in RTT Qiang Chang, a researcher in the Jaenisch lab, manipulated BDNF levels in the brains of genetically engineered "Rett mice". He discovered that deleting bdnf from the Mecp2 mutant mice resulted in an earlier onset and accelerated disease progression while increasing levels of BDNF led to a later onset and slower disease progression. In fact the mice were far less lethargic, had slightly larger brains and longer lifespans.
" This is the first instance that the Rett disease progression has been altered by changing expression of another gene. Once we understand the molecular mechanism of BDNF's effect on Rett mice it may be possible in the future to design rational therapies that could alter the disease progression in patients," said Rudolf Jaenisch.
" The next step is to understand how much BDNF overexpression is needed and in which specific parts of the brain," states Qiang Chang.
