Acupuncturist pinpoints health issues, restores body's balance Memphis Commercial Appeal, TN - Nov 9, 2008 Ly treats Sammi Jo for eosinophilic esophagitis, or EE, a disorder of the esophagus she's had since she was a baby. It can cause severe digestive problems. ...
Source: Google News
Recent News and Articles on the Keywords: eosinophilic + 2,260 + 0.52 Related to the article below (Last Update: 8/7/2008)
Disorder makes eating nearly impossible for boy Chicago Tribune, United States - Aug 4, 2008 Christopher hasn't eaten a conventional meal since Oct. 22, 2007, because he suffers from Eosinophilic esophagitis (EE) disease, a rare, incurable disorder ...
Medical ELeft untreated, blood disorder can cause tissue damage Post-Bulletin, MN - Aug 4, 2008 This condition is chronic eosinophilic leukemia, rather than HES. The good news for these patients is that nearly all respond to the drug imatinib mesylate. ...
APFED Announces Approval of ICD9 Codes for Eosinophilic... PR-CANADA.net (press release), Montenegro - Jul 19, 2008 APFED announced today that ICD-9-CM codes have been approved for Eosinophilic Gastrointestinal Disorders, EGID, by the National Counsel for Health ...
String probes for devastating childhood digestive disease EurekAlert (press release), DC - Jul 30, 2008 The two other grants are from the American Gastroenterological Association (AGA) and the CURED Foundation (Campaign Urging Research for Eosinophilic...
England boss Cap lifts Paul The Sun, UK - Aug 3, 2008 Paul ? who lives in Grimsby, Lincs, with mum Kelly, 32 ? is the only Brit diagnosed with eosinophilic gastroenteropathy.
Boy battles disease that makes foods, even smells, harmful Meriden Record-Journal, CT - Jul 31, 2008 Timmy suffers from an eosinophilic gastrointestinal disease which has no cure. Individuals, most of whom are children, contract the disease because of an ...
Allergic to life The Sun, UK - Jul 17, 2008 His condition, eosinophilic gastroenteropathy, is so rare that Paul is the first Brit to be diagnosed with it since the 1920s. Football-loving Paul can ...
Endotoxins prevent murine IgE production, TH2 immune responses, and development of airway … - K Gerhold, K Bl?mchen, A Bock, C Seib, P Stock, T … - The Journal of Allergy and Clinical Immunology, 2002 - Elsevier ... of LPS on allergen sensitization and eosinophilic airway inflammation ... n = 12)2371 ?
865? 6138 ? 2260? 0.08 ? 0.01*,? 1.98 ? 0.52?,? 0.42 ? 0.09 ...
Immunoglobulin (Ig) E Expression Pattern in Lung: Relation to Systemic IgE and Asthma Phenotypes - S Balzar, M Strand, D Rhodes, SE Wenzel - The Journal of allergy and clinical immunology, 2007 - pubmedcentral.nih.gov ... 412-692-2244; Fax 412 692-2260 E-mail ... with eosinophilic (SAeo + ) and non-eosinophilic
(SAeo - ) severe ... with eosinophils and lymphocytes (r s =0.52; p<0.0001 ...
- DJ Smith, M Jalkanen, F Flp, L Lzr, Z Szakonyi, G … - US Patent 6,624,202, 2003 - Google Patents ... Exp. Med. 178:2255-2260, Rockefeller University Press (1993). ... 178:2255-2260
(1993): Arvillorm, A., el a\, Eur. J Immunol. ,, . , jMed. ...
Neurodegeneration and Neuroprotection in Parkinson Disease - S Fahn, D Sulzer - NeuroRX, 2004 - Elsevier ... neurons. In PD, intracytoplasmic eosinophilic inclusions called Lewy bodies
are usually present in many of the surviving neurons. ...
- MR Hamblin, J Khadem - US Patent 7,077,839, 2006 - Google Patents Page 1. (12) United States Patent Hamblin et al. (22) Filed: Jun. 16, 2003
(65) Prior Publication Data US 2003/0216718 Al Nov. 20, 2003 ... -
[CITATION] 267 Vasopressin: Action in WRK-1 rat mammary tumor cells 271 Cholangiocellular carcinomas induced in … RC Warrington, WD Fang, F Kanzawa, M Maeda, T … - JNCI, Journal of the National Cancer Institute, 1978 - National Cancer Institute -
[CITATION] Effects of feeding regimes and diet temperature cycles on otolith increment formation juvenile … JD Neilson, GH Geen - Fishery Bulletin of the Fish and Wildlife Service, 1971 - The Service, US Govt Print. Off
[CITATION] 198 Announcements G Malignancies - JNCI, Journal of the National Cancer Institute, 1978 - National Cancer Institute -
[CITATION] Meeting Highlights E Matrix - JNCI, Journal of the National Cancer Institute, 1978 - National Cancer Institute -
Source: Google Scholar
Genetic profile of eosinophilic esophagitis discovered
A disease that was often misdiagnosed in the past, eosinophilic esophagitis has been increasingly recognized in the United States, Europe, Canada and Japan in the last few years.
Cases of the disease can be devastating since children who suffer from it may have a host of lifelong problems.
Now, an interdisciplinary team of researchers has published a major advance in understanding eosinophilic esophagitis .
In the Clinical Investigation, the team reveals that a highly specific subset of human genes plays a role in this complicated disease.
" Understanding the genetic profile of a disease such as eosinophilic esophagitis is an important first step towards developing new ways to diagnose and treat it," says NIAID Director Anthony S. Fauci.
In eosinophilic esophagitis, the esophagus becomes inflamed -- often, but not always, due to allergic reactions to food. This inflammation causes nausea, heartburn, vomiting and difficulty swallowing. In advanced cases, children may suffer from malnutrition, often require special liquid diets, and may need to have a feeding tube inserted in order to receive nourishment.
Eosinophilic esophagitis, first identified in 1977, has been increasingly recognized since the advent of diagnostic endoscopy, a procedure in which a flexible fiber-optic tube is inserted down the throat to directly image and biopsy the esophagus.
Historically, part of the reason why the disease has been misdiagnosed is that its symptoms are very similar to those of acid reflux disease. However similar the two diseases are in terms of symptoms, their underlying physiology is vastly different. Drugs on the market for treating acid reflux do not abate the symptoms of eosinophilic esophagitis, which is not caused by production of stomach acid, but likely by inflammation in the esophagus resulting from the abnormal accumulation of immune cells know as eosinophils--hence its name eosinophilic esophagitis. Eosinophils are white blood cells that contain inflammatory chemicals, highly reactive proteins, destructive enzymes, toxins, muscle contractors and signaling molecules that can guide immune defenses to the site of infection.
At the Cincinnati Children's Hospital Medical Center, Marc E. Rothenberg, has seen patients with eosinophilic esophagitis for a number of years and pursued clinical and laboratory research on the disease as well. To better understand the disease, Rothenberg and his colleagues examined the gene expression in tissue samples taken directly from the esophagus of individuals with eosinophilic esophagitis as well as from people without the disease. These individuals were selected to represent a diverse sample with respect to age, sex and disease state. Rothenberg and his colleagues found that a particular set of 574 genes were expressed differently in people with eosinophilic esophagitis from people without the illness.
This transcript signature, as they call it, yielded some surprising findings; it was largely the same for every person with eosinophilic esophagitis, regardless of age and whether or not these people had food allergies.
This transcript signature was quite distinct from the signature observed in patients with acid reflux disease, thus allowing the two diseases to be easily discriminated.
Although eosinophilic esophagitis is more common in males than in females, the genes expressed in the esophagus did not vary dramatically between males and females with eosinophilic esophagitis. Of the 574 genes, the investigators found that the expression of one gene in particular, termed eotaxin-3, was elevated in people with eosinophilic esophagitis compared to people without the disease--at up to more than 100-fold greater amounts in eosinophilic esophagitis than controls.
Eotaxin-3, a factor released from certain cells and tissues, acts to attract circulating eosinophils, yet no one had previously observed that the local levels of eotaxin-3 correlated directly with the number of eosinophils in the esophagus.
In their paper, Rothenberg and his colleagues also demonstrated that, in a mouse model of eosinophilic esophagitis, mice lacking receptors for eotaxin were protected against developing eosinophilic esophagitis.
These results, when taken with those of the human studies, suggest that a drug to block eotaxin-3 might have therapeutic value.
Finally, by sequencing the eotaxin-3 genes of all the people in their study, the investigators identified certain genetic variations known as single nucleotide polymorphisms ( SNPs ) -- particular spots within the DNA sequence of the gene where a single base of DNA may vary from person to person. One particular SNP in the gene appears to occur more frequently in patients with eosinophilic esophagitis than in controls, and, if this is confirmed, SNPs may provide a way to determine if people are at risk for eosinophilic esophagitis.
