? Scientists Link Fast Food to Alzheimer's Consumer Affairs - Akterin and colleagues are taking a different tack, focusing on genetic features of some people that may make them more vulnerable to the disease. ...
Study links asthma rate to birth month Boston Globe, United States - The same is true of Alzheimer's patients, adults with brain tumors, and children with congenital valvular heart disease. So does it make sense for parents ...
Study Recruiting From Alzheimer's-Prone Families Washington Post, United States - Nov 28, 2008 28 (HealthDay News) -- The adult children of people with the rarer, inherited form of Alzheimer's disease are being sought for a new study to better ...
Myriad Genetics: Profits In Predictive Medicine istockAnalyst.com (press release), OR - ... but prediction may be even more valuable as we develop new treatments to prevent the onset of diseases like cancer and Alzheimer?s disease. ...MYGN
This Week in Health Intelihealth.com, PA - Nov 21, 2008 This week we learn that ginkgo supplements don't prevent dementia and Alzheimer's disease, that family history is a good indicator of breast cancer risk, ... This Week in JAMAJournal of American Medical Association (subscription) all 559 news articles »
Internet searching stimulates brain, study says San Francisco Chronicle, USA - Nov 29, 2008 It's too early to conclude that technology will help vanquish Alzheimer's disease, but "our study shows that when your brain is on Google, ...
As the Worm Turns: Discovering of a Life of Discovery Washington and Lee University News Office, VA - In fact, as more of this molecular stuttering occurs in the genetic code of our cells, the sooner the time we will succumb to the disease (Ridley, 2000). ...
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Recent News and Articles on the Keywords: alzheimers + disease + development Related to the article below (Last Update: 8/7/2008)
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Race for a cure for Alzheimer's The Republican - MassLive.com, MA - Aug 6, 2008 If you had a genetic marker that increased your risk of Alzheimer's disease would you want to know? Dr. Francis S. Collins, the outgoing director of the ...
Vitamin B12 and folate in relation to the development of Alzheimer's disease - HX Wang, A Wahlin, H Basun, J Fastbom, B Winblad, … - Neurology, 2001 - AAN Enterprises ... Wahlin, H. Basun, J. Fastbom, B. Winblad, and L. Fratiglioni Vitamin B12 and folate
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… of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. - M Goedert, R Jakes, RA Crowther, J Six, U L?bke, … - Proceedings of the National Academy of Sciences of the …, 1993 - pubmedcentral.nih.gov ... Copyright notice. The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. ...
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Genetic factors important in development and timing of Alzheimer's disease
A large study of twins, published in the Archives of General Psychiatry, found that Alzheimer's disease appears to be highly heritable and genetic factors may also influence timing of the disease.
Two-thirds of adults aged 65 years and older with dementia have Alzheimer's disease, and the number of Alzheimer's disease cases is predicted to increase with the growing older adult population.
Although genetic risk factors for Alzheimer's disease have been identified, only a fraction of Alzheimer's disease cases can be explained by specific gene mutations.
Studies of twins have been helpful in investigating the relative importance of genetic and environmental influences in disease development. For example, if monozygotic twins do not both have a disease, environmental factors may be implicated for its occurrence.
Margaret Gatz, at the University of Southern California, Los Angeles, and colleagues evaluated 11,884 pairs of twins from the Swedish Twin Registry to examine the association between genetic and environmental influences and Alzheimer's disease.
The study included patients from the registry who tested positive for dementia and their twins, plus a sample of twins without dementia.
The researchers identified 392 pairs of twins in which one or both had Alzheimer's disease.
The researchers estimated heritability for Alzheimer's disease to be between 58 and 79 percent. Among pairs where both twins had Alzheimer's disease, there was an average of 3.66 years difference in age at onset between 25 sets of identical twins, and 8.12 years difference between 20 sets of dizygotic twins.
This lead the researchers to conclude that genes had a role in disease timing "…because age at onset of Alzheimer's disease is significantly more similar for concordant monozygotic pairs compared with concordant dizygotic pairs." Concordance rates were higher in women, reflecting their greater longevity.
" In the largest twin study to date, we confirmed that heritability for Alzheimer's disease is high and that the same genetic factors are influential for both men and women," the authors write. " However, nongenetic risk factors also play an important role and might be the focus for interventions to reduce disease risk or delay disease onset."
