A New Option for Migraine Treatment on the Horizon HealthNews, CA - Nov 27, 2008 Migraines are commonly treated with drugs known as triptans like zolmitriptan (zomig). However, the use of these medications carries the risk of side ...
Recent News and Articles on the Keywords: migraine + triptan + 0.37 Related to the article below (Last Update: 8/7/2008)
Health Alert: Migraine insurance WIS, SC - Jul 15, 2008 "I find that after I have my migraines, it's almost like it just tires you out." Sandy is supposed to take Triptan medication when she feels a migraine...
Sudden impact South China Morning Post (subscription), Hong Kong - Jul 20, 2008 But if a simple painkiller isn't effective, once the migraine has kicked in you can try a triptan drug. It replaces the hormone serotonin - which dips ...
Migraine Study Shows Merck's Telcagepant Promising ClinicalTrialsToday, MA - Jul 14, 2008 "Based on this initial large study, the investigational compound telcagepant relieved migraine pain and migraine associated symptoms comparable to a triptan...
الشقيقة... هل نتخلّص منه يوماً؟ الجريدة, Kuwait - Jul 14, 2008 في الحالات الأكثر تعقيداً، يُنصح بتناول أدوية التريبتان (triptan)، ولعل أبرزها دواء سوماتريبتان (Sumatriptan). لكن هذه الأدوية لا تُباع إلا بموجب وصفة طبيب، ...
Almotriptan Versus Rizatriptan in Patients With Migraine in Spain - R Leira, E Dualde, H del Barrio, M Machuca, A … - Headache: The Journal of Head and Face Pain, 2003 - Blackwell Synergy ... The average number of migraine attacks per patient was ... was also lower for rizatriptan
(0.37 tablets, [SD ... medication were associated with lower triptan use of ...
CGRP may play a causative role in migraine - LH Lassen, PA Haderslev, VB Jacobsen, HK Iversen, … - Cephalalgia, 2002 - Blackwell Synergy ... when they were treated with placebo (P = 0.37, manova ... direct participation of CGRP
in migraine mechanisms ... Although the triptans represent a major step forward in ...
MECHANISM OF MIGRAINE AND ACTION OF ANTIMIGRAINE MEDICATIONS* - ELH Spierings - Medical Clinics of North America, 2001 - Elsevier ... n = 34), after administration of ergotamine, 0.37 to 0.5 ... Effect of oral triptans,
1.5 to 2.5 hours ... temporal artery, in millimeters, between migraine (n = 16). ...
Almotriptan Versus Rizatriptan in Patients With Migraine in Spain M Machuca, PD PharmD, A Lopez-Gil? - Headache, 2003 - ingentaconnect.com ... attacks, the use of additional nontriptan drugs was also lower for rizatriptan
(0.37 tablets, [SD, 0.71 ... COMMENTS Triptan tablet use per migraine attack over ... -
Adding trimebutine to rizatriptan therapy appears to hasten the resolution of migraine attacks, according to a study.
Trimebutine is "well-tolerated" and "may represent an additional resource in the available arsenal to treat migraine attacks," investigators say.
"In an era of potential new agents for the acute treatment of migraine, raising the efficacy of already safe and available drugs through the combination of traditional medications may represent an attractive option," they write in a report in the journal Cephalagia.
Delayed gastric emptying, or "gastric paralysis," is common during migraine attacks and can delay the onset of action for drugs taken by mouth, Dr. Abouch V. Krymchantowski, from Hospital Pasteur in Rio de Janeiro, Brazil, and colleagues explain.
This is particularly relevant for triptans, which seem to work best during the early stages of an attack.
Therefore, use of a "gastrokinetic" agent, such as trimebutine that helps regulate movement of contents in the gastrointestinal tract, could potentially improve the efficacy of triptan therapy. Trimebutine is often used to treat irritable bowel syndrome (spastic colon).
In a crossover study, the investigators assessed the outcomes of 40 patients who were randomized to treat two consecutive migraine attacks with rizatriptan (10 mg) plus either trimebutine (200 mg) or placebo.
A total of 64 attacks were treated with each of the regimens.
Within 1 hour of dosing, 30 (46.8 percent) of the attacks treated with the two-drug combination had resolved compared with just 8 (12.5 percent) of the attacks treated with rizatriptan alone, a significant difference. At 2 hours, the difference persisted with corresponding resolution rates of 73.4 percent and 31.2 percent.
Rizatriptan plus trimebutine was also significantly better than rizatriptan alone at resolving the nausea and photophobia accompanying the migraines.
