UVa hopes to participate in near-death experience Daily Press, VA - The study will involve patients who go into cardiac-arrest and whose hearts stop and are artificially restarted. Researchers will monitor the extent of ...
Closing the gender health gap Toronto Star, Canada - Medical researchers knew ? but many practitioners and women didn't ? that the most common symptoms of cardiac arrest in women are nausea, vomiting, ...
Perform CPR on gasping, grunting cardiac victims, expert says Canada.com, Canada - Nov 28, 2008 Almost half of people in cardiac arrest make gasping, grunting or snoring sounds -- which may stop bystanders from starting CPR because they think the ...
Everyone Agrees: Plax is in an Idiotic Mess Gothamist, NY - Nov 30, 2008 Once police can obtain a warrant from the DA's office, they are likely to arrest Burress on felony weapons charges since the only permit Burress had expired ...
Police honor two officers injured during drug raid Delaware News, OH - Nov 30, 2008 Two men were arrested in the incident and are in jail while awaiting trial. Both officers are 21-year veterans of the Division of Police and were in the ...
2009 Chevrolet Traverse is the Most Aerodynamic Lambda Automobile Magazine - According to the General, Buick's Enclave and Saturn's Outlook each has a higher drag coefficient of 0.36, while the GMC Acadia's 0.34 drag coefficient is ...
Alliant Energy Announces Second Quarter 2008 Results PR Newswire (press release), NY - Aug 6, 2008 An archive of the webcast will be available on the Company's Web site at http://www.alliantenergy.com/investors for 12 months. Alliant Energy is the parent ...LNT - KIDS
Amkor Reports Second Quarter 2008 Results MarketWatch - Aug 5, 2008 This call is being webcast by Thomson Financial and can be accessed at Amkor's web site at www.amkor.com. You may also access the call by dialing ...AMKR
Pre-Market: Market likely to remain rangebound Myiris.com, India - China`s Shanghai Composite rose 9.82 points, or 0.36%, to trade at 2729.19. South Korea`s Kospi index dropped 12.87 points, or 0.82%, to trade at 1565.84. ...
Gerdau SA Announces 1st Half 2008 Results CNW Telbec (Communiqu?s de presse), Canada - Metalurgica Gerdau SA shareholders will receive R$ 0.60 per share and Gerdau SA shareholders R$ 0.36 per share. -- EBITDA reaches R$ 4.7 billion in the 1st ...GGB - SAO:GOAU4
The calculation of web impact factors - P Ingwersen - Journal of Documentation, 1998 - ingentaconnect.com ... Countries in impact Web- IF Web- IF A/ inv. WIF /Web- IF web pages ... 4. Denmark 0.886
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Graphical Evolution of the Arnold Web: From Order to Chaos - C Froeschle, M Guzzo, E Lega - Science, 2000 - sciencemag.org ... 0 1 0.5 0.5 1.5 0.32 0.34 0.36 0.38 0.4 0 2.9 3.6 3.8 4 3.1 3 1 3.5 3.5 3 4 3 Fig.
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[PDF]Web response time and proxy caching - B Liu, G Abdulla, T Johnson, EA Fox - Proceedings of WebNet98, November, 1998 - pubs.dlib.vt.edu ... VT Library 0.3181 0.8828 0.36 Note: All times are in seconds ... This result suggests
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Metalyse treating out of hospital cardiac arrest of presumed cardiac origin: interim data review shows lack of benefit over placebo
Patient enrolment into TROICA, a randomized, double-blind, placebo-controlled Phase III clinical study of the single-bolus thrombolytic Metalyse ( Tenecteplase ) to assess the efficacy and safety of pre-hospital thrombolytic therapy in cardiac arrest of presumed cardiac origin, was suspended pending further blinded analysis of the study data.
This suspension followed the recommendation of an independent Data Safety Monitoring Board ( DSMB ) during a planned interim data review.
A preliminary data analysis showed that the probability the study will demonstrate superiority of Tenecteplase over placebo was very low.
The TROICA ( Thrombolysis in Cardiac Arrest ) study enrolled patients suffering from out-of-hospital cardiac arrest of presumed cardiac origin and without restoration of spontaneous circulation ( ROSC ).
The patients received Tenecteplase or matching placebo immediately after randomization and after first vasopressor injection within the standardized advanced cardiac life support ( ACLS ) and cardio pulmonary resuscitation-( CPR ) procedures.
These procedures were continued until the patients arrive at a cardiac or intensive care unit.
The primary endpoint of the trial was the 30-day survival rate and the co-primary endpoint was hospital admission. At the time the trial was suspended, approximately 1,000 of the 1,300 planned patients were enrolled.
Tenecteplase is a single-bolus thrombolytic agent approved by the European Commission in February 2001 for the treatment of acute myocardial infarction ( AMI ).
Tenecteplase is a bioengineered variant of Actilyse ( Alteplase, recombinant ), which is a recombinant DNA-derived version of naturally occurring tissue plasminogen activator ( t-PA).
It is constructed with amino acid substitutions at three sites.
Tenecteplase increases the risk of bleeding, including intracranial bleeding, and should be used only in eligible patients. In addition, thrombolytic therapy increases the risk of stroke, including hemorrhagic stroke, in elderly patients.
