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Recent News and Articles on the Keywords: cancer + breast + p95her  Related to the article below (Last Update: 12/1/2008)

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Recent News and Articles on the Keywords: cancer + breast + 391  Related to the article below (Last Update: 8/7/2008)

Events calendar
Monterey County Herald, CA -
A weekend of Breast Cancer fundraising events at Gardiner's Resort in Carmel Valley: Wine reception and dinner Friday, Aug. 8; On Saturday, Aug. ...
Craig Rowell
Nature.com (subscription), UK - Aug 1, 2008
Chemopreveition of Breast Cancer, Proteomic Discovery of Genistein Action in the Rat Mammary Gland The Journal of Nutrition 135 , 2953S-2959 (2005) Rowell C ...
Nationally Recognized Dr. Gino Tutera Celebrates Release of "Life ...
FOXBusiness - Jul 11, 2008
Tutera's ten-year documented research indicates a reduction of breast and ovarian cancer through pellet hormone replacement therapy. ...BKS - OTC:CMTX
Novartis gains momentum with strong performance in first half of ...
Ad-Hoc-News (Pressemitteilung), Germany - Jul 16, 2008
Femara (USD 561 million, +19% lc), an oral therapy for women withhormone-sensitive breast cancer, outpaced competitors and gainedshare in the aromatase ...NVS - BOM:500672 - ACL
POPULAR MUSIC Family Ev...
Akron Beacon Journal, OH - Jul 23, 2008
Rock for the Cure: Team Toni's Fight Against Breast Cancer ? Noon Sunday, Courtney's Village Inn, 3402 12th St. NW, Canton. Featuring A Separate Peace, ...
Entertainment events: Drive for a Cure Saturday, July 12, at Autohaus
Warrenton Journal, MO - Jul 8, 2008
Autohaus BMW is hosting the 12th annual BMW Ultimate Drive for The Susan G. Komen Breast Cancer Foundation from 9 am to 5:30 pm Saturday, July 12, ...

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Source: Google News

Lymphatic mapping and sentinel lymphadenectomy for breast cancer. -
AE Giuliano, DM Kirgan, JM Guenther, DL Morton - Annals of Surgery, 1994 - pubmedcentral.nih.gov
... Surg. 1994 September; 220(3): 391?401. Copyright notice. Lymphatic mapping
and sentinel lymphadenectomy for breast cancer. AE Giuliano ...

Improved axillary staging of breast cancer with sentinel lymphadenectomy. -
AE Giuliano, PS Dale, RR Turner, DL Morton, SW … - Annals of Surgery, 1995 - pubmedcentral.nih.gov
... Giuliano AE, Kirgan DM, Guenther JM, Morton DL. Lymphatic mapping and sentinel
lymphadenectomy for breast cancer. Ann Surg. 1994 Sep;220(3):391?401. [PubMed]; ...

… , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer -
J Li, C Yen, D Liaw, K Podsypanina, S Bose, SI … - Science, 1997 - sciencemag.org
... 133, 391 (1996) [Medline]; KK Wary, F. Mainiero, SJ Isakoff, EE Marcantonio, FE ... 5R35
CA39829), Amplicon Corporation, and the "1 in 9" breast cancer organization ...

Decreased expression of BRCA 1 accelerates growth and is often present during sporadic breast cancer -
ME Thompson, RA Jensen, PS Obermiller, DL Page, JT … - Nature Genetics, 1995 - nature.com
... al. Mutations in the BRCA1 gene in families with early-onset breast and
ovarian cancer. Nature Genet. 8, 387-391 (1994). | PubMed ...

… Compared with Lumpectomy and Radiation Therapy for the Treatment of Intraductal Breast Cancer -
B Fisher, J Costantino, C Redmond, E Fisher, R … - New England Journal of Medicine, 1993 - content.nejm.org
... Of 391 women treated by lumpectomy alone, ipsilateral breast cancer developed in
64 (16.4 percent); it was noninvasive in 32 and invasive in the remaining 32. ...

… of the cell-cycle inhibitor p 27 Kip 1 protein: Prognostic implications in primary breast cancer -
C Catzavelos, N Bhattacharya, YC Ung, JA Wilson, L … - Nature Medicine, 1997 - nature.com
... Expression of cell-cycle regulators p27 Kip1 and cyclin E, alone and in combination,
correlate with survival in young breast cancer patients. ... 133, 391 403 (1996 ...

Germline mutations of the BRCA 1 gene in breast and ovarian cancer families provide evidence for a … -
SA Gayther, W Warren, S Mazoyer, PA Russell, PA … - Nature Genetics, 1995 - nature.com
... al. Mutations in the BRCA1 in families with early onset breast and ovarian
cancer. Nature Genet. 8, 387-391 (1994). | Article ...

… Is Superior to Tamoxifen as First-Line Therapy for Advanced Breast Cancer in Postmenopausal Women: … -
JM Nabholtz, A Buzdar, M Pollak, W Harwin, G … - Journal of Clinical Oncology, 2000 - jcojournal.org
... Anastrozole Is Superior to Tamoxifen as First-Line Therapy for Advanced Breast Cancer
in Postmenopausal Women: Results of a North American Multicenter ...

… Without Further Axillary Dissection in Patients With Sentinel Node-Negative Breast Cancer -
AE Giuliano, PI Haigh, MB Brennan, NM Hansen, MC … - Journal of Clinical Oncology, 2000 - jcojournal.org
... Free Full Text]; National Institutes of Health: NIH consensus conference on the
treatment of early-stage breast cancer. JAMA 265:391-395, 1991[Medline]; Ivens D ...

… of Meat, Animal Products, Protein, and Fat and Risk of Breast Cancer: A Prospective Cohort Study in … -
P Toniolo, E Riboli, RE Shore, BS Pasternack - Epidemiology, 1994 - JSTOR
... animal origin, such as red meat, may be a factor in explaining the postulated role
of diet in breast cancer etiology. (Epide- miology 1994;5:391-397) Keywords ...

Source: Google Scholar
 
 

p95HER-2 helps predict breast cancer outcome

Researchers at Oregon Health & Science University Cancer Institute have identified a protein fragment in some human breast cancers that may help predict a chances of survival.

The presence of the fragment, called p95HER-2, in breast cancer tissue correlates closely with lymph node metastasis and earlier recurrence of the disease, suggesting that p95HER-2 is a marker and perhaps even involved in metastasis.

" By studying this marker we have a better chance to identify the patients who are more likely to have a longer disease-free survival," said Edward Keenan, one of the authors of the study.

The study, conducted in the lab of Gail Clinton, at OHSU School of Medicine, in collaboration with Keenan and investigators in Spain led by Jose Baselga, is published in the journal Clinical Cancer Research.

The study builds on observations the investigators have published over the last five years about the role of the HER-2 oncogene in breast cancer.
HER-2, a growth factor receptor, is overexpressed in 20 to 30 percent of breast cancer cases, but it has had limited usefulness in predicting clinical outcomes, particularly in early-stage breast cancer.

Researchers identified a fragment of full-length p185HER-2 that results from HER-2 cleavage, called p95HER-2, and developed an antibody that recognized it, making it possible to study the role of p95HER-2 in the spread of breast cancer.

The researchers studied breast cancer tissue from 483 biopsies from hospitals in the United States and Spain representing all stages of the disease. Two forms of the HER-2 protein were investigated: the full-length p185HER-2 receptor and its truncated form, p95HER-2. Only the truncated form proved to be a significant independent prognostic factor regarding clinical outcomes.

" More work is needed to determine if the presence of p95 has any significance regarding responsiveness of the cancers to chemotherapy, anti-estrogen therapy or Herceptin, a drug therapy for HER-2-related metastatic breast cancer," Keenan said. " Hopefully, understanding the significance of this marker will help us better specify effective therapy for individual patients."

Source: Oregon Health & Science University, 2006

 
 
 
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