Brain-cancer center at Swedish maps tumors to design treatment Seattle Times, United States - Nov 25, 2008 DuBose's cancer is the most common and aggressive type: glioblastoma multiforme, described as incurable by many experts. DuBose, who runs a carpet-cleaning ...
Vaccine to fight brain cancer KRCG, MO - Nov 7, 2008 Astrocytomas include the most common and devastating of all brain tumors -- glioblastoma multiforme (GBM). Another type of glioma is the brain stem glioma. ...
SuperGen, Inc. (F3Q08) Earnings Conference Call Transcript Seeking Alpha, NY - Nov 4, 2008 ... Food and Drug Administration (FDA) had granted orphan drug designation for our lead drug candidate MP-470 for the treatment of glioblastoma multiform. ...SUPG
Thought Leaders from Burzynski Research Institute, Inc. Present ... Trading Markets (press release), CA - Nov 20, 2008 Since antineoplastons effect approximately 100 genes instrumental in the growth of glioblastoma multiforme, the results of research will be presented in a ...
YM Biosciences Reports Data From Exploratory Clinical Trials of ... PipelineReview.com (press release), Spain - Nov 4, 2008 A preliminary survival analysis was conducted for all subjects with anaplastic astrocytoma and glioblastoma multiforme that received adjuvant radiotherapy. ...YMI
Nanomagnets tackle cancer Science News - Aug 4, 2008 The most advanced trial is currently studying some 65 patients with late-stage, recurrent glioblastoma multiforme, a type of brain cancer. ...
Immune and Clinical Responses Seen with Glioblastoma Vaccination Cancerpage.com, GA - Jul 17, 2008 ... a new study provide the first evidence that the T-cell response seen after therapeutic vaccination for glioblastoma multiforme is directly related to ...
Tasly Pharmaceutical H1 Net Up 40.93% Trading Markets (press release), CA - Aug 6, 2008 ... Yangxue Qingnao granule, which is for chronic cerebrovascular insufficiency, and Temozolomide Capsule, which is for glioblastoma multiforme.SHA:600535 - OTC:CMTX
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USA. Alterations of the PTEN gene occur in glioblastomamultiforme. ...
Isolation of cancer stem cells from adult glioblastoma multiforme - X Yuan, J Curtin, Y Xiong, G Liu, S Waschsmann- … - Oncogene, 2004 - nature.com ...Glioblastomamultiforme (GBM) is the most common adult primary brain tumor and is ...
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Glioblastoma multiforme: EGFRvIII, a new target for therapeutic drugs
Researchers at UT Southwestern Medical Center have discovered a cell-signaling mechanism instrumental in the most common brain cancer in adults.
The study, published in the journal Cancer Research, opens an avenue to develop therapeutic drugs to target the epidermal growth factor receptor genes that play a major role in the development of deadly brain tumors.
The median survival of patients with glioblastoma multiforme ( GBM ), a cancer of the supportive tissue of the brain, currently is about one year after diagnosis with the best treatments available, said Amyn Habib, at UT Southwestern and the senior author of study.
Glioblastoma multiforme, which accounts for 60 percent of brain tumors in adults older than 50 years, can infiltrate the brain extensively and sometimes becomes enormous before turning symptomatic.
Researchers have known for years that tumor cells proliferate out of control by a mechanism characterized by an abnormally high number of copies of the epidermal growth factor receptor gene ( EGFR ).
This overexpression of EGFR is a striking feature of glioblastoma multiforme, present in 40 percent to 50 percent of tumors and results in an uncontrolled multiplication of both normal EGFR and a mutant form called EGFRvIII.
While studying human brain tumor tissue and human brain tumor cells from cell lines grown in the laboratory, Habib and his colleagues discovered that EGFRvIII generates a unique pattern of signaling ( distinct from normal EGFR ) that causes brain cancer cells in glioblastoma multiforme to grow and multiply unchecked.
" The better we understand the signaling mechanisms of the normal and the mutant EGFR, the better we can manipulate or control them," Habib said. " Our findings suggest that you have to target both the mutant and the normal EGFR based on the mechanism we described."
Current standard treatment of glioblastoma multiforme consists of surgical removal of the tumor, followed by radiation and chemotherapy.
