You're not just making the doctor richer Nassau Guardian, Bahamas - Nov 17, 2008 Men should have a yearly rectal exam to check for colorectal cancer and prostate cancer after the age of 50. You should also have a stool guaiac test done ...
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Recent News and Articles on the Keywords: colorectal + 0.26 + 456 Related to the article below (Last Update: 8/7/2008)
Most Important Choice -- Schedule a Colorectal Exam Newswise (press release) - Newswise ? For many women, scheduling a screening for a colorectal cancer isn?t on the radar. Some mistakenly believe it?sa man?s disease. ...
Grant Received for Colorectal Screenings in Region 8 KAIT, AR - Aug 6, 2008 UAMS has received a $2.5 million grant to provide Colorectal Cancer screenings and education in St. Francis and Mississippi counties. ...
Sticking to diet advice cuts colon cancer risk Reuters - By Anne Harding NEW YORK (Reuters Health) - Current dietary guidelines are on the right track when it comes to colorectal cancer prevention, new research ...
Perceived Discrimination Affects Screening Rates Science Daily (press release) - 6, 2008) ? Minority men and women who perceived discrimination from their health care providers were less likely to be screened for colorectal or breast ...
Benefits of colonoscopy far outweigh minimal risks Asbury Park Press, NJ - Colonoscopy remains the gold standard for colorectal cancer screening. Any patient undergoing a medical procedure signs an informed consent stating the ...
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… reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma - J Chen, E Giovannucci, SE Hankinson, J Ma, WC … - Carcinogenesis - Oxford Univ Press ... and 45.1%, similar to that of the 456 added controls ... Risk of colorectal adenomas
among gly/gly individuals was not ... asp individuals (RR 0.66, 95% CI 0.26?1.70 ...
[PDF]APC Asp1822Val and Gly2502Ser polymorphisms and risk of colorectal cancer and adenoma. - GJ Tranah, E Giovannucci, J Ma, C Fuchs, DJ Hunter - Cancer Epidemiology, Biomarkers & Prevention, 2005 - mcardle.oncology.wisc.edu ... PHS cancer n 274 456 Gly/Gly 258 (95.6) 433 ... 3. Relationship between lifestyle factors
and colorectal adenoma risk ... 0.81 (0.57-1.15) [90; 132] 0.6 (0.26-1.39) [9 ...
Guaiac and immunochemical FOBT may identify more accurately individuals with colorectal cancer
Use of a simple test, in addition to traditional screening tests, identifies more accurately individuals who might have colorectal cancer.
This test, known as an immunochemical faecal occult blood test ( FOBT ), when used for individuals who have previously tested positive on initial screening with the more traditional guaiac FOBT, "could decrease substantially the number of false positives in a screening programme for colorectal cancer", according to lead author Callum G Fraser, and could reduce the need for colonoscopy in many individuals.
The guaiac-based FOBT, which detects blood ( haemoglobin ) in the faeces, is currently used to screen individuals for colorectal cancer. However, although this test is cheap and relatively easy to do, it is not very accurate and has a low clinical sensitivity and specificity since cancer is not the only cause of a positive result. Nevertheless, individuals who are positive in this test are followed-up by colonoscopy, a more expensive procedure that has some associated risks.
Fraser and colleagues proposed that individuals who are only weakly or moderately positive in the guaiac test could be selected further by use of an immunochemical test, thereby distinguishing individuals who are less likely to have cancer, and thus sparing them the additional colonoscopic examination.
A total of 1486 participants who were guaiac FOBT positive were invited to participate, and around 50% returned samples for testing with the immunochemical test.
Of these individuals, 173 ( 22% ) tested negative in both samples provided ( N/N ), 129 ( 16% ) tested positive in one of two samples ( N/P ), and in 498 ( 62% ) participants both samples were found to be positive ( P/P ).
Only one patient in each of the N/N and N/P groups had colorectal cancer compared with 38 ( 8% ) of the P/P participants. The odds ratio for P/P participants having cancer was 7.57 compared to a reference group of N/N and N/P individuals.
" Although immunochemical FOBT is more expensive than guaiac FOBT, its use in testing those who are weak positive on initial guaiac FOBT would reduce the need for colonoscopy by about 30%. The implications for national screening programmes are important in terms of reducing costs, inconvenience, and associated morbidity, without compromising the effectiveness of screening". Fraser said.
