Recent News and Articles on the Keywords: prostate cancer + cancer + gene  Related to the article below (Last Update: 8/7/2008)

Clarient and Health Discovery Corporation Announce Results from ... Business Wire (press release), CA - In the United States alone, there are over 1 million prostate cancer tissue biopsy procedures performed annually. Approximately 25% of these tissue biopsies ...OTC:HDVY - CLRT deCODE genetics Announces Second Quarter 2008 Financial Results MarketWatch - Skin cancer. deCODE discovered sequence variants near the ASIP (agouti signaling protein) gene on chromosome 20 that greatly increase the likelihood of an ...DCGN Cancer Cures Find Biology-Physics Convergence With MIT `Genius' Bloomberg - MIT biologists were involved in the original gene discoveries that led to the cancer drug Herceptin, made by South San Francisco-based Genentech Inc., ... Clarient and Health Discovery Announce Results from Prostate ... RTT News, NY - ... they have completed the three-phased, double-blind clinical validation studies for their new gene-based molecular diagnostic test for prostate cancer. ...OTC:HDVY - CLRT Cell Genesys to Present at the 28th Annual Canaccord Adams Global ... Earthtimes (press release), UK - Ongoing clinical trials include Phase 3 trials of GVAX immunotherapy for prostate cancer, which is being developed in partnership with Takeda Pharmaceutical ...CEGE Sydney Morning Herald Perils in dealing with online genetic tests Sydney Morning Herald, Australia - An overweight smoker aged 50-plus, with a strong family history of the cancer, would get much the same prognosis from a doctor, she says. ... Renowned Prostate Cancer Expert, Dr. Colin Collins, Joins ... FOXBusiness - In addition to his work in prostate cancer, Dr. Collins's laboratory was responsible for the discovery of the ZNF217 gene and for elucidating its critical ...CBMX - OTC:CYOE - OTC:CMTX BBC News Cases of prostate cancer have gone up but a cure is on the way Daily Nation, Kenya - Jul 24, 2008 Studies have indicated that Asians are least likely to have this gene, explaining why they have the lowest rates of prostate cancer. ... Science could halt the cancer domino effect Times Online Bespoke cancer therapy raises vital question of cost Times Online all 491 news articles » Breast cancer: What you need to know Food Consumer, IL - Aug 5, 2008 High levels of IGF-1 have been linked to elevated risk of prostate cancer, breast cancer and colon cancer, according to a study published in the December ... Genomic Health Announces Second Quarter 2008 Financial Results and ... eMediaWorld.com Newswire Press Release Distribution Service (press release), AZ - Aug 5, 2008 Other Cancers -- Established collaborators and identified sources of clinical samples to further our prostate and lung cancer programs. -- Began gene ...GHDX

Variations in growth-factor gene linked to risk of prostate cancer

Researchers from the Keck School of Medicine of the University of Southern California, the Broad Institute of Harvard and MIT, and the University of Hawaii, found that two variations in the gene for insulin-like growth factor I ( IGF-1 ) are linked to an increased risk of prostate cancer.

" Our results suggest that inherited variation in IGF1 may play a role in prostate cancer risk," write the researchers in a paper published in the Journal of the National Cancer Institute.

Researchers were able to tease out the relevant gene variations using data from the large Multiethnic Cohort study.
This population-based cohort study has collected data on more than 215,000 men and women from Los Angeles and Hawaii over the past decade.

From this cohort and information from cancer registries in California and Hawaii, the researchers were able to identify 2320 men who had developed prostate cancer and match them with 2290 men who did not have a prostate cancer diagnosis.

The team knew that high circulating levels of IGF-1 had been linked by previous studies to an increase in prostate cancer risk, and so they focused on that gene and its single-nucleotide polymorphisms ( SNPs ).
What they found was that several SNPs across the gene were linked to an increased risk of prostate cancer, and two particular SNPs were identified that could account for the genetic associations they observed.
Ten percent of the prostate cancer cases in this study could be explained by the variation in DNA sequence of these two polymorphisms.

Because of the ethnic diversity in the cohort's population, included in the group are African Americans, Hawaiians, Japanese Americans, Latinos and whites, the researchers were also able to look at the risk associated with the two SNPs across the five different ethnic groups. As it turned out, the increase in risk was the same throughout all the sub-groups, " suggesting that the inherited variation in IFG1 behaves similarly among ancestral groups and shares an overall biologic effect," the researchers observed.

" Our study critically evaluates the possibility of false positive results, and important issue faced by genetic association studies, and provides strong support for the involvement of the IGF pathway in the development of prostate cancer," Cheng noted. " By identifying the mechanisms in which inherited differences in IGF1 influence disease, we will further advance our understanding of prostate cancer biology and disease susceptibility."

Source: University of Southern California, 2006