District Lions walk for diabetes awareness Scranton Times-Tribune, USA - Nov 30, 2008 Now in the US, diabetic retinopathy is the number-one cause of vision loss in adults. This Lions event was a coordinated effort by a diabetes committee, ...
Support Groups GoErie.com, PA - Caregivers support group, for friends, spouses, relatives or caregivers of someone with severe vision loss, light supper will be served, Tuesday, 6 to 7 pm, ...
Diabetes Vision First Coast News, FL - Nov 24, 2008 Diabetics are also more likely to develop glaucoma, a disease that damages the optic nerve. A laser treatment prevented Martinez from further vision loss. ...
Diabetic patients at higher risk for vision loss, eye disease Shelby Township Source Newspapers, MI - Nov 14, 2008 Diabetics are at a higher risk of complications such as dental disease, amputations and vision loss. In fact, nearly half of all diabetics have some form of ...
Beware! Clouded vision is a pointer to diabetes Sify, India - Nov 14, 2008 It could be an indication of diabetes and could even lead to loss of vision if left untreated, say doctors. Diabetic retinopathy is a serious condition of ...
Group aims to test 1 million for World AIDS Day CBC.ca, Canada - "We see people who have increased risk of diabetes. We see increased cases of renal failure, kidney failure. We see folks who get osteoporosis. ...
Living the sweet life Malaysia Star, Malaysia - Nov 29, 2008 This leads to persistently high blood glucose levels, potentially leading to numerous complications such as coronary artery disease, stroke, diabetic...
Study: Diabetes Drug Avandia Riskier Than Actos eFluxMedia - Nov 25, 2008 ... of heart attack by 40 percent, doubles the risk of heart failure and bone fractures and increases the risk of anemia and vision loss from macular edema. ...
People with Diabetes Urged to Have Their Hearing Checked Regularly PR Newswire (press release), NY - Nov 10, 2008 Both vision loss and hearing loss are associated with diabetes. Studies conducted by BHI show that people with untreated hearing loss have a lower quality ...
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Recent News and Articles on the Keywords: diabetic retinopathy + diabetes + loss Related to the article below (Last Update: 8/7/2008)
Care of visionand ocular health in diabetic members of a national ... 7thSpace Interactive (press release), NY - Jul 29, 2008 Regular examination and early treatment of diabetic retinopathy can prevent visual loss. The aim of the study was to describe the care of vision and ocular ...
Diabetic Hispanics Not Receiving Proper Eye Care Medical News Today, UK - Jul 18, 2008 About 20% of Hispanic individuals over 40 years old suffer from diabetes and about 50% of these have the eye condition called diabetic retinopathy, ...
Checks-up alert for diabetic eye problems Trade Arabia, Bahrain - Jul 15, 2008 If left undetected, diabetes retinopathy can lead to vision loss and blindness, Dr Canning, who is also consultant ophthalmologist/vitreoretinal surgeon at ...
Regular eye check-ups 'vital for diabetics' GulfNews, United Arab Emirates - Jul 15, 2008 According to figures provided by the Diabetes Centre, up to 21 per cent of people with diabetes Type 2 have retinopathy when first diagnosed, while others ...
New AACE Guidelines for Prediabetes Management Medscape (subscription) - Jul 25, 2008 In the Diabetes Prevention Program, approximately 8% of patients with impaired glucose tolerance had diabetic retinopathy as did nearly 13% of those whose ...
Dunedin researcher (83) makes diabetes breakthrough Otago Daily Times, New Zealand - Jul 14, 2008 What the diagram showed was the loss of pericytes, a type of cell, in people with type-one diabetes. "All the information was there, but no-one has come up ...
Laser Superior to Corticosteroids in Diabetic Macular Edema DG News - Jul 28, 2008 "Our findings raise the possibility that combining laser with corticosteroids might produce greater benefit," said Neil Bressler, MD, Diabetic Retinopathy...
Pericytes and the pathogenesis of diabetic retinopathy - HP Hammes - Horm Metab Res, 2005 - thieme-connect.com ... The pharmacological prevention of acellular capillaries without the rescue of pericyte loss in experimental diabeticretinopathy suggests that the endothelium ...
The 14-year incidence of visual loss in a diabetic population. - SE Moss, R Klein, BE Klein - Ophthalmology, 1998 - ncbi.nlm.nih.gov ... In univariate analyses, loss of vision as measured ... older age, longer duration of diabetes, higher glycosylated ... of macular edema, and more severe retinopathy. ...
Ten-year incidence of visual loss in a diabetic population. - SE Moss, R Klein, BE Klein - Ophthalmology, 1994 - ncbi.nlm.nih.gov ... persons with younger-onset and older-onset diabetes who were ... of macular edema or
more severe retinopathy was associated with more visual loss in all ...
[PDF]Pathogenesis of diabetic retinopathy - RL Engerman - Diabetes, 1989 - diabetes.org ... be influenced in vivo by pericyte loss (5). Capillary ... is a characteristic feature
of diabetic retinop- athy ... seemingly begins at an early stage of retinopathy. ...
Epidemiology of proliferative diabetic retinopathy. - R Klein, BE Klein, SE Moss - Diabetes Care, 1912 - ncbi.nlm.nih.gov ... In the WESDR, a significant number of diabetic people with proliferative retinopathy
at risk for vision loss were not under the care of an ophthalmologist or ...
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Ruboxistaurin reduces the risk of vision loss caused by diabetic retinopathy
Results from an analysis of pooled data from two, three-year phase 3 trials showed that Ruboxistaurin ( Arxxant ) reduced the risk of sustained moderate vision loss by 41 percent when compared to placebo in patients with moderate to severe, nonproliferative diabetic retinopathy. Vision loss occurred in only 6.1 percent of patients treated with Ruboxistaurin compared to 10.2 percent of patients treated with placebo.
Ruboxistaurin limits protein kinase C beta ( PKC beta ) overactivation, and it is the first of a new class of compounds being investigated for the treatment of diabetic retinopathy.
The laboratory of George L. King, at Joslin Diabetes Center, first proposed that PKC beta activation is responsible for the development of diabetic retinopathy and other microvascular damages induced by diabetes.
The combined analysis examined a total of 813 patients treated with 32 mg per day of Ruboxistaurin ( n=412 ) or placebo ( n=401 ) derived from two multi-center, randomized, placebo-controlled, double-masked, phase 3 trials that were similar in design and implementation.
The analysis examined whether Ruboxistaurin could reduce the risk of long-term, or sustained moderate vision loss caused by diabetic retinopathy.
Patients had moderate to severe nonproliferative diabetic retinopathy at the start of the study.
The beneficial effect of ruboxistaurin was not accompanied by a reduction in the progression of study patients from nonproliferative to proliferative diabetic retinopathy.
Vision loss ( measured in the study as sustained moderate vision loss ) occurred in only 6.1 percent of patients treated with Ruboxistaurin compared to 10.2 percent of patients treated with placebo, equaling a 41 percent relative risk reduction ( P=0.011 ) over three years.
Vision loss was defined as a three-line loss on the eye chart that was sustained for at least 6 months.
A separate analysis of data from 11 studies, of the safety of 32 mg per day of Ruboxistaurin in patients with at least one diabetic microvascular complication ( including diabetic retinopathy ), found Ruboxistaurin was generally well tolerated and had an overall adverse event profile, as well as a serious adverse event profile similar to placebo.
Serious adverse events occurred in 23.2 percent of patients taking placebo compared to 20.8 percent of patients taking Ruboxistaurin.
In addition, Ruboxistaurin had no effect on glucose or blood pressure control.
This data presentation reported on a clinical safety data base which includes a total of 2,804 patients with type 1 or type 2 diabetes combined from 11 phase 2 and 3 placebo-controlled, double-masked trials, for up to four years.
The only treatment-emergent adverse event that occurred with a frequency of greater than or equal to two percent and occurred significantly more often in the ruboxistaurin group was indigestion.
Diabetic retinopathy is a relatively common microvascular complication in individuals with diabetes that can lead to a sudden and debilitating impact on vision.
In the United States, an estimated 4.1 million adults aged 40 and older have diabetic retinopathy ( 40.3% of persons with diabetes mellitus) with 899,000 having vision-threatening retinopathy ( 8.2% ).
For persons with type 1 diabetes, the crude prevalence of diabetic retinopathy is about 80%.
Source: 66th Annual Scientific Sessions - American Diabetes Association ( ADA ), 2006
