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Recent News and Articles on the Keywords: cancer + cervical + hycamtin  Related to the article below (Last Update: 12/1/2008)

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Recent News and Articles on the Keywords: cervical cancer + cancer + cervical  Related to the article below (Last Update: 8/7/2008)

Is this normal ovulation? Or it is a sign of cervical cancer?
Daily Monitor, Uganda -
Or it is a sign of cervical cancer? The vagina and cervix make some fluid which flows out of the vagina, removing old worn out cells that line the vagina ...
GSK launches cheaper cervical cancer vaccine
Business Daily Africa, Kenya -
GlaxoSmithKline managing director, Dr John Musunga (left), addresses the Press during the launch of a cervical cancer vaccine in Nairobi. ...

RTE.ie
Concern voiced over limits to cervical cancer vaccinations
Irish Times, Ireland - Aug 5, 2008
The commencement of cervical cancer vaccination was welcomed by the Irish Cancer Society. However it, too, expressed disappointment the programme will be ...
Anti-cancer vaccine eGov monitor
Harney approves cervical cancer vaccination programme Belfast Telegraph
Cervical cancer vaccine programme announced RTE.ie
BBC News - Irish Times
all 30 news articles »

Nation News
Boost for QEH cancer fight
Nation News, Barbados -
... HOSPITAL has got a boost for its cancer detection programme with the presentation of a colposcope to assist in early detection of cervical cancer. ...
A survivor?s battle with cervical cancer
Inquirer.net, Philippines - Aug 4, 2008
By Anne Jambora MANILA, Philippines?No woman has to go through the horrors of cervical cancer, now the second leading cause of death among Filipino women. ...
German Association of Gynecology and Obstetrics Recommends HPV ... Earthtimes (press release)
all 18 news articles »

CTV.ca
Prostate cancer rate spurs campaigners
So Md News, MD -
Mary Emily Whelan, a community outreach worker with the health department?s breast and cervical cancer program, will be working a few days a week at the Bel ...
Prostate Cancer Screening: Making Decisions Without Evidence Wall Street Journal Blogs
Will Older Men Give Up the PSA Test? New York Times
all 769 news articles »
Measuring Cancer Therapy Success With Oxygen
Science Daily (press release) - Aug 5, 2008
In their study of 88 women with cervical cancer, Dr. Wang and his colleagues measured the level of hemoglobin, the oxygen-carrying molecule in blood, ...

Ottawa Citizen
Breast cancer screenings: How soon to start?
WRAL.com, NC -
Her mother is a two-time breast cancer survivor and has also had cervical cancer. Only 5 to 10 percent of breast cancer cases are inherited, which means a ...
AssociatedPress
Who's in the news National Post
Applegate diagnosed with cancer ITN
Reuters - Now Magazine Online
all 1,012 news articles »
Cancer: World`s worst killer
Triumph, Nigeria -
Others include lung cancer, colon cancer, endometrial cancer, ovarian cancer and cervical cancer. According to experts, breast cancer, which can occur at ...
UI cancer specialists on cutting edge
Iowa City Press Citizen, IA - Aug 6, 2008
The UI clinical study is being financed with funds from the John and Mary Pappajohn Clinical Cancer Fund. The fund has offered to pay for the LUMA cervical ...
Source: Google News

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective -
FX Bosch, MM Manos, N Munoz, M Sherman, AM Jansen, … - jnci, 1995 - jnci.oxfordjournals.org
... R. Pfeiffer, and RD Burk Age-Related Changes of the Cervix Influence Human ... Mouchawar,
K. Bischoff, MU Yood, J. Gilbert, and SH Taplin Cervical Cancer in Women ...

Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer -
N Munoz, FX Bosch, S de Sanjose, R Herrero, X … - New England Journal of Medicine, 2003 - content.nejm.org
... Impact of the Human Papilloma Vaccine on Cervical Cancer. ... Concentrations and Clearance
of Incident Oncogenic Human Papillomavirus Infection of the Cervix. ...

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide -
JMM Walboomers, MV Jacobs, MM Manos, FX Bosch, JA … - The Journal of Pathology, 1999 - doi.wiley.com
... of integrated human papillomavirus type 16 DNA in cervical cancer: amplification
of ... 8. zur Hausen H. Molecular pathogenesis of cancer of the cervix and its ...

… Concurrent Chemotherapy Compared with Pelvic and Para-Aortic Radiation for High-Risk Cervical Cancer -
M Morris, PJ Eifel, J Lu, PW Grigsby, C Levenback, … - New England Journal of Medicine, 1999 - content.nejm.org
... Carcinoma of the Uterine Cervix: Twice- versus Once-weekly High-Dose-Rate Brachytherapy. ...
Cervical Cancer: Prevention, Diagnosis, and Therapeutics. ...

Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer -
PG Rose, BN Bundy, EB Watkins, JT Thigpen, G Deppe … - New England Journal of Medicine, 1999 - content.nejm.org
... locally advanced cervical cancer. Women with primary untreated invasive
squamous-cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix ...

Relation of human papillomavirus status to cervical lesions and consequences for cervical-cancer -
MA Nobbenhuis, JM Walboomers, TJ Helmerhorst, L … - Lancet, 1999 - ncbi.nlm.nih.gov
... BACKGROUND: A relation has been established between infection with high-risk types
of human papillomavirus and development of cervical cancer. ...

The causal relation between human papillomavirus and cervical cancer -
FX Bosch, A Lorincz, N Munoz, C Meijer, KV Shah - British Medical Journal, 2002 - jcp.bmj.com
... presented separately for squamous cell carcinomas and adenocarcinomas of the cervix. ...
association of human papillomavirus (HPV) DNA and cervical cancer in the ...

… -Specific Persistence of Human Papillomavirus DNA before the Development of Invasive Cervical Cancer -
KL Wallin, F Wiklund, T Angstrom, F Bergman, U … - New England Journal of Medicine, 1999 - content.nejm.org
... in a population-based screening program for cancer of the cervix in Sweden from
1969 to 1995, we compared the proportion of normal cervical smears (Pap smears ...

… DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. -
M Boshart, L Gissmann, H Ikenberg, A Kleinheinz, W … - The EMBO Journal, 1984 - pubmedcentral.nih.gov
... Copyright notice. A new type of papillomavirus DNA, its presence in genital cancer
biopsies and in cell lines derived from cervical cancer. ...

The Papanicolaou test for cervical cancer detection. A triumph and a tragedy -
LG Koss - JAMA, 1989 - Am Med Assoc
... treatment of precancerous lesions and early cancer of the uterine cervix is described ...
is the screening and interpretation of cervical (Papanicolaou) smears ...

Source: Google Scholar
 
 

Advanced cervical cancer: FDA has approved a combination of Hycamtin and Cisplatin

The FDA ( Food and Drug Administration ) has approved a combination of Hycamtin ( Topotecan ) and Cisplatin for use as the first drug treatment for women with late-stage ( stage IVB ) cancer of the cervix when surgery or radiation therapy are unlikely to be effective.

Hycamtin was approved in 1996 for treating ovarian cancer and in 1998 for small cell lung cancer.

In clinical trials, a total of 293 patients were randomized to Hycamtin plus Cisplatin or to Cisplatin alone.
Most of the participants had received prior radiation therapy as the standard treatment, while some may have undergone prior surgery.
The combination therapy significantly improved survival compared to the use of Cisplatin alone. Patients on combined therapy survived ( 9.4 months ), about three months longer than patients on Cisplatin alone ( 6.5 months ).

Hycamtin is associated with a significant risk of neutropenia, a condition which makes it more difficult for the body to fight infections. Serious side effects also include thrombocytopenia, a decrease in blood platelets that can lead to excessive bleeding and anemia.
Less serious side effects include nausea and vomiting.
The incidences of neutropenia, anemia, and thrombocytopenia were significantly increased among patients receiving the combination treatment compared to those receiving Cisplatin alone, as were nausea and vomiting, mucositis, rash, and liver toxicity.

In the United States there are an estimated 10,000 new cases of cervical cancer and about 3,700 related deaths each year.

Source: FDA, 2006

 
 
 
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