FDA: Novartis malaria pill shows superior results International Herald Tribune, France - But as much as 40 percent of the world's population is at risk, mostly in the poorest countries. Drug resistance also has been a major hurdle in the ...NVS
ScientIST: 20th Anniversary of World AIDS Day LAist, CA - 25 minutes ago Drug resistance and complete protective vaccination, therefore, are major hurdles for virologists. Of course you know. But let?s review anyway. ...
One high-risk group still cries for attention Expressindia.com, India - Because, failure to get treatment eventually leads to resistance to frontline drugs. Pardeshi also unhappy that the proposed link ART centres are not ...
Survival, plasma HIV-1 RNA concentrations and drug resistance in ... World Health Organization (press release), Switzerland - HIV-1-infected adolescents and youth on ART have poor adherence and high rates of virologic failure and drug-resistant viruses, and they are at risk for HIV ...
And the battle against AIDS continues The Guardian - Nigeria, Nigeria - The PLWHAN are also worried that if they miss their drugs for whatever reasons, the virus will become resistant to the drugs rendering them useless and the ...
Age-related macular degeneration: economic burden and value-based medicine analysis - MM Brown, GC Brown, JD Stein, Z Roth, J Campanella … - Can J Ophthalmol, 2005 - pubs.nrc-cnrc.gc.ca ... suggests that each year 180000 new cases of dry AMD and 17100 new cases ... Finally,
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Near-Infrared Classification Spectroscopy: H-Band Spectra of Fundamental MK Standards - MR Meyer, S Edwards, KH Hinkle, SE Strom - The Astrophysical Journal, 1998 - UChicago Press ... These fits format files, which are useful plotting routines, and other relevent
information are also available on the World Wide Web at http ... 15600, 17100, 19000. ...
Sub-Milliarcsecond Imaging of Quasars and Active Galactic Nuclei - KI Kellermann, RC Vermeulen, JA Zensus, MH Cohen - The Astronomical Journal, 1998 - iop.org ... 1308]326 ..... 13 10 28.664 32 20 43.78 BL 19.0 1.00 1.53 1323]321 .....
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Cooking Enhances the Antioxidant Properties of Polyphosphates - DM WEILMEIER, JM REGENSTEIN - Journal of Food Science, 2004 - Blackwell Synergy ... 69, Nr. 1, 2004 Published on Web 12/18/2003 ... nr 17100; DuPont Instruments, Newtown,
Conn., USA). ... Day 1 STPP 0.29 ? 0.34 0.15 ? 0.02 0.25 ? 0.20 0.28 ? 0.37...
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Two-dimensional gel protein database of Saccharomyces cerevisiae F Bordeaux, B MolCculaire, CEA Saclay - Electrophoresis, 1996 - doi.wiley.com ... In all, 600 spots are annotated. These data can be accessed on the Yeast Protein
Map server through the World Wide Web network. 1 Introduction ... -
Small molecules overcome drug resistance in cancers associated with high-risk viruses
Treatment of human cancer is often impeded when cancer cells develop resistance to drugs that are designed to induce a type of programmed cell death called apoptosis.
A study published in the Cancer Cell identifies compounds and mechanisms that can overcome a specific type of resistance to chemotherapeutic-induced apoptosis.
The findings may have application for treatment of cancers that are linked to the human papilloma virus ( HPV ) oncoprotein E6, such as cervical cancer.
Certain viral oncoproteins, including HPV E6, are known to interfere with the function of a protein called p53, a key tumor suppressor involved in apoptosis.
Loss of p53 is linked to uncontrolled cell proliferation, the hallmark of cancer, and is known to increase the resistance of tumor cells to some chemotherapeutic treatments. HPV is a major cause of cervical cancer, and earlier studies have suggested that interfering with E6 may lead to the death of E6-expressing cells. However, methods used to target E6 in these studies involved techniques that are not easily translatable to therapeutic use, and at this time, no specific therapies exist.
Brent R. Stockwell and colleagues from Columbia University designed a study to uncover small molecules that can overcome E6-induced drug resistance and which would be more easily adaptable to cancer treatment.
The researchers used a screening method to look for compounds that potentiate chemotherapeutic effectiveness of the agent doxorubicin in E6-expressing colon cancer cells that are normally relatively resistant to the drug.
" We identified several groups of compounds that potentiate doxorubicin's lethality in E6-expressing tumor cells, thus overcoming E6-induced drug resistance," offers Stockwell.
Results describe one group of compounds, named indoxins, that proved to be dual-action agents that drive two distinct cell cycle-related mechanisms.
Stockwell explains that activation of each mechanism alone had only a modest effect on chemotherapeutic effectiveness, but activation of both mechanisms simultaneously contributed substantially to doxorubicin sensitivity. Enhanced understanding of the mechanisms that are associated with doxorubicin resistance will lead to design of future therapies that can be specifically targeted to overcome drug resistance in E6-expressing tumors.
