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Recent News and Articles on the Keywords: leukemia + oncaspar + acute  Related to the article below (Last Update: 12/1/2008)

 News results: Standard Version | Text Version | Image Version Results 1 - 2 of 2 for leukemia oncaspar acute. (0.12 seconds) 
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Enzon Reports Solid Third Quarter 2008 Results
MarketWatch - Nov 5, 2008
... 2008 compared to the same period of 2007 was attributable primarily to higher revenues from Oncaspar for the treatment of Acute Lymphoblastic Leukemia ...ENZN
Penny Stocks Alert ? Hot Stocks Alert for SBLK, IDMI, ENZN
PRLog.Org (press release), Romania - Nov 19, 2008
Its products include Oncaspar, a PEG-enhanced version of a naturally occurring enzyme called L-asparaginase derived from E.coli, and is used in conjunction ...SBLK - IDMI - ENZN
Source: Google News


 

Recent News and Articles on the Keywords: oncaspar + acute + leukemia  Related to the article below (Last Update: 8/7/2008)

Enzon Reports Solid Second Quarter 2008 Results
Business Wire (press release), CA -
Oncaspar continues to be adopted in cooperative protocols for the first-line treatment of patients with acute lymphoblastic leukemia for both pediatric and ...ENZN
Source: Google News

… of Early Response to a Single Dose of Asparaginase in Childhood Acute Lymphoblastic Leukemia. -
BL Asselin, S Kreissman, DJ Coppola, SD Bernal, PR … - Journal of Pediatric Hematology Oncology, 1999 - jpho-online.com
... Enzon, South Plainfield, NJ, provided pegaspargase (Oncaspar). ... Therapy with Erwinia
L- asparaginase in children with acute leukemia after anaphylaxis to E ...

… of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer … -
VI Avramis, S Sencer, AP Periclou, H Sather, BC … - Blood, 2002 - bloodjournal.hematologylibrary.org
... and polyethylene glycol conjugated asparaginase for treatment of children with newly
diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer ...

The best way to use asparaginase in childhood acute lymphatic leukaemia-still to be defined? -
JPV Pinheiro, J Boos - British Journal of Haematology, 2004 - Blackwell Synergy
... IU/m 2 of the PEG asparaginase preparation Oncaspar TM ... induction remission rates
in childhood relapsed acute lymphoblastic leukemia: a Pediatric ...

… (Oncaspar (R)) for the First-Line Treatment of Children with Acute Lymphoblastic Leukemia (ALL) -
PA Dinndorf, J Gootenberg, MH Cohen, P Keegan, R … - The Oncologist, 2007 - theoncologist.com
... FDA Drug Approval Summary: Pegaspargase (Oncaspar?) for the First-Line Treatment
of Children with Acute Lymphoblastic Leukemia (ALL). ...

Pegylated asparaginase (OncasparTM) in children with ALL: drug monitoring in reinduction according … -
HJ Muller, L Loning, A Horn, D Schwabe, M Gunkel, … - British Journal of Haematology, 2000 - Blackwell Synergy
... intensity of one dose of 1000 U/m 2 BSA Oncaspar TM should ... and antibody formation
during l-asparaginase treatment of children and adults with acute leukemia . ...

… evaluate plasma anti-asparaginase IgG concentrations in patients with acute lymphoblastic leukemia -
B Wang, LJ Hak, MV Relling, CH Pui, MH Woo, MC … - Journal of Immunological Methods, 2000 - Elsevier
... been widely used to treat acute lymphoblastic leukemia ... reactions to asparaginase
in leukemia patients have ... CAMR, Salisbury, UK) and PEG (Oncaspar, Enzon, Inc ...

… crossreaction of antiasparaginase antibodies in acute lymphoblastic leukemia (ALL) and lymphoma … -
B Wang, MV Relling, MC Storm, MH Woo, R Ribeiro, … - Leukemia, 2003 - nature.com
... to asparaginase does not impact treatment outcome of childhood acute lymphoblastic
leukemia. ... PubMed | ChemPort |; Oncaspar prescribing information ...

Drug monitoring of low-dose PEG-asparaginase (Oncaspartm) in children with relapsed acute -
JP Vieira Pinheiro, HJ Muller, D Schwabe, M Gunkel … - British Journal of Haematology, 2001 - Blackwell Synergy
... into the German market, PEG-ASNase (Oncaspar?) was approved for ... to Erwinia
asparaginase in children with acute lymphoblastic leukemia who had ...

… induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukemia -
D Douer, H Yampolsky, LJ Cohen, K Watkins, AM … - Blood, 2007 - bloodjournal.hematologylibrary.org
... a standard component in most treatment protocols for acute lymphoblastic leukemia
(ALL), 1 ... Pegaspargase (Oncaspar) is a modified form of native E ...

… on pegylated asparaginase used in front-line treatment of children with acute lymphoblastic leukemia -
C Rizzari, M Citterio, M Zucchetti, V Conter, R … - Haematologica, 2006 - haematologica.org
... Acute Lymphoblastic Leukemia ? Research Paper ... The study drug was pegylated E.
coli asparaginase (Oncaspar ?, Medac GmbH, Hamburg, Germany ...

Source: Google Scholar
 
 

Oncaspar for newly-diagnosed acute lymphoblastic leukemia

The FDA ( Food and Drug Administration ) has expanded the approved use of Oncaspar ( Peg-Asparaginase ) to include treating children and adults with newly diagnosed acute lymphoblastic leukemia ( ALL ) as part of a multiple drug chemotherapy regimen.

FDA previously approved Oncaspar in 1994 only for patients with acute lymphoblastic leukemia who were unable to receive the cancer drug L-Asparaginase because they were allergic to that drug.

An estimated 25,000 new cases of leukemia will be diagnosed in the United States during 2006. Of these new leukemia cases, approximately 6,500 will be the ALL type of leukemia, of which approximately 2,500 will occur in children and 4,000 will occur in adults.

The use of Oncaspar in place of the currently used drug, L-Asparaginase, markedly reduces the number of drug injections required, from 21 injections of Elspar ( L-Asparaginase ), which has been the standard of care, to three injections with Oncaspar over the 20-week course of treatment.

The approval is based on a randomized multi-center trial, conducted by the Children's Cancer Group, in 118 pediatric patients.
In the trial, researchers demonstrated that Oncaspar could be safely and effectively substituted for Elspar as part of a multi-drug cancer regimen.

Serious side effects with Oncaspar include anaphylaxis ( allergic shock ), other serious allergic reactions, blood clots, stroke, pancreatitis, glucose intolerance and bleeding problems.

Source: FDA, 2006

 
 
 
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