Protein That Determines Cell Polarity Prevents Breast Cancer... Science Daily (press release) - Nov 26, 2008 The targets of tumor suppressors are usually cancer-causing genes, or oncogenes, such as Myc, which past research has shown to be overexpressed, ie, ...
Doctors, researchers on quest for a cure News-Herald.com, OH - Nov 28, 2008 For example, three receptors known to fuel most breast cancer tumors are progesterone, estrogen and Human Epidermal Growth Receptor 2, also called HER-2. ...
Cell cycle arrest in metformin treated breast cancer cells ... 7thSpace Interactive (press release), NY - 52 minutes ago The antihyperglycemic drug metformin may have beneficial effects on the prevention and treatment of cancer. Metformin is known to activate AMP-activated ...
Source: Google News
Recent News and Articles on the Keywords: web + cancer + 100 Related to the article below (Last Update: 8/7/2008)
Woman cycles into Rainy River to raise awareness for cancer... Rainy River Record, Canada - Rainy River was the half way point on her 100 day journey and her progress can be tracked on the Caring Voices web site. Anyone wanting information about ...
Bull riding event raises &#e6;30000 for cancer assistance Business Gazette, MD - ... can donate 100 percent of its proceeds to the intended recipients. To date, the charity has raised more than &#e6;2 million according to its Web site. ...
Who Is Capable of Crashing the Phelps Party? New York Sun, United States - The 24-year-old swimmer plans to race the 200 breaststroke even after being diagnosed with testicular cancer in July. Phelps's rivals go beyond American ...
Peek at the Week Norridge Harwood Heights News, IL - 6 minutes ago Resurrection Medical Center sponsors a variety of free cancer support groups for both patients and their family members. All support groups are free and ...
Tire Gauge Tim earns his own web page MinnPost.com, MN - Aug 5, 2008 Outrageous: As the Lake Phalen-area community was marching to support a cancer sufferer whose arm was broken with a baseball bat, two more people were ...
AHRA 2008 Post-Show Wrap-Up DOTmed.com (press release), NY - This procedure is less painful and decreases the likelihood of cancer reoccurrence. However, not as many women use this procedure because there is not ...
Source: Google News
Web-Based Survey of Fertility Issues in Young Women With Breast Cancer - AH Partridge, S Gelber, J Peppercorn, E Sampson, K … - Journal of Clinical Oncology, 2004 - jcojournal.org ... A, Gelber S, Knudsen K, et al: A Web-based survey ... Breast Cancer Res Treat 82:
S15-16, 2003 (suppl 1 ... Fertil Steril 55: 100-108, 1991[Medline]; Dunn J, Steginga ...
From the Cover: Prospective identification of tumorigenic breast cancer cells - M Al-Hajj, MS Wicha, A Benito-Hernandez, SJ … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences ... Related Commentary in PNAS: Breast cancer stem cells revealed John E. Dick
PNAS 2003 100: 3547-3549. [Extract] [Full Text]. This ...
Breast cancer classification and prognosis based on gene expression profiles from a population-based … - C Sotiriou, SY Neo, LM McShane, EL Korn, PM Long, … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences ... Additional analysis revealed that 100% of the specimens in ... as supporting information
on the PNAS web site ... associated with prognosis in breast cancer, only PCNA ...
Breast cancer stem cells revealed - JE Dick - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences ... of tumorigenic breast cancer cells Muhammad Al-Hajj, Max S. Wicha, Adalberto
Benito-Hernandez, Sean J. Morrison, and Michael F. Clarke PNAS 2003 100: 3983-3988 ...
Identification of gastric cancer patients by serum protein profiling - MP Ebert, J Meuer, JC Wiemer, HU Schulz, MA … - J Proteome Res, 2004 - pubs3.acs.org ... 10.1021/pr049865s S1535-3893(04)09865-3 Web Release Date: October 20 ... all 11 control
sera obtained from patients without gastric cancer (100% specificity) were ...
Gene expression profiles of human breast cancer progression - XJ Ma, R Salunga, JT Tuggle, J Gaudet, E Enright, … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences ... 13, 2003 | vol. 100 | no. 10 | 5974-5979 ... Genetics Gene expression profiles
of human breast cancer progression. Xiao-Jun Ma * , Ranelle ...
Detection of cancer-specific markers amid massive mass spectral data - W Zhu, X Wang, Y Ma, M Rao, J Glimm, JS Kovach - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences ... Food and Drug Administration Clinical Proteomics Program Databank web site (http ...
4-3-02 consisted of spectra from 100 patients with ovarian cancer and 116 ...
Source: Google Scholar
Cancer: SRC3, a powerful promoter of tumor growth
A new cellular pathway leads to destruction of a protein that promotes growth of breast, prostate and similar cancers and could provide a new avenue through which to pursue treatment of such diseases.
Bert O'Malley, at the Baylor College of Medicine, and his colleagues concentrated their efforts on a powerful oncogene or cancer-promoting gene called the steroid receptor coactivator ( SRC ) 3 which is also a powerful promoter of tumor growth.
" In high concentrations, it drives the cells to relentless replications," O'Malley said.
However, studies in the laboratory showed that another molecule called REG-GAMMA takes SRC3 to the proteasome where it is destroyed.
" Because REG-GAMMA does this to SRC3, it is a tumor suppressor," said O'Malley.
In breast cancer, when levels of REG-GAMMA are low, SRC3 levels can be high, resulting in tumor growth, said O'Malley.
" This is an important pathway for SRC3 degradation that has never been described," said O'Malley. Other modes of taking proteins to the proteasome for destruction involve adding a molecule called ubiquitin and using energy.
" This molecule does not require ubiquitin or an energy source," he said. " It's a really strange and different molecule for that reason."
