Funds raised to help ?Little Joe? Wapakoneta Daily News, OH - Joe Fargo, 8, was recently diagnosed with acute lymphoblastic leukemia.The son of Danielle and Joseph Fargo, of St. Marys, was diagnosed with ALL, ...
An easy way to help leukemia sufferers The Cornellian, IA - In this family, a 5-year old girl, Rian, was diagnosed with acute leukemia last year when she was only four years old. She currently has no match for bone ...
Styx River boy battles cancer Gulf Coast Newspapers, AL - Nov 30, 2008 Dalton had ALL or acute lymphoblastic leukemia. Also called acute lymphocytic leukemia, it is one of the most common kinds of leukemia found in children. ...
Our love story will live for ever GazetteLive, UK - Out of the blue, just two weeks before his 15th birthday, Graham was diagnosed with acute lymphoblastic leukaemia. In Newcastle?s Royal Victoria Infirmary, ...
How Childhood Leukemia Fights Back Science Now, DC - Nov 28, 2008 St. Jude Children's Research Hospital in Memphis holds one of the country's best tissue libraries of acute lymphoblastic leukemia (ALL), the most common ...
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Recent News and Articles on the Keywords: all + leukemia + lymphoblastic Related to the article below (Last Update: 8/7/2008)
Boy with leukemia raises funds for hospital Detroit Free Press, United States - Aug 6, 2008 Acute lymphoblastic leukemia is a cancer of the white blood cells, the cells that normally fight infection. After being diagnosed, Christoph noticed the ...
Enzon Reports Solid Second Quarter 2008 Results Business Wire (press release), CA - Oncaspar continues to be adopted in cooperative protocols for the first-line treatment of patients with acute lymphoblastic leukemia for both pediatric and ...ENZN
Author : The Leukemia & Lymphoma Society Earthtimes (press release), UK - Aug 4, 2008 Dr. Kelliher's research is focused on T-cell acute lymphoblastic leukemia (T-ALL), a form of blood cancer that still has a very poor prognosis. ...
Aztec Down Syndrome Girl Fights Leukemia RedOrbit, TX - Aug 3, 2008 Jessica has Acute Lymphoblastic Leukemia, the most common cancer in children, according to National Cancer Institute data. It represents 23 percent of ...
5K Race Brings In Record Number Of Runners WTOV9.com, OH - Aug 3, 2008 All proceeds from this years event will go to Anna Byers of Weirton, W.Va. Anna was diagnosed with acute lymphoblastic leukemia, but has since undergone two ...
Measurement of Residual Leukemia during Remission in Childhood Acute Lymphoblastic Leukemia - WM Roberts, Z Estrov, MV Ouspenskaia, DA Johnston, … - New England Journal of Medicine, 1997 - content.nejm.org ... Background Complete remission of B-precursor acute lymphoblasticleukemia (ALL)
has traditionally been defined as the near absence of lymphoblasts in a light ...
Residential Exposure to Magnetic Fields and Acute Lymphoblastic Leukemia in Children - MS Linet, EE Hatch, RA Kleinerman, LL Robison, WT … - New England Journal of Medicine, 1997 - content.nejm.org ... Methods We enrolled 638 children with acute lymphoblasticleukemia (ALL) who were
under 15 years of age and were registered with the Children's Cancer Group ...
Some infants with a type of leukaemia called acute lymphoblastic leukaemia (ALL) respond poorly to therapy. Now researchers have found that these patients actually have a type of leukaemia that is distinct from ALL, paving the way, they say, for targeted treatments.
ALL is a cancer of cells that develop into white blood cells. It is more common among children than adults and accounts for more than half of all childhood leukaemia`s.
Researchers already knew that many ALL patients who respond poorly to treatment have a defect in the "mixed lineage`` gene, which is located on chromosome 11.
Now with the help of gene chip technology, Dr. Scott A. Armstrong of the Dana-Farber Cancer Institute in Boston, Massachusetts, and colleagues have identified more than 1,000 genes that are expressed differently between ALL patients and patients with the mixed-lineage defect, suggesting it should be considered a distinct type of leukaemia.
Reporting in the advance online edition of Nature Genetics for December, Armstrong`s team suggests that these patients should be classified as having "mixed-lineage leukaemia`` (MLL) rather than ALL.
To determine whether MLL was a distinct form of leukemia, the researchers compared the expression of over 30,000 genes in 10 ALL samples and 17 MLL samples.
The investigators also compared genes expressed in ALL and MLL with those in another type of blood cancer called acute myelogenous leukaemia (AML); MLL cells have features similar to both ALL and AML cells. But they concluded that the diseases were "three distinct entities.``
"We expected to find that a few genes would be different between MLL and ALL, but the number we found immediately suggested to us that we were dealing with a different type of leukaemia,`` Armstrong says.
"This is exciting,`` Armstrong continued. "It`s not your standard ALL, and this is probably why these leukaemia`s don`t respond well to ALL therapy.``
According to Armstrong, a physician cannot tell an MLL patient from an ALL patient without sophisticated genetic tests, since the symptoms are the same, but "now that we know that MLL is distinct, we can start directing treatment with that in mind.``
He added, "It won`t immediately change the way we do things, but our ultimate goal is to develop new therapies based on the genes expressed in different types of leukaemia--ones that are less toxic and more specific.``
