Researchers say they have identified a protein they believe is key to the iron disorder

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Have We Found an ?Achilles? Heel of Life? That Causes Aging?
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The Growing Planetary Threat from Biological Weapons and Terrorism
Worldmeets.us, NY -
Such weapons have the following advantages. [Editor's Note: Botulinum toxin is a neurotoxic protein produced by the bacterium Clostridium botulinum. ...

A little protein goes a long way to keep your muscles going strong
WalesOnline, United Kingdom -
This means lifting weights ? they don?t have to be heavy ? or simply using your own body?s resistance with sit-ups for example or leg raises (see panel). ...

Christian Science Monitor

Europe hopes havens will give bees a break
Christian Science Monitor, MA - 10 minutes ago
In addition, the resolution from Strasbourg promotes the idea of "compensation zones," which would be cultivated with protein-rich flowers. ...

What makes us feel cold?
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A follow-up study attempted to locate the nerves in the body that produce the protein ? including whether they?re to blame for the tooth pain that some ...

CTV.ca

FDA finds traces of melamine in US infant formula
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CBC.ca

How to shop for your family without breaking the bank
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The results have been largely positive. "The kids are healthier and perkier and less sluggish," Evans says. "They're throwing out less food, there's less ...

Lessen the stress: Striking a holiday balance
Denver Post, CO -
"If you really love eggnog, have half a cup." Have a protein shake to coat your stomach before going to a cocktail party, and make your first "drink" a ...

Prostate Cancer Spurs New Nerves
Science Daily (press release) -
He and his colleagues have even identified a possible method of regulating the growth of new nerves and axons through a protein called semaphorin 4F. ...

Hole-y cow
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"So not only will they not have to buy an expensive feed at the co-op, they will just have to buy a protein supplement. If they can instead use the forage ...

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Maxygen Reports Second Quarter 2008 Financial Results
MarketWatch - Jul 31, 2008
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Northstar Neuroscience, Inc. Announces Revisions to its Strategic ...
Genetic Engineering News (press release), NY - Jul 31, 2008
Northstar Neuroscience is a medical device company focused on developing neuromodulation therapies to treat neurological injury, disorder, and disease. ...

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… Method on the Discrepancy between Judgments of Health Disorders People have and do not have: A Web … -
J Baron, DA Asch, A Fagerlin, C Jepson, G … - Medical Decision Making, 2003 - mdm.sagepub.com
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Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook
C Patrono - New England Journal of Medicine, 2008 - content.nejm.org
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Stroop Facilitation in Tinnitus Patients: An Experiment Conducted via the World Wide Web
PD GERHARD ANDERSSON, R BAKHSH, L JOHANSSON, V … - liebertonline.com
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… vivo urea cycle flux distinguishes and correlates with phenotypic severity in disorders of the urea … -
B Lee, H Yu, F Jahoor, WO'Brien, AL Beaudet, P … - Proceedings of the National Academy of Sciences, 2000 - National Acad Sciences
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Differential Hippocampal Expression of Glutamic Acid Decarboxylase 65 and 67 Messenger RNA in … -
S Heckers, D Stone, J Walsh, J Shick, P Koul, FM … - Archives of General Psychiatry, 2002 - Am Med Assoc
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Researchers say they have identified a protein they believe is key to the iron disorder hemochromatosis.

The finding could lead to new treatments for this relatively common disease, in which tissues become overloaded with iron. About one in every 200 to 300 Americans are affected by hemochromatosis, which can lead to organ failure if left untreated.

Reporting in the March issue of Cell Metabolism, researchers at Children’s Hospital Boston and Harvard Medical School study found the protein ferroportin is the major, and possibly only, iron exporter functioning at key points of iron absorption and release in the body. This suggests that iron accumulation in people with hemochromatosis may be the result of ferroportin-related loss of control over iron export.

"Iron is essential in the body and abundant in the environment, but it’s also very reactive and damaging when in excess. Mammals have therefore evolved mechanisms to get enough iron from the diet, but not too much," senior author Nancy Andrews said in a prepared statement.

She and her colleagues disabled ferroportin in select tissues and then systemwide in developing mice.

Mice that completely lacked ferroportin died early in development, due to a failure of iron transfer from mother to embryo. Mice lacking ferroportin in all tissues except those critical for nutrient transfer from the mother survived, but quickly become anemic after birth due to a lack of iron in the blood.

When the researchers examined the intestines, livers and spleens of these mice, they found an accumulation of iron within cells. This indicates that the cells aren’t able to release iron once it’s absorbed.

Mice that lacked ferroportin in their intestinal cells developed severe iron deficiency anemia. This further confirmed the role of ferroportin in iron absorption, the authors said.

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Recent News and Articles on the Keywords: they + protein + have Related to the article below (Last Update: 12/1/2008)

Recent News and Articles on the Keywords: disorders + 0.37 + web Related to the article below (Last Update: 8/7/2008)

Researchers say they have identified a protein they believe is key to the iron disorder hemochromatosis.