Treat HIV like other diseases Straits Times, Singapore - But some HIV medicines have been around for more than two decades and these drugs can no longer be classified as experimental. ...
Absent Vaccine, a New AIDS Debate Wall Street Journal Blogs, NY - Nov 26, 2008 Most HIV-positive South Africans are unaware of their status, and fewer than half of those who should be getting drug treatment under current guidelines are ...
Research traditional remedies The Times, South Africa - Nov 29, 2008 Cancer patients are also subject to side effects of chemotherapy while the drug works at killing the cancer. However, the vast majority of emaciated HIV...
Other News To Note TMCnet - Nov 26, 2008 Compugen also said CGEN-855 and supporting experimental data are the subject of an article published in the Journal of Pharmacology and Experimental...
Q&A with Larry Kramer Gay Wired, CA - Nov 27, 2008 HIV treatment is very good today. Did the emergence of better drugs play a roll in the fall-off of activism? Yes, we were working for treatments, ...
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FDA OKs Flu Vaccines for 2008-09 Season Washington Post, United States - 58 minutes ago The US Food and Drug Administration said it changed all three strains for this year's vaccine, which officials called an "unusual occurrence. ...
Meet AZ: The computer hacker behind a cybercrime wave USA Today - But cybercrime is now a fast-expanding, global industry, security researchers and law enforcement officials say. Because it most often goes undetected and ...
Attention Deficit Disorder Basil & Spice, FL - In sharp contrast, the US Food and Drug Administration?s web site states, as it has for more than a decade, that there is ?no evidence that food color ...
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Breast cancer: What you need to know Food Consumer, IL - Forsteronia refracta compound: Researchers at University of Virginia Health System isolated a compound from a rare South American plant called Forsteronia ...
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Researchers find promise in experimental drug for HIV/AIDS
Washington, Aug 10. (PTI): As global efforts to find a remedy for the dreaded HIV/AIDS disease gather more pace, US researchers are getting "excited" about an experimental drug, which is based on a herb and has been used successfully in Taiwan to treat diarrhoea and stem bleeding. The compound, bevirimat, is derived from a plant known by the Latin name Syzigium claviflorum, and if approved by the US Food and Drug Administration, would represent the first in a new class of drugs that use an unusual approach to block maturation of the AIDS virus, the Boston Globe reported. HIV borrows the human cell's replication machinery to make copies of itself and bevirimat interrupts the process at a key stage, resulting in harmless copies that the body quickly flushes.
However exciting the new finding may be, it is said that the new drug, developed by Panacos Pharamceuticals Inc., is about three years away from hitting the market.
Additionally it is being pointed out that the compound works later in the virus life cycle than protease inhibitors, which have been the mainstay of AIDS therapy so far.
Bevirimat is being developed as physicians begin to use drugs from different classes in combination to fight the virus at different steps in its life cycle.
"We can, once again, get control of virus replication in patients with the most advanced disease who are resistant to other drugs and really have a major impact on the course of disease and on survival in these patients," Daniel R. Kuritzkes, an associate professor of medicine at Harvard Medical School told the newspaper.
The opportunity now is to use bevirimat in potent combination with existing drugs, Kuritzkes, a paid consultant to Panacos, said.
That excitement over the drug comes at a time when doctors and researchers, on the eve of an International AIDS Convention in Toronto, Canada, are genuinely concerned about the unique ability of the HIV virus to fight off new drugs or in designing new "survival strategies".
More than 20 drugs are available to suppress the virus and at least 82 additional HIV therapies in development.
But as quickly as drug companies find ways to sabotage HIV, the virus develops new survival mechanism, says the report.
"We desperately need new compounds with novel mechanisms of action," said Eric Freed who is working with the HIV Drug Resistance Programme of the National Cancer Institute.
But it is being said that therapies have been improving over time.
By the calculations of researchers at Massachusetts General Hospital and Harvard Medical School, people who started AIDS therapy in 2003 lived an estimated 13 years longer than people diagnosed with AIDS in 1988, the report says.
"There aren't many new mechanism drugs," Graham P. Allaway, Panacos president, said in an interview to the paper. "So far, it looks potent, and it has a great safety profile."
"The proof of the pudding is always what happens when you give it to people and look at what the potency of the antiviral effect is," said Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases.
