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Reduction of blood pressure with oral magnesium supplementation in women with mild to moderate hypertension
JC Witteman, DE Grobbee, FH Derkx, R Bouillon, AM de Bruijn and A Hofman
Department of Epidemiology, Erasmus University Medical School, Rotterdam, The Netherlands.
In a double-blind controlled trial, 91 middle-aged and elderly women withmild to moderate hypertension who were not on antihypertensive medicationwere randomly assigned to treatment with magnesium aspartate- HCl (20 mmolMg/d) or placebo for 6 mo. Magnesium aspartate-HCl in the given dose waswell-tolerated and was not associated with an increased frequency ofdiarrhea compared with placebo. At the end of the study, systolic bloodpressure had fallen by 2.7 mm Hg (95% CI -1.2, 6.7; P = 0.18) and diastolicblood pressure by 3.4 mm Hg (1.3, 5.6; P = 0.003) more in the magnesiumgroup than in the placebo group. Blood pressure response was not associatedwith baseline magnesium status, as measured by dietary magnesium intake andurinary magnesium excretion. Urinary magnesium excretion in the magnesiumgroup increased by 50% during the intervention period. No changes were seenin other biochemical indexes, including serum concentrations of total andhigh-density-lipoprotein cholesterol. The findings suggest that oralsupplementation with magnesium aspartate-HCl may lower blood pressure insubjects with mild to moderate hypertension.
