Gene Test Could Predict Colon Cancer's Return U.S. News & World Report, DC - Nov 25, 2008 25 (HealthDay News) -- US researchers say they've developed a genetic model for predicting the risk of recurrence in patients with early stage colon cancer. ...
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Hadassah focuses on inherited cancer risk St.Louis Jewishlight.com, MO - Nov 29, 2008 Ivanovich outlined the steps in determining if a family has a genetic cancer risk. The first step is to look at family history of cancer, and make a chart ...
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Cancer survivor gives thanks Detroit Free Press, United States - Nov 27, 2008 Colorectal cancer, also called colon cancer, is the fourth most common cancer in men and women. When caught early, it is often curable, according to the ...
Cancer service offers free genetic screening SmallTownPapers News Service, WA - Nov 26, 2008 "The cancers for which we have some genetic testing to see if there are inherited risks are breast and ovarian cancer and colon cancer," Crow said. ...
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Alexion Reports Second Quarter 2008 Results PR Newswire (press release), NY - Jul 29, 2008 In addition, Alexion is pursuing development of an anti-CD200 monoclonal antibody as a treatment for patients with cancer, and evaluating development of ...ALXN
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Use and Benefits of a Web Site for Pancreatic Cancer - M Goggins, A Lietman, RE Miller, CJ Yeo, E Jaffee, … - JAMA, 1998 - Am Med Assoc ... 33%); and ?Mastectomy: A Treatment for Breast Cancer? (30 ... bulk of information on
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birth cohort (P = 0.27). The increase in breast cancer risk over time among ...
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0.45; stroke, 0.24; all cancers, 0.20; lung cancer, 0.27; breast cancer...
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[PDF]A gene expression database for the molecular pharmacology of cancer - U Scherf, DT Ross, M Waltham, LH Smith, JK Lee, L … - Nat Genet, 2000 - embnet.cl ... laboratories, as compiled at the DTP web site (http ... a pleural effusion of a patient
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Gene Defect Could Cause Colon Cancer
September 21, 2005 08:41:05 PM PST
Inactivation of a specific gene may be the underlying molecular defect driving the development of some colorectal cancers, researchers report.
The gene, called 06-methylguanine-DNA methyltransferase (MGMT), is involved in the repair of DNA. Detection of changes in MGMT could prove useful in measuring a person's risk for colorectal cancer, said the team from the University of Texas M.D. Anderson Cancer Center in Houston.
The researchers report their findings in the Sept. 21 issue of the Journal of the National Cancer Institute.
Cancer can begin in region of cells with what's called a "field defect." These cells appear normal but have an underlying molecular defect. In colorectal cancer cells, MGMT is often methylated -- meaning the gene's promoter region has methyl chemical groups added to it, resulting in an unhealthy inactivation of the gene.
In this study, researchers analyzed samples from 95 colorectal cancer patients and 33 people without cancer. MGMT promoter methylation was found in 50 percent to 94 percent of colorectal tumors.
"Given the high lifetime risk of colorectal tumor development in the U.S. population, it is reasonable to propose testing, to determine whether healthy persons with MGMT promoter methylation in normal colorectal [lining] are at higher risk of developing a colon tumor than those without such methylation," the researchers wrote.
