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Drug Companies Collaborate To Make All-In-One Cholesterol Pill
July 6, 2006 1:00 p.m. EST
Patricia Shehan - All Headline News Staff Writer
Abbott Park, IL (AHN) - Abbott Laboratories (a United States [U.S.] pharmaceutical company) and AstraZeneca (a British drug giant competitor) announced Wednesday their collaboration plans to create and market an all-in-one pill that will have a combined positive effect on all three blood lipids (i.e., LDLs, HDLs and triglycerides). The new pill will not only lower the LDLs (or "bad" cholesterol), but it will raise the HDLs (or "good" cholesterol), while also reducing triglycerides (fats that form in the bloodstream).
Abbott currently sells the cholesterol treatment, Tricor, and AstraZeneca currently sells the cholesterol-lowering drug, Crestor. The joint venture to develop the combination drug treatment will aid in lowering the risk of cardiovascular disease, which is known as the number one killer of both men and women.
The two companies plan to share in the costs and profits of the development of the combined drug during the collaboration agreement period. Plans for clinical trials are already underway. It is hoped that successful completion of the clinical trials will result in an approved drug format by the year 2009.
Tony Zook, the executive vice-president, North America, AstraZeneca, stated, "This represents an important further step in broadening the full, long-term potential of Crestor for the treatment of lipid disorders."
According to the Sun-Sentinel, as patents on well-known, top-selling prescription drugs begin to expire, competition could affect the $32 billion worldwide cholesterol market industry ($17 billion in the U.S.). Therefore, the new joint collaboration of the combination of these two companies will help protect each company's share of the extremely profitable pharmaceutical industry.
Eugene Sun, M.D., Vice-President of Global Pharmaceutical Clinical Development, Abbott Laboratories, says "Treatment guidelines emphasize the need to manage three important lipids by lowering bad cholesterol and triglycerides and raising good cholesterol. Increasing evidence shows that addressing these three key lipid targets helps to protect patients from heart disease. This collaboration has the potential to provide physicians and patients with the first statin and fibrate combination in a single pill to comprehensively manage lipids."
Peter H. Jones, M.D., an associate professor of medicine at Baylor College of Medicine in Houston, TX, stated that "Rigorous clinical study of these two drugs in combination to document their safety and efficacy is important for patients and could produce an important new comprehensive lipid treatment tool for physicians."
According to the American Heart Association there are greater than 38 million Americans alone who have complex lipid disease, a major cause of heart disease, who could benefit from this new drug combination. Of course, global numbers are even greater.
Poor in England more likely than rich to die in 50s
Last Updated: 2006-07-07 11:06:09 -0400 (Reuters Health)
By Patricia Reaney
LONDON - The poorest in England are over 10 times more likely to die in their 50s than richer people despite receiving similar healthcare, researchers said.
Obesity and smoking, two of the leading causes of preventable death, are more common in lower economic groups but Professor Michael Marmot of University College London said psychological factors and social position can also have an effect on health.
"There is an intricate relationship between wealth and health," said Marmot, the principal investigator of the English Longitudinal Study on Aging (ELSA).
ELSA follows the health, wealth, relationships, retirement and other issues of 8,780 people born before 1952 who are interviewed every two years.
"For each age group the richer had a lower risk of dying," Marmot told a news conference.
Wealthier people were also less likely to suffer from 17 common chronic diseases including high blood pressure and diabetes. But the quality of healthcare did not vary by wealth, which suggests other factors are also important.
About twice as many people in the poorest as opposed to the richer group felt isolated often or some of the time. Living alone was also more common in people on the lower economic levels.
"Adult social position has a clear effect on health," said Marmot, adding that in older people social isolation kills.
But according to the study, 60 percent of 75-year-olds are young at heart and did not think of themselves as old.
Marmot said studies done in European countries and the United States revealed similar findings linking health and wealth.
He added that the redistribution of wealth is not the answer to the problem, adding that a better understanding of the causal relationship is needed.
"The challenge is not to abolish hierarchies. It is to understand better what links your position in the hierarchy to your health," he said.
When earlier results of the ELSA study were compared with similar research in the United States it showed that Americans are not as healthy as the English. Americans had more illness in all income and education levels for six serious medical conditions than their neighbors across the Atlantic.
