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Recent News and Articles on the Keywords: cystic + fibrosis + 0.26 Related to the article below (Last Update: 8/5/2008)
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Orthoses provide only temporary relief of heel pain
Last Updated: 2006-07-07 15:57:11 -0400 (Reuters Health)
NEW YORK (Reuters Health) - Foot orthoses -- whether customized or prefabricated -- provide only small, short-term improvements in function and pain for patients with heel spurs, also known as plantar fasciitis, according to findings published in the Archives of Internal Medicine.
"Plantar fasciitis is one of the most common foot complaints," Dr. Karl B. Landorf, of La Trobe University, Victoria, Australia, and colleagues write. "It is often treated with foot orthoses; however, studies of the effects of orthoses are generally of poor quality, and to our knowledge, no trials have investigated long-term effectiveness."
The researchers therefore examined the short- and long-term effectiveness of foot orthoses in the treatment of plantar fasciitis in 135 patients with plantar fasciitis. The subjects were randomly assigned to receive a sham - a soft, thin piece of foam that looked like an orthosis; a prefabricated orthosis (firm foam); or a customized orthosis (semi-rigid plastic). None of the patients were told which type they were given. The researchers measured the patients' level of heel pain and function after 3 and 12 months.
Patients in the prefabricated and customized orthoses groups had improvements in pain and function after 3 months of treatment, but only the effect on function was statistically significant.
The average pain score (on a 0-100 scale) was 8.7 points better for the prefabricated orthosis group and 7.4 points better for the customized orthosis group compared to the sham orthosis group. The average function score was 8.4 and 7.5 points better in the prefabricated and customized orthoses groups, respectively, compared with the sham orthosis group.
However, no significant effects on pain or function were seen after 12 months in any of the groups.
Some doctors and plantar fasciitis patients may consider these results to be enough to justify the use of orthoses, Landorf and colleagues comment. "In that case, it is necessary to decide whether to use prefabricated or customized orthoses." They point out that there's little difference between the two, except that customized orthoses typically cost considerably more.
SOURCE: Archives of Internal Medicine, June 26, 2006.
U.S. researchers say they've identified and controlled an overactive protein that may be a key player in cystic fibrosis (CF).
CF is a genetic disorder that interferes with the body's ability to transport chloride in and out of cells.
According to researchers at Johns Hopkins Children's Center, Baltimore, the newly identified protein, called VCP/pr97, kills a chloride transporter in the cells of most CF patients. This inability to transport chloride results in a dangerous buildup of thick, sticky mucous in several organs, including the pancreas and lungs. That can lead to the malnutrition, chronic lung infection and lung damage so often seen in CF patients.
In this test-tube study, the researchers used a tool called RNA interference to successfully intercept signals sent out by VCP/pr97. In doing so, they were able to prevent cell damage caused by the protein. The findings showed promise in restoring cells to normal status in CF patients, the team said.
"The hope is that these findings will be used to design therapies and drugs that go beyond symptoms management and actually restore normal cell function to prevent CF," senior investigator Dr. Pamela Zeitlin, a pulmonologist at Johns Hopkins Children's Center, said in a prepared statement.
However, it will take years before any treatments based on this research are developed or tested on animals or humans, she noted.
The study was published in the June 23 issue of the Journal of Biological Chemistry.
